Diabetic retinopathy (DR) is a leading cause of blindness in people of working age in developed countries. DR is characterized by lesions of the retinal microvasculature. This paper describes a technique for visualizing the changes which occur in retinal pathology over a 1 year interval. Pairs of retinal images of the same eye were acuired 12 months apart within a DR screening programme. The images were normalized, registered and subtracted to generate a contrast-enhanced difference image displaying changes in retinal appearance. The normalization factor and registration error were quantified for 104 pairs of retinal images. (c) 2006 Elsevier Ltd. All rights reserved.
McRitchie, I. N., Hart, P. M., & Winder, J. (2006). Image registration and subtraction for the visualization of change in diabetic retinopathy screening. Computerized Medical Imaging and Graphics, 30(3), 139-145. https://doi.org/10.1016/j.compmedimag.2006.01.002