Identification of lesion components that influence visual function in age related macular degeneration

R Hogg, E Curry, A Muldrew, John Winder, M Stevenson, Moyra McClure, U Chakravarthy

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Aims: To explore the relation between lesion composition as assessed by fundus photography and fluorescein angiography with clinical measures of vision in eyes of patients with age related macular degeneration (AMD). Methods: A standardised visual function assessment along with colour stereo pair fundus photography was carried out in both eyes of 58 subjects with a confirmed clinical diagnosis of AMD. The size, location, and composition of the macular lesion (blood, exudate, subretinal fluid, pigment, membrane, atrophy, and fibrosis) were measured on the colour photographs using computer assisted image analysis. Of the 58 subjects, 44 also had concurrent fluorescein angiography. Classic and occult choroidal neovascularisation (CNV), blood, blocked fluorescence, fibrosis, geographic atrophy, and the total area of abnormal fluorescence were measured. Multiple linear regression was used to examine the relation between clinical measures of vision and the location and extent of lesion components identified by both colour and fluorescein image capture. Results: The composition of the macular lesion strongly influenced visual function, with atrophy (p=0.001) and fibrosis (p=0.002) accounting for most of the variation. When the location of the lesion with respect to the fovea was examined, fibrosis within the fovea significantly influenced all clinical measures of vision (p=0.008). The regression model selected the total area of abnormal fluorescence and a composite parameter (a semiquantitative measure of the following characteristics: atrophy, exudates, blood, and fibrosis) from colour photography (r(2)=0.52) as the variables that explained most of the variation in clinical measures of vision. Conclusions: The composition and extent of the macular lesion strongly influences visual function in eyes with AMD. Both colour photography and angiography yielded information, which together explained considerably more of the variation in the clinical measures of vision than either on its own.
LanguageEnglish
Pages609-614
JournalBRITISH JOURNAL OF OPHTHALMOLOGY
Volume87
Issue number5
Publication statusPublished - May 2003

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Macular Degeneration
Photography
Fibrosis
Color
Atrophy
Fluorescein Angiography
Fluorescence
Exudates and Transudates
Geographic Atrophy
Subretinal Fluid
Choroidal Neovascularization
Computer-Assisted Image Processing
Fluorescein
Linear Models
Angiography
Membranes

Cite this

Hogg, R., Curry, E., Muldrew, A., Winder, J., Stevenson, M., McClure, M., & Chakravarthy, U. (2003). Identification of lesion components that influence visual function in age related macular degeneration. BRITISH JOURNAL OF OPHTHALMOLOGY, 87(5), 609-614.
Hogg, R ; Curry, E ; Muldrew, A ; Winder, John ; Stevenson, M ; McClure, Moyra ; Chakravarthy, U. / Identification of lesion components that influence visual function in age related macular degeneration. In: BRITISH JOURNAL OF OPHTHALMOLOGY. 2003 ; Vol. 87, No. 5. pp. 609-614.
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abstract = "Aims: To explore the relation between lesion composition as assessed by fundus photography and fluorescein angiography with clinical measures of vision in eyes of patients with age related macular degeneration (AMD). Methods: A standardised visual function assessment along with colour stereo pair fundus photography was carried out in both eyes of 58 subjects with a confirmed clinical diagnosis of AMD. The size, location, and composition of the macular lesion (blood, exudate, subretinal fluid, pigment, membrane, atrophy, and fibrosis) were measured on the colour photographs using computer assisted image analysis. Of the 58 subjects, 44 also had concurrent fluorescein angiography. Classic and occult choroidal neovascularisation (CNV), blood, blocked fluorescence, fibrosis, geographic atrophy, and the total area of abnormal fluorescence were measured. Multiple linear regression was used to examine the relation between clinical measures of vision and the location and extent of lesion components identified by both colour and fluorescein image capture. Results: The composition of the macular lesion strongly influenced visual function, with atrophy (p=0.001) and fibrosis (p=0.002) accounting for most of the variation. When the location of the lesion with respect to the fovea was examined, fibrosis within the fovea significantly influenced all clinical measures of vision (p=0.008). The regression model selected the total area of abnormal fluorescence and a composite parameter (a semiquantitative measure of the following characteristics: atrophy, exudates, blood, and fibrosis) from colour photography (r(2)=0.52) as the variables that explained most of the variation in clinical measures of vision. Conclusions: The composition and extent of the macular lesion strongly influences visual function in eyes with AMD. Both colour photography and angiography yielded information, which together explained considerably more of the variation in the clinical measures of vision than either on its own.",
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Hogg, R, Curry, E, Muldrew, A, Winder, J, Stevenson, M, McClure, M & Chakravarthy, U 2003, 'Identification of lesion components that influence visual function in age related macular degeneration', BRITISH JOURNAL OF OPHTHALMOLOGY, vol. 87, no. 5, pp. 609-614.

Identification of lesion components that influence visual function in age related macular degeneration. / Hogg, R; Curry, E; Muldrew, A; Winder, John; Stevenson, M; McClure, Moyra; Chakravarthy, U.

In: BRITISH JOURNAL OF OPHTHALMOLOGY, Vol. 87, No. 5, 05.2003, p. 609-614.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Identification of lesion components that influence visual function in age related macular degeneration

AU - Hogg, R

AU - Curry, E

AU - Muldrew, A

AU - Winder, John

AU - Stevenson, M

AU - McClure, Moyra

AU - Chakravarthy, U

PY - 2003/5

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N2 - Aims: To explore the relation between lesion composition as assessed by fundus photography and fluorescein angiography with clinical measures of vision in eyes of patients with age related macular degeneration (AMD). Methods: A standardised visual function assessment along with colour stereo pair fundus photography was carried out in both eyes of 58 subjects with a confirmed clinical diagnosis of AMD. The size, location, and composition of the macular lesion (blood, exudate, subretinal fluid, pigment, membrane, atrophy, and fibrosis) were measured on the colour photographs using computer assisted image analysis. Of the 58 subjects, 44 also had concurrent fluorescein angiography. Classic and occult choroidal neovascularisation (CNV), blood, blocked fluorescence, fibrosis, geographic atrophy, and the total area of abnormal fluorescence were measured. Multiple linear regression was used to examine the relation between clinical measures of vision and the location and extent of lesion components identified by both colour and fluorescein image capture. Results: The composition of the macular lesion strongly influenced visual function, with atrophy (p=0.001) and fibrosis (p=0.002) accounting for most of the variation. When the location of the lesion with respect to the fovea was examined, fibrosis within the fovea significantly influenced all clinical measures of vision (p=0.008). The regression model selected the total area of abnormal fluorescence and a composite parameter (a semiquantitative measure of the following characteristics: atrophy, exudates, blood, and fibrosis) from colour photography (r(2)=0.52) as the variables that explained most of the variation in clinical measures of vision. Conclusions: The composition and extent of the macular lesion strongly influences visual function in eyes with AMD. Both colour photography and angiography yielded information, which together explained considerably more of the variation in the clinical measures of vision than either on its own.

AB - Aims: To explore the relation between lesion composition as assessed by fundus photography and fluorescein angiography with clinical measures of vision in eyes of patients with age related macular degeneration (AMD). Methods: A standardised visual function assessment along with colour stereo pair fundus photography was carried out in both eyes of 58 subjects with a confirmed clinical diagnosis of AMD. The size, location, and composition of the macular lesion (blood, exudate, subretinal fluid, pigment, membrane, atrophy, and fibrosis) were measured on the colour photographs using computer assisted image analysis. Of the 58 subjects, 44 also had concurrent fluorescein angiography. Classic and occult choroidal neovascularisation (CNV), blood, blocked fluorescence, fibrosis, geographic atrophy, and the total area of abnormal fluorescence were measured. Multiple linear regression was used to examine the relation between clinical measures of vision and the location and extent of lesion components identified by both colour and fluorescein image capture. Results: The composition of the macular lesion strongly influenced visual function, with atrophy (p=0.001) and fibrosis (p=0.002) accounting for most of the variation. When the location of the lesion with respect to the fovea was examined, fibrosis within the fovea significantly influenced all clinical measures of vision (p=0.008). The regression model selected the total area of abnormal fluorescence and a composite parameter (a semiquantitative measure of the following characteristics: atrophy, exudates, blood, and fibrosis) from colour photography (r(2)=0.52) as the variables that explained most of the variation in clinical measures of vision. Conclusions: The composition and extent of the macular lesion strongly influences visual function in eyes with AMD. Both colour photography and angiography yielded information, which together explained considerably more of the variation in the clinical measures of vision than either on its own.

M3 - Article

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EP - 614

JO - British Journal of Ophthalmology

T2 - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 5

ER -