Identification of central sites involved in butorphanol-induced feeding in rats

Eun-Mee Kim, Q Shi, PK Olszewski, MK Grace, E O'Hare, CJ Billington, AS Levine

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Butorphanol (BT), a mixed kappa- and mu -opioid receptor agonist, induces vigorous food intake in rats. Peripheral injection of BT seems to increase food intake more effectively than intracerebroventricular administration. To further elucidate the nature of BT's influence on consummatory behavior. we examined which feeding-related brain areas exhibit increased c-Fos immunoreactivity (IR) following subcutaneous injection of 4 mg/kg body weight BT, a dose known to induce a maximal orexigenic response. We also evaluated whether direct administration of BT into the forebrain regions activated by peripheral BT injection affects food intake. Peripheral BT administration induced c-Fos-IR in the hypothalamic paraventricular nucleus (PVN), central nucleus of the amygdala (CeA), and nucleus of the solitary tract (NTS). However, 0.1-30 mug BT infused into the CeA, failed mo increase food intake 1, 2, and 4 h after injection. Only the highest dose of BT (30 mug) injected into the PVN: increased feeding. These results suggest that the PVN, CeA, and NTS mediate the effects of peripherally-injected BT. The PVN or CeA are probably not the main target sites of immediate BT action. Published by Elsevier Science B.V.
LanguageEnglish
Pages125-129
JournalBrain Research
Volume907
Issue number1-2
Publication statusPublished - Jul 2001

Fingerprint

Butorphanol
Paraventricular Hypothalamic Nucleus
Eating
Injections
Consummatory Behavior
kappa Opioid Receptor
Solitary Nucleus
mu Opioid Receptor
Subcutaneous Injections
Prosencephalon
Body Weight

Cite this

Kim, E-M., Shi, Q., Olszewski, PK., Grace, MK., O'Hare, E., Billington, CJ., & Levine, AS. (2001). Identification of central sites involved in butorphanol-induced feeding in rats. Brain Research, 907(1-2), 125-129.
Kim, Eun-Mee ; Shi, Q ; Olszewski, PK ; Grace, MK ; O'Hare, E ; Billington, CJ ; Levine, AS. / Identification of central sites involved in butorphanol-induced feeding in rats. In: Brain Research. 2001 ; Vol. 907, No. 1-2. pp. 125-129.
@article{62e96882994945bd9667e28ba51b74d6,
title = "Identification of central sites involved in butorphanol-induced feeding in rats",
abstract = "Butorphanol (BT), a mixed kappa- and mu -opioid receptor agonist, induces vigorous food intake in rats. Peripheral injection of BT seems to increase food intake more effectively than intracerebroventricular administration. To further elucidate the nature of BT's influence on consummatory behavior. we examined which feeding-related brain areas exhibit increased c-Fos immunoreactivity (IR) following subcutaneous injection of 4 mg/kg body weight BT, a dose known to induce a maximal orexigenic response. We also evaluated whether direct administration of BT into the forebrain regions activated by peripheral BT injection affects food intake. Peripheral BT administration induced c-Fos-IR in the hypothalamic paraventricular nucleus (PVN), central nucleus of the amygdala (CeA), and nucleus of the solitary tract (NTS). However, 0.1-30 mug BT infused into the CeA, failed mo increase food intake 1, 2, and 4 h after injection. Only the highest dose of BT (30 mug) injected into the PVN: increased feeding. These results suggest that the PVN, CeA, and NTS mediate the effects of peripherally-injected BT. The PVN or CeA are probably not the main target sites of immediate BT action. Published by Elsevier Science B.V.",
author = "Eun-Mee Kim and Q Shi and PK Olszewski and MK Grace and E O'Hare and CJ Billington and AS Levine",
year = "2001",
month = "7",
language = "English",
volume = "907",
pages = "125--129",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

Kim, E-M, Shi, Q, Olszewski, PK, Grace, MK, O'Hare, E, Billington, CJ & Levine, AS 2001, 'Identification of central sites involved in butorphanol-induced feeding in rats', Brain Research, vol. 907, no. 1-2, pp. 125-129.

Identification of central sites involved in butorphanol-induced feeding in rats. / Kim, Eun-Mee; Shi, Q; Olszewski, PK; Grace, MK; O'Hare, E; Billington, CJ; Levine, AS.

In: Brain Research, Vol. 907, No. 1-2, 07.2001, p. 125-129.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Identification of central sites involved in butorphanol-induced feeding in rats

AU - Kim, Eun-Mee

AU - Shi, Q

AU - Olszewski, PK

AU - Grace, MK

AU - O'Hare, E

AU - Billington, CJ

AU - Levine, AS

PY - 2001/7

Y1 - 2001/7

N2 - Butorphanol (BT), a mixed kappa- and mu -opioid receptor agonist, induces vigorous food intake in rats. Peripheral injection of BT seems to increase food intake more effectively than intracerebroventricular administration. To further elucidate the nature of BT's influence on consummatory behavior. we examined which feeding-related brain areas exhibit increased c-Fos immunoreactivity (IR) following subcutaneous injection of 4 mg/kg body weight BT, a dose known to induce a maximal orexigenic response. We also evaluated whether direct administration of BT into the forebrain regions activated by peripheral BT injection affects food intake. Peripheral BT administration induced c-Fos-IR in the hypothalamic paraventricular nucleus (PVN), central nucleus of the amygdala (CeA), and nucleus of the solitary tract (NTS). However, 0.1-30 mug BT infused into the CeA, failed mo increase food intake 1, 2, and 4 h after injection. Only the highest dose of BT (30 mug) injected into the PVN: increased feeding. These results suggest that the PVN, CeA, and NTS mediate the effects of peripherally-injected BT. The PVN or CeA are probably not the main target sites of immediate BT action. Published by Elsevier Science B.V.

AB - Butorphanol (BT), a mixed kappa- and mu -opioid receptor agonist, induces vigorous food intake in rats. Peripheral injection of BT seems to increase food intake more effectively than intracerebroventricular administration. To further elucidate the nature of BT's influence on consummatory behavior. we examined which feeding-related brain areas exhibit increased c-Fos immunoreactivity (IR) following subcutaneous injection of 4 mg/kg body weight BT, a dose known to induce a maximal orexigenic response. We also evaluated whether direct administration of BT into the forebrain regions activated by peripheral BT injection affects food intake. Peripheral BT administration induced c-Fos-IR in the hypothalamic paraventricular nucleus (PVN), central nucleus of the amygdala (CeA), and nucleus of the solitary tract (NTS). However, 0.1-30 mug BT infused into the CeA, failed mo increase food intake 1, 2, and 4 h after injection. Only the highest dose of BT (30 mug) injected into the PVN: increased feeding. These results suggest that the PVN, CeA, and NTS mediate the effects of peripherally-injected BT. The PVN or CeA are probably not the main target sites of immediate BT action. Published by Elsevier Science B.V.

M3 - Article

VL - 907

SP - 125

EP - 129

JO - Brain Research

T2 - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -

Kim E-M, Shi Q, Olszewski PK, Grace MK, O'Hare E, Billington CJ et al. Identification of central sites involved in butorphanol-induced feeding in rats. Brain Research. 2001 Jul;907(1-2):125-129.