Hypoxia-inducible factor (HIF): fuel for cancer progression

Saurabh Satija, Harpreet Kaur, Murtaza M. Tambuwala, Prabal Sharma, Manish Vyas, Navneet Khurana, Neha Sharma, Hamid A. Bakshi, Nitin B. Charbe, Flavia C Zacconi, Alaa A. Aljabali, Srinivas Nammi, Harish Dureja, Thakur Gurjeet Singh, Gaurav Gupta, Daljeet S. Dhanjal, Kamal Dua, Dinesh Kumar Chellappan, Meenu Mehta

Research output: Contribution to journalArticlepeer-review

Abstract

Hypoxia is an integral part of tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic pathways, HIF-1 transcription factor activation is one of the widely investigated pathways in the hypoxic tumor microenvironment (TME). HIF-1 is known to activate several adaptive reactions in response to oxygen deficiency in tumor cells. HIF-1 has two subunits, HIF-1β (constitutive) and HIF-1α (inducible). The HIF-1α expression is largely regulated via various cytokines (through PI3K-ACT-mTOR signals), which involves the cascading of several growth factors and oncogenic cascades. These events lead to the loss of cellular tumor suppressant activity through changes in the level of oxygen via oxygen-dependent and oxygen-independent pathways. The significant and crucial role of HIF in cancer progression and its underlying mechanisms have gained much attention lately among the translational researchers in the fields of cancer and biological sciences, which have enabled them to correlate these mechanisms with various other disease modalities. In the present review, we have summarized the key findings related to the role of HIF in the progression of tumors.
Original languageEnglish
JournalCurrent Molecular Pharmacology
Volume14
DOIs
Publication statusPublished - 26 Jan 2021

Keywords

  • HIF
  • Hypoxia
  • cancer progression
  • hydroxylation
  • microenvironment
  • normoxia
  • tumor

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