Hydrogels for peptide hormones delivery: Therapeutic and tissue engineering applications

Mohsen Doostmohammadi; Atefeh Ameri; Reza Mohammadinejad; Negar Dehghannoudeh; Ibrahim M. Banat; Mandana Ohadi; Gholamreza Dehghannoudeh

doi:10.2147/DDDT.S217211

Hydrogels for peptide hormones delivery: Therapeutic and tissue engineering applications

Mohsen Doostmohammadi, Atefeh Ameri, Reza Mohammadinejad, Negar Dehghannoudeh, Ibrahim M. Banat, Mandana Ohadi, Gholamreza Dehghannoudeh

School of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

46 Downloads (Pure)

Abstract

Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cells is ideal and would be effective for disease treatment. Until now, plenty of polymers, e.g., polysaccharides, polypeptides, and lipids were used in drug delivery. Hydrogels made from polysaccharides showed significant development in targeted delivery of peptide hormones because of their natural characteristics such as networks, pore sizes, sustainability, and response to external stimuli. The main aim of the present review was therefore, to gather the important usages of the hydrogels as a carrier in peptide hormone delivery and their application in tissue engineering and regenerative medicine.

Original language	English
Pages (from-to)	3405-3418
Number of pages	14
Journal	Drug Design, Development and Therapy
Volume	13
DOIs	https://doi.org/10.2147/DDDT.S217211
Publication status	Published (in print/issue) - 26 Sept 2019

Bibliographical note

Funding Information:
The authors would like to thank Kerman University of Medical Sciences (KMU) for facilitating relevant research into the conclusions related to this study.

Publisher Copyright:
© 2019 Doostmohammadi et al.

Keywords

Drug delivery
Hydrogels
Peptides hormones
Tissue engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2147/DDDT.S217211Licence: CC BY-NC

dddt-217211-hydrogels-for-peptide-hormones-delivery-therapeutic-and-tisFinal published version, 968 KBLicence: CC BY-NC

Cite this

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title = "Hydrogels for peptide hormones delivery: Therapeutic and tissue engineering applications",

abstract = "Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cells is ideal and would be effective for disease treatment. Until now, plenty of polymers, e.g., polysaccharides, polypeptides, and lipids were used in drug delivery. Hydrogels made from polysaccharides showed significant development in targeted delivery of peptide hormones because of their natural characteristics such as networks, pore sizes, sustainability, and response to external stimuli. The main aim of the present review was therefore, to gather the important usages of the hydrogels as a carrier in peptide hormone delivery and their application in tissue engineering and regenerative medicine.",

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AU - Doostmohammadi, Mohsen

AU - Ameri, Atefeh

AU - Mohammadinejad, Reza

AU - Dehghannoudeh, Negar

AU - Banat, Ibrahim M.

AU - Ohadi, Mandana

AU - Dehghannoudeh, Gholamreza

N1 - Funding Information: The authors would like to thank Kerman University of Medical Sciences (KMU) for facilitating relevant research into the conclusions related to this study. Publisher Copyright: © 2019 Doostmohammadi et al.

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N2 - Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cells is ideal and would be effective for disease treatment. Until now, plenty of polymers, e.g., polysaccharides, polypeptides, and lipids were used in drug delivery. Hydrogels made from polysaccharides showed significant development in targeted delivery of peptide hormones because of their natural characteristics such as networks, pore sizes, sustainability, and response to external stimuli. The main aim of the present review was therefore, to gather the important usages of the hydrogels as a carrier in peptide hormone delivery and their application in tissue engineering and regenerative medicine.

AB - Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cells is ideal and would be effective for disease treatment. Until now, plenty of polymers, e.g., polysaccharides, polypeptides, and lipids were used in drug delivery. Hydrogels made from polysaccharides showed significant development in targeted delivery of peptide hormones because of their natural characteristics such as networks, pore sizes, sustainability, and response to external stimuli. The main aim of the present review was therefore, to gather the important usages of the hydrogels as a carrier in peptide hormone delivery and their application in tissue engineering and regenerative medicine.

KW - Drug delivery

KW - Hydrogels

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KW - Tissue engineering

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M3 - Review article

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VL - 13

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JO - Drug Design, Development and Therapy

JF - Drug Design, Development and Therapy

ER -

Hydrogels for peptide hormones delivery: Therapeutic and tissue engineering applications

Abstract

Bibliographical note

Keywords

UN SDGs

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