Hydrogel as a Nerve Guide and Biocompatible Glue for Neural Applications

Srinivasu Puttaswamy, Aishwarya Bandla, Sam Fishlock, Sanghoon lee, Chengkuo Lee, James McLaughlin

Research output: Contribution to conferencePaper

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Abstract

In the present work, Poly(ethylene glycol) (PEG) biocompatible hydrogel has been employed for two neural applications: nerve guide conduits and as an in-vitro neural bioglue. Nerve guide conduits (NGCs) are widely accepted in
the treatment of peripheral nerve injuries. In the first application, we present the design of a simple and low-cost method to fabricate hydrogel-based NGCs. In this method we employ light curing method for 5 seconds to fabricate NGCs in a short span of time. The fabricated NGC was assessed in vitro to demonstrate the neural application. The efficient, low-cost and simple method proposed in this study addresses the limitations in existing expensive and time-consuming techniques of fabricating NGCs. Secondly, we demonstrate the application of PEGDA as an in-vitro neural bioglue. Micro electrode neural interface requires effective binding to achieve low signal-to-noise ratio during neural signal recording, hence there is a great demand for developing surgical glues which are nontoxic, biocompatible and which work well in highly corrosive environments within the body.
We employed a photosensitive hydrogel, which can be cured within a few seconds to secure electrodes when interfaced with small nerves.
Original languageEnglish
Publication statusPublished - 28 Jan 2018
EventIEEE International Conference on Nanotechnology - Cork, Ireland
Duration: 23 Jul 201826 Jul 2018

Conference

ConferenceIEEE International Conference on Nanotechnology
CountryIreland
CityCork
Period23/07/1826/07/18

Keywords

  • Nerve Guide
  • Biocompatible Glue
  • Hydrogel

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