Hydrogel as a Nerve Guide and Biocompatible Glue for Neural Applications

Srinivasu Puttaswamy, Aishwarya Bandla, Sam Fishlock, Sanghoon lee, Chengkuo Lee, James McLaughlin

Research output: Contribution to conferencePaper

Abstract

In the present work, Poly(ethylene glycol) (PEG) biocompatible hydrogel has been employed for two neural applications: nerve guide conduits and as an in-vitro neural bioglue. Nerve guide conduits (NGCs) are widely accepted in
the treatment of peripheral nerve injuries. In the first application, we present the design of a simple and low-cost method to fabricate hydrogel-based NGCs. In this method we employ light curing method for 5 seconds to fabricate NGCs in a short span of time. The fabricated NGC was assessed in vitro to demonstrate the neural application. The efficient, low-cost and simple method proposed in this study addresses the limitations in existing expensive and time-consuming techniques of fabricating NGCs. Secondly, we demonstrate the application of PEGDA as an in-vitro neural bioglue. Micro electrode neural interface requires effective binding to achieve low signal-to-noise ratio during neural signal recording, hence there is a great demand for developing surgical glues which are nontoxic, biocompatible and which work well in highly corrosive environments within the body.
We employed a photosensitive hydrogel, which can be cured within a few seconds to secure electrodes when interfaced with small nerves.

Conference

ConferenceIEEE International Conference on Nanotechnology
CountryIreland
CityCork
Period23/07/1826/07/18

Fingerprint

Hydrogel
Adhesives
Electrodes
Costs and Cost Analysis
Peripheral Nerve Injuries
Caustics
Ethylene Glycol
Signal-To-Noise Ratio
Light
In Vitro Techniques
Bio-glue

Keywords

  • Nerve Guide
  • Biocompatible Glue
  • Hydrogel

Cite this

Puttaswamy, S., Bandla, A., Fishlock, S., lee, S., Lee, C., & McLaughlin, J. (2018). Hydrogel as a Nerve Guide and Biocompatible Glue for Neural Applications. Paper presented at IEEE International Conference on Nanotechnology, Cork, Ireland.
Puttaswamy, Srinivasu ; Bandla, Aishwarya ; Fishlock, Sam ; lee, Sanghoon ; Lee, Chengkuo ; McLaughlin, James. / Hydrogel as a Nerve Guide and Biocompatible Glue for Neural Applications. Paper presented at IEEE International Conference on Nanotechnology, Cork, Ireland.
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abstract = "In the present work, Poly(ethylene glycol) (PEG) biocompatible hydrogel has been employed for two neural applications: nerve guide conduits and as an in-vitro neural bioglue. Nerve guide conduits (NGCs) are widely accepted in the treatment of peripheral nerve injuries. In the first application, we present the design of a simple and low-cost method to fabricate hydrogel-based NGCs. In this method we employ light curing method for 5 seconds to fabricate NGCs in a short span of time. The fabricated NGC was assessed in vitro to demonstrate the neural application. The efficient, low-cost and simple method proposed in this study addresses the limitations in existing expensive and time-consuming techniques of fabricating NGCs. Secondly, we demonstrate the application of PEGDA as an in-vitro neural bioglue. Micro electrode neural interface requires effective binding to achieve low signal-to-noise ratio during neural signal recording, hence there is a great demand for developing surgical glues which are nontoxic, biocompatible and which work well in highly corrosive environments within the body. We employed a photosensitive hydrogel, which can be cured within a few seconds to secure electrodes when interfaced with small nerves.",
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Puttaswamy, S, Bandla, A, Fishlock, S, lee, S, Lee, C & McLaughlin, J 2018, 'Hydrogel as a Nerve Guide and Biocompatible Glue for Neural Applications' Paper presented at IEEE International Conference on Nanotechnology, Cork, Ireland, 23/07/18 - 26/07/18, .

Hydrogel as a Nerve Guide and Biocompatible Glue for Neural Applications. / Puttaswamy, Srinivasu; Bandla, Aishwarya; Fishlock, Sam; lee, Sanghoon; Lee, Chengkuo; McLaughlin, James.

2018. Paper presented at IEEE International Conference on Nanotechnology, Cork, Ireland.

Research output: Contribution to conferencePaper

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T1 - Hydrogel as a Nerve Guide and Biocompatible Glue for Neural Applications

AU - Puttaswamy, Srinivasu

AU - Bandla, Aishwarya

AU - Fishlock, Sam

AU - lee, Sanghoon

AU - Lee, Chengkuo

AU - McLaughlin, James

N1 - IEEE NANO 2018

PY - 2018/1/28

Y1 - 2018/1/28

N2 - In the present work, Poly(ethylene glycol) (PEG) biocompatible hydrogel has been employed for two neural applications: nerve guide conduits and as an in-vitro neural bioglue. Nerve guide conduits (NGCs) are widely accepted in the treatment of peripheral nerve injuries. In the first application, we present the design of a simple and low-cost method to fabricate hydrogel-based NGCs. In this method we employ light curing method for 5 seconds to fabricate NGCs in a short span of time. The fabricated NGC was assessed in vitro to demonstrate the neural application. The efficient, low-cost and simple method proposed in this study addresses the limitations in existing expensive and time-consuming techniques of fabricating NGCs. Secondly, we demonstrate the application of PEGDA as an in-vitro neural bioglue. Micro electrode neural interface requires effective binding to achieve low signal-to-noise ratio during neural signal recording, hence there is a great demand for developing surgical glues which are nontoxic, biocompatible and which work well in highly corrosive environments within the body. We employed a photosensitive hydrogel, which can be cured within a few seconds to secure electrodes when interfaced with small nerves.

AB - In the present work, Poly(ethylene glycol) (PEG) biocompatible hydrogel has been employed for two neural applications: nerve guide conduits and as an in-vitro neural bioglue. Nerve guide conduits (NGCs) are widely accepted in the treatment of peripheral nerve injuries. In the first application, we present the design of a simple and low-cost method to fabricate hydrogel-based NGCs. In this method we employ light curing method for 5 seconds to fabricate NGCs in a short span of time. The fabricated NGC was assessed in vitro to demonstrate the neural application. The efficient, low-cost and simple method proposed in this study addresses the limitations in existing expensive and time-consuming techniques of fabricating NGCs. Secondly, we demonstrate the application of PEGDA as an in-vitro neural bioglue. Micro electrode neural interface requires effective binding to achieve low signal-to-noise ratio during neural signal recording, hence there is a great demand for developing surgical glues which are nontoxic, biocompatible and which work well in highly corrosive environments within the body. We employed a photosensitive hydrogel, which can be cured within a few seconds to secure electrodes when interfaced with small nerves.

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Puttaswamy S, Bandla A, Fishlock S, lee S, Lee C, McLaughlin J. Hydrogel as a Nerve Guide and Biocompatible Glue for Neural Applications. 2018. Paper presented at IEEE International Conference on Nanotechnology, Cork, Ireland.