How to build your own island

Colum Walsh; Avinash Thakur

doi:10.7554/eLife.04779

How to build your own island

Research output: Contribution to journal › Article › peer-review

Abstract

Navigating your way through the sea ofinformation that is contained in the DNAof a genome can be a daunting task. Thehuman genome, for example, contains about 3billion base pairs and encodes around 20,000genes. It is fortunate, therefore, that this sea ispunctuated by ‘islands’ that mark the locations ofimportant features. CpG islands, for example,mark the start of genes so reliably that they wereused to identify genes in the pre-genomics era,before sequence information was so readily available.Despite this, we still do not fully understandwhy such islands are associated with essential DNAfeatures, or which properties of these islands arecrucial to their function.

Original language	English
Journal	eLife
Volume	3
DOIs	https://doi.org/10.7554/eLife.04779
Publication status	Accepted/In press - 21 Oct 2014

Keywords

CpG islands
DNA methylation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.7554/eLife.04779

http://uir.ulster.ac.uk/34778/1/e04779-download.pdf

Cite this

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title = "How to build your own island",

abstract = "Navigating your way through the sea ofinformation that is contained in the DNAof a genome can be a daunting task. Thehuman genome, for example, contains about 3billion base pairs and encodes around 20,000genes. It is fortunate, therefore, that this sea ispunctuated by {\textquoteleft}islands{\textquoteright} that mark the locations ofimportant features. CpG islands, for example,mark the start of genes so reliably that they wereused to identify genes in the pre-genomics era,before sequence information was so readily available.Despite this, we still do not fully understandwhy such islands are associated with essential DNAfeatures, or which properties of these islands arecrucial to their function.",

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AB - Navigating your way through the sea ofinformation that is contained in the DNAof a genome can be a daunting task. Thehuman genome, for example, contains about 3billion base pairs and encodes around 20,000genes. It is fortunate, therefore, that this sea ispunctuated by ‘islands’ that mark the locations ofimportant features. CpG islands, for example,mark the start of genes so reliably that they wereused to identify genes in the pre-genomics era,before sequence information was so readily available.Despite this, we still do not fully understandwhy such islands are associated with essential DNAfeatures, or which properties of these islands arecrucial to their function.

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How to build your own island

Abstract

Keywords

UN SDGs

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