Hot melt extruded HPC based formulations to control drug release

Matthew Wilson, G. P. Andrews, DS Jones

Research output: Contribution to conferenceAbstract

Abstract

Over the last five years there has been a growing interest in the capabilities of Hot Melt Extrusion (HME) for the rapid production of solid oral dosage forms to provide sustained or controlled release (1). Many of the polymers used in production form hydrogels some of which respond to temperature. At the Low Critical Solution Temperature (LCST), there is an abrupt phase transition as the hydrophobic groups align and cause the gel to collapse and shrink(2). LCST materials can force out the drug as the gel shrinks.
This study details the application of HME formulations containing Hydroxypropylcellulose (HPC) as a base polymer using a combination of Methylcellulose (MC) and Hydroxypropylmethylcellulose (HPMC). The limit to which formulation controlled drug release under varying hydrodynamic effects, high alcohol environments and high and low drug loads were investigated using.

Conference

Conference35th All Ireland Schools Conference
CountryNorthern Ireland
CityBelfast
Period25/03/1326/03/13

Fingerprint

Extrusion
Polymers
Gels
Pharmaceutical Preparations
Hydrogels
Methylcellulose
Dosage Forms
Temperature
Hydrodynamics
Phase transitions
Alcohols
hydroxypropylcellulose
Hypromellose Derivatives

Cite this

Wilson, M., Andrews, G. P., & Jones, DS. (Accepted/In press). Hot melt extruded HPC based formulations to control drug release. Abstract from 35th All Ireland Schools Conference, Belfast, Northern Ireland.
Wilson, Matthew ; Andrews, G. P. ; Jones, DS. / Hot melt extruded HPC based formulations to control drug release. Abstract from 35th All Ireland Schools Conference, Belfast, Northern Ireland.
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title = "Hot melt extruded HPC based formulations to control drug release",
abstract = "Over the last five years there has been a growing interest in the capabilities of Hot Melt Extrusion (HME) for the rapid production of solid oral dosage forms to provide sustained or controlled release (1). Many of the polymers used in production form hydrogels some of which respond to temperature. At the Low Critical Solution Temperature (LCST), there is an abrupt phase transition as the hydrophobic groups align and cause the gel to collapse and shrink(2). LCST materials can force out the drug as the gel shrinks.This study details the application of HME formulations containing Hydroxypropylcellulose (HPC) as a base polymer using a combination of Methylcellulose (MC) and Hydroxypropylmethylcellulose (HPMC). The limit to which formulation controlled drug release under varying hydrodynamic effects, high alcohol environments and high and low drug loads were investigated using.",
author = "Matthew Wilson and Andrews, {G. P.} and DS Jones",
note = "Conference paper and poster; 35th All Ireland Schools Conference ; Conference date: 25-03-2013 Through 26-03-2013",
year = "2013",
language = "English",

}

Wilson, M, Andrews, GP & Jones, DS 2013, 'Hot melt extruded HPC based formulations to control drug release' 35th All Ireland Schools Conference, Belfast, Northern Ireland, 25/03/13 - 26/03/13, .

Hot melt extruded HPC based formulations to control drug release. / Wilson, Matthew; Andrews, G. P.; Jones, DS.

2013. Abstract from 35th All Ireland Schools Conference, Belfast, Northern Ireland.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Hot melt extruded HPC based formulations to control drug release

AU - Wilson, Matthew

AU - Andrews, G. P.

AU - Jones, DS

N1 - Conference paper and poster

PY - 2013

Y1 - 2013

N2 - Over the last five years there has been a growing interest in the capabilities of Hot Melt Extrusion (HME) for the rapid production of solid oral dosage forms to provide sustained or controlled release (1). Many of the polymers used in production form hydrogels some of which respond to temperature. At the Low Critical Solution Temperature (LCST), there is an abrupt phase transition as the hydrophobic groups align and cause the gel to collapse and shrink(2). LCST materials can force out the drug as the gel shrinks.This study details the application of HME formulations containing Hydroxypropylcellulose (HPC) as a base polymer using a combination of Methylcellulose (MC) and Hydroxypropylmethylcellulose (HPMC). The limit to which formulation controlled drug release under varying hydrodynamic effects, high alcohol environments and high and low drug loads were investigated using.

AB - Over the last five years there has been a growing interest in the capabilities of Hot Melt Extrusion (HME) for the rapid production of solid oral dosage forms to provide sustained or controlled release (1). Many of the polymers used in production form hydrogels some of which respond to temperature. At the Low Critical Solution Temperature (LCST), there is an abrupt phase transition as the hydrophobic groups align and cause the gel to collapse and shrink(2). LCST materials can force out the drug as the gel shrinks.This study details the application of HME formulations containing Hydroxypropylcellulose (HPC) as a base polymer using a combination of Methylcellulose (MC) and Hydroxypropylmethylcellulose (HPMC). The limit to which formulation controlled drug release under varying hydrodynamic effects, high alcohol environments and high and low drug loads were investigated using.

M3 - Abstract

ER -

Wilson M, Andrews GP, Jones DS. Hot melt extruded HPC based formulations to control drug release. 2013. Abstract from 35th All Ireland Schools Conference, Belfast, Northern Ireland.