Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration

Amy Nommeots-nomm, Sheyda Labbaf, Aine Devlin, Naomi Todd, Hua Geng, Anu K. Solanki, Hok Man Tang, Polytimi Perdika, Alessandra Pinna, Fatemeh Ejeian, Olga Tsigkou, Peter D. Lee, Mohammad Hossein Nasr Esfahani, Christopher A. Mitchell, Julian R. Jones

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)
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A challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnected pores while maintaining the amorphous nature of the glass and its associated bioactivity. Here we introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silica content and report in vitro and preliminary in vivo data. The gel-cast foaming process was adapted, employing temperature controlled gelation of gelatin, rather than the in situ acrylic polymerisation used previously. To form a 3D construct from melt derived glasses, particles must be fused via thermal processing, termed sintering. The original Bioglass® 45S5 composition crystallises upon sintering, altering its bioactivity, due to the temperature difference between the glass transition temperature and the crystallisation onset being small. Here, we optimised and compared scaffolds from three glass compositions, ICIE16, PSrBG and 13–93, which were selected due to their widened sintering windows. Amorphous scaffolds with modal pore interconnect diameters between 100–150 µm and porosities of 75% had compressive strengths of 3.4 ± 0.3 MPa, 8.4 ± 0.8 MPa and 15.3 ± 1.8 MPa, for ICIE16, PSrBG and 13–93 respectively. These porosities and compressive strength values are within the range of cancellous bone, and greater than previously reported foamed scaffolds. Dental pulp stem cells attached to the scaffold surfaces during in vitro culture and were viable. In vivo, the scaffolds were found to regenerate bone in a rabbit model according to X-ray micro tomography imaging.
Original languageEnglish
Pages (from-to)449-461
Number of pages12
JournalActa Biomaterialia
Early online date27 Apr 2017
Publication statusPublished (in print/issue) - 15 Jul 2017


  • Bioactive glass
  • Bioglass
  • Bone regeneration
  • Rabbit model
  • Scaffold


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