Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnectedpores while maintaining the amorphous nature of the glass and its associated bioactivity. Herewe introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silicacontent and report in vitro and preliminary in vivo data. The gel-cast foaming process was adapted,employing temperature controlled gelation of gelatin, rather than the in situ acrylic polymerisation usedpreviously. To form a 3D construct from melt derived glasses, particles must be fused via thermal processing,termed sintering. The original Bioglass� 45S5 composition crystallises upon sintering, alteringits bioactivity, due to the temperature difference between the glass transition temperature and the crystallisationonset being small. Here, we optimised and compared scaffolds from three glass compositions,ICIE16, PSrBG and 13–93, which were selected due to their widened sintering windows. Amorphous scaffoldswith modal pore interconnect diameters between 100–150 mm and porosities of 75% had compressivestrengths of 3.4 ± 0.3 MPa, 8.4 ± 0.8 MPa and 15.3 ± 1.8 MPa, for ICIE16, PSrBG and 13–93respectively. These porosities and compressive strength values are within the range of cancellous bone,and greater than previously reported foamed scaffolds. Dental pulp stem cells attached to the scaffoldsurfaces during in vitro culture and were viable. In vivo, the scaffolds were found to regenerate bone ina rabbit model according to X-ray micro tomography imaging.
LanguageEnglish
Pages449-461
Number of pages12
JournalActa Biomaterialia
Volume57
Early online date27 Apr 2017
DOIs
Publication statusPublished - 15 Jul 2017

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Bone Regeneration
Glass
Porosity
X Ray Tomography
Compressive Strength
Dental Pulp
Temperature
Transition Temperature
Gelatin
Polymerization
Stem Cells
Hot Temperature
Gels
Rabbits
Bone and Bones

Keywords

  • Bioactive glass
  • Bioglass
  • Bone regeneration
  • Rabbit model
  • Scaffold

Cite this

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abstract = "A challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnectedpores while maintaining the amorphous nature of the glass and its associated bioactivity. Herewe introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silicacontent and report in vitro and preliminary in vivo data. The gel-cast foaming process was adapted,employing temperature controlled gelation of gelatin, rather than the in situ acrylic polymerisation usedpreviously. To form a 3D construct from melt derived glasses, particles must be fused via thermal processing,termed sintering. The original Bioglass� 45S5 composition crystallises upon sintering, alteringits bioactivity, due to the temperature difference between the glass transition temperature and the crystallisationonset being small. Here, we optimised and compared scaffolds from three glass compositions,ICIE16, PSrBG and 13–93, which were selected due to their widened sintering windows. Amorphous scaffoldswith modal pore interconnect diameters between 100–150 mm and porosities of 75{\%} had compressivestrengths of 3.4 ± 0.3 MPa, 8.4 ± 0.8 MPa and 15.3 ± 1.8 MPa, for ICIE16, PSrBG and 13–93respectively. These porosities and compressive strength values are within the range of cancellous bone,and greater than previously reported foamed scaffolds. Dental pulp stem cells attached to the scaffoldsurfaces during in vitro culture and were viable. In vivo, the scaffolds were found to regenerate bone ina rabbit model according to X-ray micro tomography imaging.",
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Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration. / Mitchell, CA.

In: Acta Biomaterialia, Vol. 57, 15.07.2017, p. 449-461.

Research output: Contribution to journalArticle

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