Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies – data from the EUROlinkCAT study

Stine  Kjær Urhøj; Joan Morris; Maria Loane; Elisa Ballardini; Laia Barrachina-Bonet; Clara Cavero‑Carbonell; Alessio Coi; Mika Gissler; Joanne Given; Anna Heino; Sue Jordan; Amanda  Neville; Michele Santoro; Joachim Tan; David Tucker; Diana Wellesley; Garne Ester; Mads  Damkjær

doi:10.1111/apa.17136

Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies – data from the EUROlinkCAT study

Stine Kjær Urhøj, Joan Morris, Maria Loane, Elisa Ballardini, Laia Barrachina-Bonet, Clara Cavero‑Carbonell, Alessio Coi, Mika Gissler, Joanne Given, Anna Heino, Sue Jordan, Amanda Neville, Michele Santoro, Joachim Tan, David Tucker, Diana Wellesley, Garne Ester, Mads Damkjær

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

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Abstract

Aim
The aim is to examine the risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10 years.

Methods
This is a population-based data linkage cohort study linking information from the European Surveillance of Congenital Anomalies network (EUROCAT) and birth registries to hospital discharge databases. We included 91 504 live born children with major congenital anomalies born from 1995 to 2014 from nine EUROCAT registries in five countries and 1 960 727 live born children without congenital anomalies (reference children). Prevalence and relative risk (RR) were estimated for each of the co-morbidities using Kaplan–Meier survival estimates.

Results
Children with congenital anomalies had higher risks of the co-morbidities than reference children. The prevalences in the reference children were generally very low. The RR was 13.8 (95% CI 12.5–15.1) for cerebral palsy, 2.5 (95% CI 2.4–2.6) for seizures/epilepsy, 40.8 (95% CI 33.2–50.2) for visual impairments, 10.0 (95% CI 9.2–10.9) for hearing loss, 3.6 (95% CI 3.2–4.2) for cancer, 1.5 (95% CI 1.4–1.5) for injuries/poisoning and 2.4 (95% CI 1.7–3.4) for child abuse.

Conclusion
Children with congenital anomalies were more likely to be diagnosed with the specified co-morbidities compared to reference children.

Original language	English
Pages (from-to)	1024-1031
Number of pages	8
Journal	Acta Paediatrica
Volume	113
Issue number	5
Early online date	7 Feb 2024
DOIs	https://doi.org/10.1111/apa.17136
Publication status	Published (in print/issue) - 10 Apr 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

Keywords

cerebral palsy
congenital anomalies
injuries and poisoning

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/apa.17136

Acta Paediatrica - 2024 - Urhoj - Higher risk of cerebral palsy seizures epilepsy visual‐ and hearing impairments cancerFinal published version, 800 KBLicence: CC BY-NC

https://doi.org/10.1111/apa.17136

Cite this

Kjær Urhøj, S., Morris, J., Loane, M., Ballardini, E., Barrachina-Bonet, L., Cavero‑Carbonell, C., Coi, A., Gissler, M., Given, J., Heino, A., Jordan, S., Neville, A., Santoro, M., Tan, J., Tucker, D., Wellesley, D., Ester, G., & Damkjær, M. (2024). Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies – data from the EUROlinkCAT study. Acta Paediatrica, 113(5), 1024-1031. https://doi.org/10.1111/apa.17136

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title = "Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies – data from the EUROlinkCAT study",

abstract = "AimThe aim is to examine the risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10 years.MethodsThis is a population-based data linkage cohort study linking information from the European Surveillance of Congenital Anomalies network (EUROCAT) and birth registries to hospital discharge databases. We included 91 504 live born children with major congenital anomalies born from 1995 to 2014 from nine EUROCAT registries in five countries and 1 960 727 live born children without congenital anomalies (reference children). Prevalence and relative risk (RR) were estimated for each of the co-morbidities using Kaplan–Meier survival estimates.ResultsChildren with congenital anomalies had higher risks of the co-morbidities than reference children. The prevalences in the reference children were generally very low. The RR was 13.8 (95% CI 12.5–15.1) for cerebral palsy, 2.5 (95% CI 2.4–2.6) for seizures/epilepsy, 40.8 (95% CI 33.2–50.2) for visual impairments, 10.0 (95% CI 9.2–10.9) for hearing loss, 3.6 (95% CI 3.2–4.2) for cancer, 1.5 (95% CI 1.4–1.5) for injuries/poisoning and 2.4 (95% CI 1.7–3.4) for child abuse.ConclusionChildren with congenital anomalies were more likely to be diagnosed with the specified co-morbidities compared to reference children.",

keywords = "cerebral palsy, congenital anomalies, injuries and poisoning",

author = "{Kj{\ae}r Urh{\o}j}, Stine and Joan Morris and Maria Loane and Elisa Ballardini and Laia Barrachina-Bonet and Clara Cavero‑Carbonell and Alessio Coi and Mika Gissler and Joanne Given and Anna Heino and Sue Jordan and Amanda Neville and Michele Santoro and Joachim Tan and David Tucker and Diana Wellesley and Garne Ester and Mads Damkj{\ae}r",

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Kjær Urhøj, S, Morris, J, Loane, M, Ballardini, E, Barrachina-Bonet, L, Cavero‑Carbonell, C, Coi, A, Gissler, M, Given, J, Heino, A, Jordan, S, Neville, A, Santoro, M, Tan, J, Tucker, D, Wellesley, D, Ester, G & Damkjær, M 2024, 'Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies – data from the EUROlinkCAT study', Acta Paediatrica, vol. 113, no. 5, pp. 1024-1031. https://doi.org/10.1111/apa.17136

Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies – data from the EUROlinkCAT study. / Kjær Urhøj, Stine ; Morris, Joan; Loane, Maria et al.
In: Acta Paediatrica, Vol. 113, No. 5, 10.04.2024, p. 1024-1031.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies – data from the EUROlinkCAT study

AU - Kjær Urhøj, Stine

AU - Morris, Joan

AU - Loane, Maria

AU - Ballardini, Elisa

AU - Barrachina-Bonet, Laia

AU - Cavero‑Carbonell, Clara

AU - Coi, Alessio

AU - Gissler, Mika

AU - Given, Joanne

AU - Heino, Anna

AU - Jordan, Sue

AU - Neville, Amanda

AU - Santoro, Michele

AU - Tan, Joachim

AU - Tucker, David

AU - Wellesley, Diana

AU - Ester, Garne

AU - Damkjær, Mads

PY - 2024/4/10

Y1 - 2024/4/10

N2 - AimThe aim is to examine the risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10 years.MethodsThis is a population-based data linkage cohort study linking information from the European Surveillance of Congenital Anomalies network (EUROCAT) and birth registries to hospital discharge databases. We included 91 504 live born children with major congenital anomalies born from 1995 to 2014 from nine EUROCAT registries in five countries and 1 960 727 live born children without congenital anomalies (reference children). Prevalence and relative risk (RR) were estimated for each of the co-morbidities using Kaplan–Meier survival estimates.ResultsChildren with congenital anomalies had higher risks of the co-morbidities than reference children. The prevalences in the reference children were generally very low. The RR was 13.8 (95% CI 12.5–15.1) for cerebral palsy, 2.5 (95% CI 2.4–2.6) for seizures/epilepsy, 40.8 (95% CI 33.2–50.2) for visual impairments, 10.0 (95% CI 9.2–10.9) for hearing loss, 3.6 (95% CI 3.2–4.2) for cancer, 1.5 (95% CI 1.4–1.5) for injuries/poisoning and 2.4 (95% CI 1.7–3.4) for child abuse.ConclusionChildren with congenital anomalies were more likely to be diagnosed with the specified co-morbidities compared to reference children.

AB - AimThe aim is to examine the risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10 years.MethodsThis is a population-based data linkage cohort study linking information from the European Surveillance of Congenital Anomalies network (EUROCAT) and birth registries to hospital discharge databases. We included 91 504 live born children with major congenital anomalies born from 1995 to 2014 from nine EUROCAT registries in five countries and 1 960 727 live born children without congenital anomalies (reference children). Prevalence and relative risk (RR) were estimated for each of the co-morbidities using Kaplan–Meier survival estimates.ResultsChildren with congenital anomalies had higher risks of the co-morbidities than reference children. The prevalences in the reference children were generally very low. The RR was 13.8 (95% CI 12.5–15.1) for cerebral palsy, 2.5 (95% CI 2.4–2.6) for seizures/epilepsy, 40.8 (95% CI 33.2–50.2) for visual impairments, 10.0 (95% CI 9.2–10.9) for hearing loss, 3.6 (95% CI 3.2–4.2) for cancer, 1.5 (95% CI 1.4–1.5) for injuries/poisoning and 2.4 (95% CI 1.7–3.4) for child abuse.ConclusionChildren with congenital anomalies were more likely to be diagnosed with the specified co-morbidities compared to reference children.

KW - cerebral palsy

KW - congenital anomalies

KW - injuries and poisoning

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U2 - 10.1111/apa.17136

DO - 10.1111/apa.17136

M3 - Article

C2 - 38324400

SN - 0803-5253

VL - 113

SP - 1024

EP - 1031

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 5

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Kjær Urhøj S, Morris J, Loane M, Ballardini E, Barrachina-Bonet L, Cavero‑Carbonell C et al. Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies – data from the EUROlinkCAT study. Acta Paediatrica. 2024 Apr 10;113(5):1024-1031. Epub 2024 Feb 7. doi: 10.1111/apa.17136

Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies – data from the EUROlinkCAT study

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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Creating a population-based cohort of children born with and without congenital anomalies using birth data matched to hospital discharge databases in 11 European regions: Assessment of linkage success and data quality

Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study

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