Higher Order Aberrations in Children with Down Syndrome

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Abstract

Purpose: Down syndrome (DS) is associated with ocular abnormalities and reduced visual function. Studies report atypical optical structures in the DS eye such as thinner, steeper corneae and thinner crystalline lenses and, functionally, a degrading influence of the optics on resolution acuity. The present study further investigates optical quality in DS by comparing higher order ocular aberrations (HOA) in DS and control eyes.Methods: Participants were 44 children with DS (6-16 years) and 209 age-matched controls. All participants were free from corneal or lenticular pathology. HOA were measured following cycloplegia using Shack-Hartmann aberrometry. HOA were analysed over a 3mm and 5mm pupil using Zernike polynomials from 3rd to 6th order. Optical quality was explored using Visual Strehl ratios (VSX) and equivalent defocus values. Results: HOA were measured successfully from 68% of the DS group and 95% of controls. Root mean square of total combined HOA, third and sixth orders and coma were significantly greater in the DS group (p
LanguageEnglish
Pages1527-1535
JournalInvestigative Ophthalmology and Visual Science
Volume54
Issue number2
DOIs
Publication statusPublished - 28 Feb 2013

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Down Syndrome
Aberrometry
Eye Abnormalities
Crystalline Lens
Pupil
Coma
Cornea
Pathology
Control Groups

Cite this

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title = "Higher Order Aberrations in Children with Down Syndrome",
abstract = "Purpose: Down syndrome (DS) is associated with ocular abnormalities and reduced visual function. Studies report atypical optical structures in the DS eye such as thinner, steeper corneae and thinner crystalline lenses and, functionally, a degrading influence of the optics on resolution acuity. The present study further investigates optical quality in DS by comparing higher order ocular aberrations (HOA) in DS and control eyes.Methods: Participants were 44 children with DS (6-16 years) and 209 age-matched controls. All participants were free from corneal or lenticular pathology. HOA were measured following cycloplegia using Shack-Hartmann aberrometry. HOA were analysed over a 3mm and 5mm pupil using Zernike polynomials from 3rd to 6th order. Optical quality was explored using Visual Strehl ratios (VSX) and equivalent defocus values. Results: HOA were measured successfully from 68{\%} of the DS group and 95{\%} of controls. Root mean square of total combined HOA, third and sixth orders and coma were significantly greater in the DS group (p",
author = "Sara McCullough and Julie-Anne Little and Kathryn Saunders",
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day = "28",
doi = "10.1167/iovs.12-10597",
language = "English",
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pages = "1527--1535",
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TY - JOUR

T1 - Higher Order Aberrations in Children with Down Syndrome

AU - McCullough, Sara

AU - Little, Julie-Anne

AU - Saunders, Kathryn

PY - 2013/2/28

Y1 - 2013/2/28

N2 - Purpose: Down syndrome (DS) is associated with ocular abnormalities and reduced visual function. Studies report atypical optical structures in the DS eye such as thinner, steeper corneae and thinner crystalline lenses and, functionally, a degrading influence of the optics on resolution acuity. The present study further investigates optical quality in DS by comparing higher order ocular aberrations (HOA) in DS and control eyes.Methods: Participants were 44 children with DS (6-16 years) and 209 age-matched controls. All participants were free from corneal or lenticular pathology. HOA were measured following cycloplegia using Shack-Hartmann aberrometry. HOA were analysed over a 3mm and 5mm pupil using Zernike polynomials from 3rd to 6th order. Optical quality was explored using Visual Strehl ratios (VSX) and equivalent defocus values. Results: HOA were measured successfully from 68% of the DS group and 95% of controls. Root mean square of total combined HOA, third and sixth orders and coma were significantly greater in the DS group (p

AB - Purpose: Down syndrome (DS) is associated with ocular abnormalities and reduced visual function. Studies report atypical optical structures in the DS eye such as thinner, steeper corneae and thinner crystalline lenses and, functionally, a degrading influence of the optics on resolution acuity. The present study further investigates optical quality in DS by comparing higher order ocular aberrations (HOA) in DS and control eyes.Methods: Participants were 44 children with DS (6-16 years) and 209 age-matched controls. All participants were free from corneal or lenticular pathology. HOA were measured following cycloplegia using Shack-Hartmann aberrometry. HOA were analysed over a 3mm and 5mm pupil using Zernike polynomials from 3rd to 6th order. Optical quality was explored using Visual Strehl ratios (VSX) and equivalent defocus values. Results: HOA were measured successfully from 68% of the DS group and 95% of controls. Root mean square of total combined HOA, third and sixth orders and coma were significantly greater in the DS group (p

U2 - 10.1167/iovs.12-10597

DO - 10.1167/iovs.12-10597

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JO - Investigative Ophthalmology and Visual Science

T2 - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

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