High throughput engineering and use of multi-fiber composite matrices for controlled active release

Li Wang, Chunchen Zhang, Hui Min David Wang, Zeeshan Ahmad, Jing Song Li, Ming Wei Chang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalMaterials Today Communications
Volume17
Early online date18 Aug 2018
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Alignment
  • Centrifugal electrospinning
  • Composite fibers
  • Drug release
  • Regulation

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