High throughput engineering and use of multi-fiber composite matrices for controlled active release

Li Wang; Chunchen Zhang; Hui Min David Wang; Zeeshan Ahmad; Jing Song Li; Ming Wei Chang

doi:10.1016/j.mtcomm.2018.08.011

High throughput engineering and use of multi-fiber composite matrices for controlled active release

Li Wang, Chunchen Zhang, Hui Min David Wang, Zeeshan Ahmad, Jing Song Li, Ming Wei Chang

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.

Original language	English
Pages (from-to)	53-59
Number of pages	7
Journal	Materials Today Communications
Volume	17
Early online date	18 Aug 2018
DOIs	https://doi.org/10.1016/j.mtcomm.2018.08.011
Publication status	Published (in print/issue) - 1 Dec 2018

Keywords

Alignment
Centrifugal electrospinning
Composite fibers
Drug release
Regulation

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10.1016/j.mtcomm.2018.08.011

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title = "High throughput engineering and use of multi-fiber composite matrices for controlled active release",

abstract = "A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.",

keywords = "Alignment, Centrifugal electrospinning, Composite fibers, Drug release, Regulation",

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AU - Wang, Li

AU - Zhang, Chunchen

AU - Wang, Hui Min David

AU - Ahmad, Zeeshan

AU - Li, Jing Song

AU - Chang, Ming Wei

PY - 2018/12/1

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N2 - A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.

AB - A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.

KW - Alignment

KW - Centrifugal electrospinning

KW - Composite fibers

KW - Drug release

KW - Regulation

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SN - 2352-4928

VL - 17

SP - 53

EP - 59

JO - Materials Today Communications

JF - Materials Today Communications

ER -

High throughput engineering and use of multi-fiber composite matrices for controlled active release

Abstract

Keywords

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