High throughput engineering and use of multi-fiber composite matrices for controlled active release

Li Wang, Chunchen Zhang, Hui Min David Wang, Zeeshan Ahmad, Jing Song Li, Ming Wei Chang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.

LanguageEnglish
Pages53-59
Number of pages7
JournalMaterials Today Communications
Volume17
Early online date18 Aug 2018
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint

Throughput
Membranes
Fibers
Composite materials
Polyvinyls
Pyrrolidinones
Polyurethanes
Electrospinning
Polymethyl Methacrylate
Chemical analysis
Polymethyl methacrylates
Pharmaceutical Preparations
Thermoplastics
Contact angle
Water

Keywords

  • Alignment
  • Centrifugal electrospinning
  • Composite fibers
  • Drug release
  • Regulation

Cite this

@article{b5827a93ed2d435c8977649107c7a63a,
title = "High throughput engineering and use of multi-fiber composite matrices for controlled active release",
abstract = "A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.",
keywords = "Alignment, Centrifugal electrospinning, Composite fibers, Drug release, Regulation",
author = "Li Wang and Chunchen Zhang and Wang, {Hui Min David} and Zeeshan Ahmad and Li, {Jing Song} and Chang, {Ming Wei}",
note = "No accepted version, not for REF. Ming-Wei was not employed in the UK at time of acceptance or publication.",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.mtcomm.2018.08.011",
language = "English",
volume = "17",
pages = "53--59",
journal = "Materials Today Communications",
issn = "2352-4928",
publisher = "Elsevier BV",

}

High throughput engineering and use of multi-fiber composite matrices for controlled active release. / Wang, Li; Zhang, Chunchen; Wang, Hui Min David; Ahmad, Zeeshan; Li, Jing Song; Chang, Ming Wei.

In: Materials Today Communications, Vol. 17, 01.12.2018, p. 53-59.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High throughput engineering and use of multi-fiber composite matrices for controlled active release

AU - Wang, Li

AU - Zhang, Chunchen

AU - Wang, Hui Min David

AU - Ahmad, Zeeshan

AU - Li, Jing Song

AU - Chang, Ming Wei

N1 - No accepted version, not for REF. Ming-Wei was not employed in the UK at time of acceptance or publication.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.

AB - A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.

KW - Alignment

KW - Centrifugal electrospinning

KW - Composite fibers

KW - Drug release

KW - Regulation

UR - http://www.scopus.com/inward/record.url?scp=85052232914&partnerID=8YFLogxK

U2 - 10.1016/j.mtcomm.2018.08.011

DO - 10.1016/j.mtcomm.2018.08.011

M3 - Article

VL - 17

SP - 53

EP - 59

JO - Materials Today Communications

T2 - Materials Today Communications

JF - Materials Today Communications

SN - 2352-4928

ER -