High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

Samuel Lawman; Yue Dong; Bryan M. Williams; Vito Romano; Stephen Kaye; Simon P. Harding; Colin Willoughby; Yao-Chun Shen; Yalin Zheng

doi:10.1364/OE.24.012395

High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

Samuel Lawman, Yue Dong, Bryan M. Williams, Vito Romano, Stephen Kaye, Simon P. Harding, Colin Willoughby, Yao-Chun Shen, Yalin Zheng

Research output: Contribution to journal › Article › peer-review

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Abstract

We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.

Original language	English
Pages (from-to)	12395
Journal	Optics Express
Volume	24
Issue number	11
DOIs	https://doi.org/10.1364/OE.24.012395
Publication status	Accepted/In press - 23 May 2016

Keywords

OCT
cornea
imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1364/OE.24.012395

Oe-24-11-12395Final published version, 1.9 MB

Cite this

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title = "High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography",

abstract = "We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.",

keywords = "OCT, cornea, imaging",

author = "Samuel Lawman and Yue Dong and Williams, {Bryan M.} and Vito Romano and Stephen Kaye and Harding, {Simon P.} and Colin Willoughby and Yao-Chun Shen and Yalin Zheng",

year = "2016",

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T1 - High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

AU - Lawman, Samuel

AU - Dong, Yue

AU - Williams, Bryan M.

AU - Romano, Vito

AU - Kaye, Stephen

AU - Harding, Simon P.

AU - Willoughby, Colin

AU - Shen, Yao-Chun

AU - Zheng, Yalin

PY - 2016/5/23

Y1 - 2016/5/23

N2 - We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.

AB - We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.

KW - OCT

KW - cornea

KW - imaging

U2 - 10.1364/OE.24.012395

DO - 10.1364/OE.24.012395

M3 - Article

SN - 1094-4087

VL - 24

SP - 12395

JO - Optics Express

JF - Optics Express

IS - 11

ER -

High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

Abstract

Keywords

UN SDGs

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