High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

Samuel Lawman, Yue Dong, Bryan M. Williams, Vito Romano, Stephen Kaye, Simon P. Harding, Colin Willoughby, Yao-Chun Shen, Yalin Zheng

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.
    LanguageEnglish
    Pages12395
    JournalOptics Express
    Volume24
    Issue number11
    DOIs
    Publication statusAccepted/In press - 23 May 2016

    Fingerprint

    tomography
    continuous radiation
    high resolution
    pulses
    continuums
    tablets
    cornea
    white noise
    artifacts
    aberration
    fine structure
    bandwidth
    air

    Keywords

    • OCT
    • cornea
    • imaging

    Cite this

    Lawman, S., Dong, Y., Williams, B. M., Romano, V., Kaye, S., Harding, S. P., ... Zheng, Y. (Accepted/In press). High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography. Optics Express, 24(11), 12395. https://doi.org/10.1364/OE.24.012395
    Lawman, Samuel ; Dong, Yue ; Williams, Bryan M. ; Romano, Vito ; Kaye, Stephen ; Harding, Simon P. ; Willoughby, Colin ; Shen, Yao-Chun ; Zheng, Yalin. / High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography. In: Optics Express. 2016 ; Vol. 24, No. 11. pp. 12395.
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    abstract = "We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.",
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    Lawman, S, Dong, Y, Williams, BM, Romano, V, Kaye, S, Harding, SP, Willoughby, C, Shen, Y-C & Zheng, Y 2016, 'High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography', Optics Express, vol. 24, no. 11, pp. 12395. https://doi.org/10.1364/OE.24.012395

    High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography. / Lawman, Samuel; Dong, Yue; Williams, Bryan M.; Romano, Vito; Kaye, Stephen; Harding, Simon P.; Willoughby, Colin; Shen, Yao-Chun; Zheng, Yalin.

    In: Optics Express, Vol. 24, No. 11, 23.05.2016, p. 12395.

    Research output: Contribution to journalArticle

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    AU - Dong, Yue

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    AU - Kaye, Stephen

    AU - Harding, Simon P.

    AU - Willoughby, Colin

    AU - Shen, Yao-Chun

    AU - Zheng, Yalin

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    AB - We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.

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