Hemodynamic and structural brain measures in high and low sedentary older adults

Carlijn M. Maasakkers; Dick H.J. Thijssen; Silvin P. Knight; Louise Newman; John D. O'Connor; Siobhan Scarlett; Daniel Carey; Anne Buckley; Jason P. McMorrow; Caoilfhionn Ní Leidhin; Joanne Feeney; René J.F. Melis; Rose Anne Kenny; Jurgen A.H.R. Claassen; Céline De Looze

doi:10.1177/0271678X211009382

Hemodynamic and structural brain measures in high and low sedentary older adults

Carlijn M. Maasakkers
, Dick H.J. Thijssen
, Silvin P. Knight
, Louise Newman
, John D. O'Connor
, Siobhan Scarlett
, Daniel Carey
, Anne Buckley
, Jason P. McMorrow
, Caoilfhionn Ní Leidhin
, Joanne Feeney
, René J.F. Melis
, Rose Anne Kenny
, Jurgen A.H.R. Claassen
, Céline De Looze

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

17 Downloads (Pure)

Abstract

Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain abnormalities associated with cognitive decline. We therefore assessed the association between sedentary behaviour and brain measures of cerebrovascular perfusion and structural abnormalities in community-dwelling older adults. Using accelerometery (GENEActiv) data from The Irish Longitudinal Study on Ageing (TILDA) we categorised individuals by low- and high-sedentary behaviour (≤8 vs >8 hours/day). We examined prefrontal haemoglobin oxygenation levels using Near-Infrared Spectroscopy during rest and after an orthostatic challenge in 718 individuals (66 ± 8 years, 52% female). Global grey matter cerebral blood flow, total grey and white matter volume, total and subfield hippocampal volumes, cortical thickness, and white matter hyperintensities were measured using arterial spin labelling, T1, and FLAIR MRI in 86 individuals (72 ± 6 years, 55% female). While no differences in prefrontal or global cerebral hemodynamics were found between groups, high-sedentary individuals showed lower hippocampal volumes and increased white matter hyperintensities compared to their low-sedentary counterparts. Since these structural cerebral abnormalities are associated with cognitive decline and Alzheimer’s disease, future work exploring the causal pathways underlying these differences is needed.

Original language	English
Pages (from-to)	2607-2616
Number of pages	10
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	41
Issue number	10
Early online date	17 Apr 2021
DOIs	https://doi.org/10.1177/0271678X211009382
Publication status	Published (in print/issue) - 1 Oct 2021

Bibliographical note

Publisher Copyright:
© The Author(s) 2021.

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: TILDA is funded by the Department of Health, Irish Life, and The Atlantic Philanthropies. MRI data collection was funded by the Health Research Board (HRB) [HRA-PHR-2014-667] and supported by the National Centre for Advanced Medical Imaging (CAMI). CM was supported by a personal international research internship grant awarded by Alzheimer Nederland. Sponsors played no role in the design, execution, analysis and interpretation of data, or writing of the paper.

Keywords

Alzheimer’s disease
cognitive decline
hemodynamics
neuroimaging
sedentary behaviour

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Maasakkers, C. M., Thijssen, D. H. J., Knight, S. P., Newman, L., O'Connor, J. D., Scarlett, S., Carey, D., Buckley, A., McMorrow, J. P., Leidhin, C. N., Feeney, J., Melis, R. J. F., Kenny, R. A., Claassen, J. A. H. R., & Looze, C. D. (2021). Hemodynamic and structural brain measures in high and low sedentary older adults. Journal of Cerebral Blood Flow and Metabolism, 41(10), 2607-2616. https://doi.org/10.1177/0271678X211009382

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abstract = "Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain abnormalities associated with cognitive decline. We therefore assessed the association between sedentary behaviour and brain measures of cerebrovascular perfusion and structural abnormalities in community-dwelling older adults. Using accelerometery (GENEActiv) data from The Irish Longitudinal Study on Ageing (TILDA) we categorised individuals by low- and high-sedentary behaviour (≤8 vs >8 hours/day). We examined prefrontal haemoglobin oxygenation levels using Near-Infrared Spectroscopy during rest and after an orthostatic challenge in 718 individuals (66 ± 8 years, 52\% female). Global grey matter cerebral blood flow, total grey and white matter volume, total and subfield hippocampal volumes, cortical thickness, and white matter hyperintensities were measured using arterial spin labelling, T1, and FLAIR MRI in 86 individuals (72 ± 6 years, 55\% female). While no differences in prefrontal or global cerebral hemodynamics were found between groups, high-sedentary individuals showed lower hippocampal volumes and increased white matter hyperintensities compared to their low-sedentary counterparts. Since these structural cerebral abnormalities are associated with cognitive decline and Alzheimer{\textquoteright}s disease, future work exploring the causal pathways underlying these differences is needed.",

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Maasakkers, CM, Thijssen, DHJ, Knight, SP, Newman, L, O'Connor, JD, Scarlett, S, Carey, D, Buckley, A, McMorrow, JP, Leidhin, CN, Feeney, J, Melis, RJF, Kenny, RA, Claassen, JAHR & Looze, CD 2021, 'Hemodynamic and structural brain measures in high and low sedentary older adults', Journal of Cerebral Blood Flow and Metabolism, vol. 41, no. 10, pp. 2607-2616. https://doi.org/10.1177/0271678X211009382

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AU - Maasakkers, Carlijn M.

AU - Thijssen, Dick H.J.

AU - Knight, Silvin P.

AU - Newman, Louise

AU - O'Connor, John D.

AU - Scarlett, Siobhan

AU - Carey, Daniel

AU - Buckley, Anne

AU - McMorrow, Jason P.

AU - Leidhin, Caoilfhionn Ní

AU - Feeney, Joanne

AU - Melis, René J.F.

AU - Kenny, Rose Anne

AU - Claassen, Jurgen A.H.R.

AU - Looze, Céline De

PY - 2021/10/1

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N2 - Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain abnormalities associated with cognitive decline. We therefore assessed the association between sedentary behaviour and brain measures of cerebrovascular perfusion and structural abnormalities in community-dwelling older adults. Using accelerometery (GENEActiv) data from The Irish Longitudinal Study on Ageing (TILDA) we categorised individuals by low- and high-sedentary behaviour (≤8 vs >8 hours/day). We examined prefrontal haemoglobin oxygenation levels using Near-Infrared Spectroscopy during rest and after an orthostatic challenge in 718 individuals (66 ± 8 years, 52% female). Global grey matter cerebral blood flow, total grey and white matter volume, total and subfield hippocampal volumes, cortical thickness, and white matter hyperintensities were measured using arterial spin labelling, T1, and FLAIR MRI in 86 individuals (72 ± 6 years, 55% female). While no differences in prefrontal or global cerebral hemodynamics were found between groups, high-sedentary individuals showed lower hippocampal volumes and increased white matter hyperintensities compared to their low-sedentary counterparts. Since these structural cerebral abnormalities are associated with cognitive decline and Alzheimer’s disease, future work exploring the causal pathways underlying these differences is needed.

AB - Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain abnormalities associated with cognitive decline. We therefore assessed the association between sedentary behaviour and brain measures of cerebrovascular perfusion and structural abnormalities in community-dwelling older adults. Using accelerometery (GENEActiv) data from The Irish Longitudinal Study on Ageing (TILDA) we categorised individuals by low- and high-sedentary behaviour (≤8 vs >8 hours/day). We examined prefrontal haemoglobin oxygenation levels using Near-Infrared Spectroscopy during rest and after an orthostatic challenge in 718 individuals (66 ± 8 years, 52% female). Global grey matter cerebral blood flow, total grey and white matter volume, total and subfield hippocampal volumes, cortical thickness, and white matter hyperintensities were measured using arterial spin labelling, T1, and FLAIR MRI in 86 individuals (72 ± 6 years, 55% female). While no differences in prefrontal or global cerebral hemodynamics were found between groups, high-sedentary individuals showed lower hippocampal volumes and increased white matter hyperintensities compared to their low-sedentary counterparts. Since these structural cerebral abnormalities are associated with cognitive decline and Alzheimer’s disease, future work exploring the causal pathways underlying these differences is needed.

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KW - cognitive decline

KW - hemodynamics

KW - neuroimaging

KW - sedentary behaviour

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JF - Journal of Cerebral Blood Flow and Metabolism

IS - 10

ER -

Hemodynamic and structural brain measures in high and low sedentary older adults

Abstract

Bibliographical note

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Keywords

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