HELICOBACTER-PYLORI INFECTION - RELATION WITH CARDIOVASCULAR RISK-FACTORS, ISCHEMIC-HEART-DISEASE, AND SOCIAL-CLASS

LJ MURRAY, KB BAMFORD, DPJ OREILLY, EE MCCRUM, AE EVANS

    Research output: Contribution to journalArticle

    Abstract

    Objective-To determine whether Helicobacter pylori infection is associated with the development of ischaemic heart disease and whether such infection can explain the social class inequality in ischaemic heart disease. Design-Cardiovascular risk factor levels, prevalence of ischaemic heart disease (Rose questionnaire angina, and/or a history of myocardial infarction), and serum antibodies to H pylori (enzyme linked immunosorbent assay) were assessed in a cross sectional population based survey. Setting-Belfast and surrounding districts, Northern Ireland. Participants-1182 men and 1198 women aged 25-64 years randomly selected from the Central Services Agency's general practitioner lists. Main outcome measures-The relation of H pylori infection with cardiovascular risk factors and ischaemic heart disease. The association of social class with ischaemic heart disease. Results-Systolic and diastolic blood and total with H pylori infection. A weak negative association existed between H pylori infection and fibrinogen (mean (SE) difference in fibrinogen between infected and uninfected individuals - 0.09 (0.04) g/l, P = 0.02) and between infection in women and high density lipoprotein (HDL) cholesterol (mean (SE) difference in HDL cholesterol between infected and uninfected individuals - 0.06 (0.02) mmol/l, P 0.006). A potentially important association was demonstrated between H pylori infection and ischaemic heart disease but this did not reach statistical significance (odds ratio (95% confidence interval (CI) 1.51 (0.93 to 2.45), P = 0.1). Social class was associated with ischaemic heart disease independently of cardiovascular risk factors and H pylori infection (odds ratio, manual v non-manual (95% CI) 1.82 (1.14 to 2.91), P = 0.01). Conclusion-H pylori may be independently associated with the development of ischaemic heart disease but if this is so the mechanism by which this effect is exerted is not through increased concentration of plasma fibrinogen. H pylori infection does not explain the social class inequality in ischaemic heart disease which exists independently of known cardiovascular risk factors.
    LanguageEnglish
    Pages497-501
    JournalBritish Heart Journal
    Volume74
    Issue number5
    Publication statusPublished - Nov 1995

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    Helicobacter Infections
    Pylorus
    Helicobacter pylori
    Social Class
    Myocardial Ischemia
    Infection
    Fibrinogen
    HDL Cholesterol
    Cardiovascular Infections
    Odds Ratio
    Confidence Intervals
    Complement Factor H
    Northern Ireland
    General Practitioners
    Enzyme-Linked Immunosorbent Assay
    Myocardial Infarction
    Outcome Assessment (Health Care)
    Antibodies
    Serum

    Cite this

    MURRAY, LJ., BAMFORD, KB., OREILLY, DPJ., MCCRUM, EE., & EVANS, AE. (1995). HELICOBACTER-PYLORI INFECTION - RELATION WITH CARDIOVASCULAR RISK-FACTORS, ISCHEMIC-HEART-DISEASE, AND SOCIAL-CLASS. British Heart Journal, 74(5), 497-501.
    MURRAY, LJ ; BAMFORD, KB ; OREILLY, DPJ ; MCCRUM, EE ; EVANS, AE. / HELICOBACTER-PYLORI INFECTION - RELATION WITH CARDIOVASCULAR RISK-FACTORS, ISCHEMIC-HEART-DISEASE, AND SOCIAL-CLASS. In: British Heart Journal. 1995 ; Vol. 74, No. 5. pp. 497-501.
    @article{69c8f73b52f24081b377159ca1bbf955,
    title = "HELICOBACTER-PYLORI INFECTION - RELATION WITH CARDIOVASCULAR RISK-FACTORS, ISCHEMIC-HEART-DISEASE, AND SOCIAL-CLASS",
    abstract = "Objective-To determine whether Helicobacter pylori infection is associated with the development of ischaemic heart disease and whether such infection can explain the social class inequality in ischaemic heart disease. Design-Cardiovascular risk factor levels, prevalence of ischaemic heart disease (Rose questionnaire angina, and/or a history of myocardial infarction), and serum antibodies to H pylori (enzyme linked immunosorbent assay) were assessed in a cross sectional population based survey. Setting-Belfast and surrounding districts, Northern Ireland. Participants-1182 men and 1198 women aged 25-64 years randomly selected from the Central Services Agency's general practitioner lists. Main outcome measures-The relation of H pylori infection with cardiovascular risk factors and ischaemic heart disease. The association of social class with ischaemic heart disease. Results-Systolic and diastolic blood and total with H pylori infection. A weak negative association existed between H pylori infection and fibrinogen (mean (SE) difference in fibrinogen between infected and uninfected individuals - 0.09 (0.04) g/l, P = 0.02) and between infection in women and high density lipoprotein (HDL) cholesterol (mean (SE) difference in HDL cholesterol between infected and uninfected individuals - 0.06 (0.02) mmol/l, P 0.006). A potentially important association was demonstrated between H pylori infection and ischaemic heart disease but this did not reach statistical significance (odds ratio (95{\%} confidence interval (CI) 1.51 (0.93 to 2.45), P = 0.1). Social class was associated with ischaemic heart disease independently of cardiovascular risk factors and H pylori infection (odds ratio, manual v non-manual (95{\%} CI) 1.82 (1.14 to 2.91), P = 0.01). Conclusion-H pylori may be independently associated with the development of ischaemic heart disease but if this is so the mechanism by which this effect is exerted is not through increased concentration of plasma fibrinogen. H pylori infection does not explain the social class inequality in ischaemic heart disease which exists independently of known cardiovascular risk factors.",
    author = "LJ MURRAY and KB BAMFORD and DPJ OREILLY and EE MCCRUM and AE EVANS",
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    MURRAY, LJ, BAMFORD, KB, OREILLY, DPJ, MCCRUM, EE & EVANS, AE 1995, 'HELICOBACTER-PYLORI INFECTION - RELATION WITH CARDIOVASCULAR RISK-FACTORS, ISCHEMIC-HEART-DISEASE, AND SOCIAL-CLASS', British Heart Journal, vol. 74, no. 5, pp. 497-501.

    HELICOBACTER-PYLORI INFECTION - RELATION WITH CARDIOVASCULAR RISK-FACTORS, ISCHEMIC-HEART-DISEASE, AND SOCIAL-CLASS. / MURRAY, LJ; BAMFORD, KB; OREILLY, DPJ; MCCRUM, EE; EVANS, AE.

    In: British Heart Journal, Vol. 74, No. 5, 11.1995, p. 497-501.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - HELICOBACTER-PYLORI INFECTION - RELATION WITH CARDIOVASCULAR RISK-FACTORS, ISCHEMIC-HEART-DISEASE, AND SOCIAL-CLASS

    AU - MURRAY, LJ

    AU - BAMFORD, KB

    AU - OREILLY, DPJ

    AU - MCCRUM, EE

    AU - EVANS, AE

    PY - 1995/11

    Y1 - 1995/11

    N2 - Objective-To determine whether Helicobacter pylori infection is associated with the development of ischaemic heart disease and whether such infection can explain the social class inequality in ischaemic heart disease. Design-Cardiovascular risk factor levels, prevalence of ischaemic heart disease (Rose questionnaire angina, and/or a history of myocardial infarction), and serum antibodies to H pylori (enzyme linked immunosorbent assay) were assessed in a cross sectional population based survey. Setting-Belfast and surrounding districts, Northern Ireland. Participants-1182 men and 1198 women aged 25-64 years randomly selected from the Central Services Agency's general practitioner lists. Main outcome measures-The relation of H pylori infection with cardiovascular risk factors and ischaemic heart disease. The association of social class with ischaemic heart disease. Results-Systolic and diastolic blood and total with H pylori infection. A weak negative association existed between H pylori infection and fibrinogen (mean (SE) difference in fibrinogen between infected and uninfected individuals - 0.09 (0.04) g/l, P = 0.02) and between infection in women and high density lipoprotein (HDL) cholesterol (mean (SE) difference in HDL cholesterol between infected and uninfected individuals - 0.06 (0.02) mmol/l, P 0.006). A potentially important association was demonstrated between H pylori infection and ischaemic heart disease but this did not reach statistical significance (odds ratio (95% confidence interval (CI) 1.51 (0.93 to 2.45), P = 0.1). Social class was associated with ischaemic heart disease independently of cardiovascular risk factors and H pylori infection (odds ratio, manual v non-manual (95% CI) 1.82 (1.14 to 2.91), P = 0.01). Conclusion-H pylori may be independently associated with the development of ischaemic heart disease but if this is so the mechanism by which this effect is exerted is not through increased concentration of plasma fibrinogen. H pylori infection does not explain the social class inequality in ischaemic heart disease which exists independently of known cardiovascular risk factors.

    AB - Objective-To determine whether Helicobacter pylori infection is associated with the development of ischaemic heart disease and whether such infection can explain the social class inequality in ischaemic heart disease. Design-Cardiovascular risk factor levels, prevalence of ischaemic heart disease (Rose questionnaire angina, and/or a history of myocardial infarction), and serum antibodies to H pylori (enzyme linked immunosorbent assay) were assessed in a cross sectional population based survey. Setting-Belfast and surrounding districts, Northern Ireland. Participants-1182 men and 1198 women aged 25-64 years randomly selected from the Central Services Agency's general practitioner lists. Main outcome measures-The relation of H pylori infection with cardiovascular risk factors and ischaemic heart disease. The association of social class with ischaemic heart disease. Results-Systolic and diastolic blood and total with H pylori infection. A weak negative association existed between H pylori infection and fibrinogen (mean (SE) difference in fibrinogen between infected and uninfected individuals - 0.09 (0.04) g/l, P = 0.02) and between infection in women and high density lipoprotein (HDL) cholesterol (mean (SE) difference in HDL cholesterol between infected and uninfected individuals - 0.06 (0.02) mmol/l, P 0.006). A potentially important association was demonstrated between H pylori infection and ischaemic heart disease but this did not reach statistical significance (odds ratio (95% confidence interval (CI) 1.51 (0.93 to 2.45), P = 0.1). Social class was associated with ischaemic heart disease independently of cardiovascular risk factors and H pylori infection (odds ratio, manual v non-manual (95% CI) 1.82 (1.14 to 2.91), P = 0.01). Conclusion-H pylori may be independently associated with the development of ischaemic heart disease but if this is so the mechanism by which this effect is exerted is not through increased concentration of plasma fibrinogen. H pylori infection does not explain the social class inequality in ischaemic heart disease which exists independently of known cardiovascular risk factors.

    M3 - Article

    VL - 74

    SP - 497

    EP - 501

    JO - British Heart Journal

    T2 - British Heart Journal

    JF - British Heart Journal

    SN - 0007-0769

    IS - 5

    ER -