HED (Hypohidrotic Ectodermal Dysplasia): A Review

Michele Callea, Francisco Cammarata Scalisi, Izzet Yavuz, Mehmet Sinan Dogan, Colin Eric Willoughby, Murali Dharan Bashyam

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Abstract The ectodermal dysplasias (EDs) are a heterogeneous group of inherited, developmental disorders characterized by alterations in two or more ectodermal structures including the hair, teeth, nails and sweat glands. Currently, more than 200 types of ectodermal dysplasias have been described. Anhidrotic or hypohidrotic ectodermal dysplasia (AED/HED), the most common ED, is characterized by three cardinal features: hypotrichosis, hypohidrosis and hypodontia. We review the genetic and pathogenetic mechanisms of AED/HED and report on the management of clinical manifestations driven by embryology, anatomy and physiology.

    Original languageEnglish
    Pages (from-to)785-789
    Number of pages5
    JournalJournal of International Dental and Medical Research
    Volume14
    Issue number2
    Publication statusPublished - 30 Apr 2021

    Keywords

    • Anhidrotic or hypohidrotic ectodermal dysplasia
    • clinical
    • Ectodermal dysplasias
    • ethiopathogenesis

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