Hall’s Effect Based Sensing Mechanism for Nano Super Paramagnetic Particle-Protein Complex Structure

Danny Wen Yaw Chung; Nikhil Bhalla; Hsi-Wen Li; Yi Ying Ye; Hao Chun Yang; Dorota G. Pijanowska

doi:10.13140/2.1.3415.7449

Hall’s Effect Based Sensing Mechanism for Nano Super Paramagnetic Particle-Protein Complex Structure

Danny Wen Yaw Chung, Nikhil Bhalla, Hsi-Wen Li, Yi Ying Ye, Hao Chun Yang, Dorota G. Pijanowska

Research output: Contribution to conference › Paper › peer-review

Abstract

In this work sensing mechanism for nanomagnetic particles (nano size magnetic beads) bounded with protein complex has been studied. The methodology employed involves formation of antibody-protein complex, similar to the one formed in sandwiched ELISA (Enzyme Linked Immunosorbent Assay), which is bounded to super paramagnetic particle instead of enzyme to detect the presence of protein molecule. Hall's sensor was fabricated using 0.35 m BioMEMS TSMC technology which senses the magnetic field from the beads. The investigation covers Hall's effect simulations, magneto static analysis of forces on nano magnetic beads, mechanical modeling of bead-protein complex and discussion on fabrication of Hall's Sensor. The design also shows the inductive coil on the top the Hall's sensor that is used to magnetize the beads.

Original language	English
DOIs	https://doi.org/10.13140/2.1.3415.7449
Publication status	Published (in print/issue) - Jul 2012
Event	IEEE-Asia Pacific Conference on Transducers APCOT - Nanjing, China Duration: 10 Jul 2012 → …

Conference

Conference	IEEE-Asia Pacific Conference on Transducers APCOT
Country/Territory	China
City	Nanjing
Period	10/07/12 → …

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title = "Hall{\textquoteright}s Effect Based Sensing Mechanism for Nano Super Paramagnetic Particle-Protein Complex Structure",

abstract = "In this work sensing mechanism for nanomagnetic particles (nano size magnetic beads) bounded with protein complex has been studied. The methodology employed involves formation of antibody-protein complex, similar to the one formed in sandwiched ELISA (Enzyme Linked Immunosorbent Assay), which is bounded to super paramagnetic particle instead of enzyme to detect the presence of protein molecule. Hall's sensor was fabricated using 0.35 m BioMEMS TSMC technology which senses the magnetic field from the beads. The investigation covers Hall's effect simulations, magneto static analysis of forces on nano magnetic beads, mechanical modeling of bead-protein complex and discussion on fabrication of Hall's Sensor. The design also shows the inductive coil on the top the Hall's sensor that is used to magnetize the beads.",

author = "Chung, {Danny Wen Yaw} and Nikhil Bhalla and Hsi-Wen Li and Ye, {Yi Ying} and Yang, {Hao Chun} and Pijanowska, {Dorota G.}",

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T1 - Hall’s Effect Based Sensing Mechanism for Nano Super Paramagnetic Particle-Protein Complex Structure

AU - Chung, Danny Wen Yaw

AU - Bhalla, Nikhil

AU - Li, Hsi-Wen

AU - Ye, Yi Ying

AU - Yang, Hao Chun

AU - Pijanowska, Dorota G.

PY - 2012/7

Y1 - 2012/7

N2 - In this work sensing mechanism for nanomagnetic particles (nano size magnetic beads) bounded with protein complex has been studied. The methodology employed involves formation of antibody-protein complex, similar to the one formed in sandwiched ELISA (Enzyme Linked Immunosorbent Assay), which is bounded to super paramagnetic particle instead of enzyme to detect the presence of protein molecule. Hall's sensor was fabricated using 0.35 m BioMEMS TSMC technology which senses the magnetic field from the beads. The investigation covers Hall's effect simulations, magneto static analysis of forces on nano magnetic beads, mechanical modeling of bead-protein complex and discussion on fabrication of Hall's Sensor. The design also shows the inductive coil on the top the Hall's sensor that is used to magnetize the beads.

AB - In this work sensing mechanism for nanomagnetic particles (nano size magnetic beads) bounded with protein complex has been studied. The methodology employed involves formation of antibody-protein complex, similar to the one formed in sandwiched ELISA (Enzyme Linked Immunosorbent Assay), which is bounded to super paramagnetic particle instead of enzyme to detect the presence of protein molecule. Hall's sensor was fabricated using 0.35 m BioMEMS TSMC technology which senses the magnetic field from the beads. The investigation covers Hall's effect simulations, magneto static analysis of forces on nano magnetic beads, mechanical modeling of bead-protein complex and discussion on fabrication of Hall's Sensor. The design also shows the inductive coil on the top the Hall's sensor that is used to magnetize the beads.

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DO - 10.13140/2.1.3415.7449

M3 - Paper

T2 - IEEE-Asia Pacific Conference on Transducers APCOT

Y2 - 10 July 2012

ER -

Hall’s Effect Based Sensing Mechanism for Nano Super Paramagnetic Particle-Protein Complex Structure

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