Habituation to sub-lethal concentrations of tea tree oil (Melaleuca alternifolia) is associated with reduced susceptibility to antibiotics in human pathogens

MAS McMahon, Ian S. Blair, John E. Moore, DA McDowell

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    Objectives: To investigate the effect of sub-lethal challenge with tea tree oil (TTO) on the antibiotic susceptibility profiles of significant human pathogens and commensals. Methods: The study compared the antibiotic susceptibility (Etest) patterns of Escherichia coli, Staphylococcus aureus/methicillin-resistant S. aureus (MRSA) and Salmonella spp. after broth culture for 72 h in the presence or absence of sub-lethal concentrations of TTO (0.25%, 0.25% and 0.1%). Results: All habituated cultures (exposed to sub-lethal concentrations of TTO) displayed reduced susceptibility to a range of clinically relevant antibiotics compared with non-habituated (control) cultures. Conclusions: Although TTO may be an effective antimicrobial agent when appropriately used at bactericidal concentrations, its application at sub-lethal concentrations may contribute to the development of antibiotic resistance in human pathogens.
    LanguageEnglish
    Pages125-127
    JournalJournal of Antimicrobial Chemotherapy
    Volume59
    Issue number1
    DOIs
    Publication statusPublished - Jan 2007

    Fingerprint

    Melaleuca
    Tea Tree Oil
    Anti-Bacterial Agents
    Disk Diffusion Antimicrobial Tests
    Methicillin-Resistant Staphylococcus aureus
    Microbial Drug Resistance
    Anti-Infective Agents
    Salmonella
    Staphylococcus aureus
    Escherichia coli

    Keywords

    • antibiotic susceptibility profiles
    • MRSA
    • antibacterial agents

    Cite this

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    title = "Habituation to sub-lethal concentrations of tea tree oil (Melaleuca alternifolia) is associated with reduced susceptibility to antibiotics in human pathogens",
    abstract = "Objectives: To investigate the effect of sub-lethal challenge with tea tree oil (TTO) on the antibiotic susceptibility profiles of significant human pathogens and commensals. Methods: The study compared the antibiotic susceptibility (Etest) patterns of Escherichia coli, Staphylococcus aureus/methicillin-resistant S. aureus (MRSA) and Salmonella spp. after broth culture for 72 h in the presence or absence of sub-lethal concentrations of TTO (0.25{\%}, 0.25{\%} and 0.1{\%}). Results: All habituated cultures (exposed to sub-lethal concentrations of TTO) displayed reduced susceptibility to a range of clinically relevant antibiotics compared with non-habituated (control) cultures. Conclusions: Although TTO may be an effective antimicrobial agent when appropriately used at bactericidal concentrations, its application at sub-lethal concentrations may contribute to the development of antibiotic resistance in human pathogens.",
    keywords = "antibiotic susceptibility profiles, MRSA, antibacterial agents",
    author = "MAS McMahon and Blair, {Ian S.} and Moore, {John E.} and DA McDowell",
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    Habituation to sub-lethal concentrations of tea tree oil (Melaleuca alternifolia) is associated with reduced susceptibility to antibiotics in human pathogens. / McMahon, MAS; Blair, Ian S.; Moore, John E.; McDowell, DA.

    In: Journal of Antimicrobial Chemotherapy, Vol. 59, No. 1, 01.2007, p. 125-127.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Habituation to sub-lethal concentrations of tea tree oil (Melaleuca alternifolia) is associated with reduced susceptibility to antibiotics in human pathogens

    AU - McMahon, MAS

    AU - Blair, Ian S.

    AU - Moore, John E.

    AU - McDowell, DA

    PY - 2007/1

    Y1 - 2007/1

    N2 - Objectives: To investigate the effect of sub-lethal challenge with tea tree oil (TTO) on the antibiotic susceptibility profiles of significant human pathogens and commensals. Methods: The study compared the antibiotic susceptibility (Etest) patterns of Escherichia coli, Staphylococcus aureus/methicillin-resistant S. aureus (MRSA) and Salmonella spp. after broth culture for 72 h in the presence or absence of sub-lethal concentrations of TTO (0.25%, 0.25% and 0.1%). Results: All habituated cultures (exposed to sub-lethal concentrations of TTO) displayed reduced susceptibility to a range of clinically relevant antibiotics compared with non-habituated (control) cultures. Conclusions: Although TTO may be an effective antimicrobial agent when appropriately used at bactericidal concentrations, its application at sub-lethal concentrations may contribute to the development of antibiotic resistance in human pathogens.

    AB - Objectives: To investigate the effect of sub-lethal challenge with tea tree oil (TTO) on the antibiotic susceptibility profiles of significant human pathogens and commensals. Methods: The study compared the antibiotic susceptibility (Etest) patterns of Escherichia coli, Staphylococcus aureus/methicillin-resistant S. aureus (MRSA) and Salmonella spp. after broth culture for 72 h in the presence or absence of sub-lethal concentrations of TTO (0.25%, 0.25% and 0.1%). Results: All habituated cultures (exposed to sub-lethal concentrations of TTO) displayed reduced susceptibility to a range of clinically relevant antibiotics compared with non-habituated (control) cultures. Conclusions: Although TTO may be an effective antimicrobial agent when appropriately used at bactericidal concentrations, its application at sub-lethal concentrations may contribute to the development of antibiotic resistance in human pathogens.

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