Gut microbiota composition correlates with diet and health in the elderly

Marcus J Claesson; Ian B Jeffery; Susana Conde; Susan E Power; Eibhlis M O' Connor; Siobhan Cusack; Hugh M B Harris; Mairead Coakley; Bhuvaneswari Lakshminarayanan; Orla O' Sullivan; Gerald F Fitzgerald; Jennifer Deane; Michael O' Connor; Norma Harnedy; Kieran O' Connor; Denis O' Mahony; Douwe van Sinderen; Martina Wallace; Lorraine Brennan; Catherine Stanton; Julian R Marchesi; Anthony P Fitzgerald; Fergus Shanahan; Colin Hill; R Paul Ross; Paul W O' Toole

doi:10.1038/nature11319

Gut microbiota composition correlates with diet and health in the elderly

Marcus J Claesson, Ian B Jeffery, Susana Conde, Susan E Power, Eibhlis M O' Connor, Siobhan Cusack, Hugh M B Harris, Mairead Coakley, Bhuvaneswari Lakshminarayanan, Orla O' Sullivan, Gerald F Fitzgerald, Jennifer Deane, Michael O' Connor, Norma Harnedy, Kieran O' Connor, Denis O' Mahony, Douwe van Sinderen, Martina Wallace, Lorraine Brennan, Catherine StantonJulian R Marchesi, Anthony P Fitzgerald, Fergus Shanahan, Colin Hill, R Paul Ross, Paul W O' Toole

Faculty Of Life & Health Sciences

Research output: Contribution to journal › Article › peer-review

2538 Citations (Scopus)

Abstract

Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clusteringof subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty.Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.

Original language	English
Journal	Nature
Volume	488
DOIs	https://doi.org/10.1038/nature11319
Publication status	Accepted/In press - 9 Aug 2012

Keywords

Gut microbiota
Elderly

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nature11319

https://www.nature.com/articles/nature11319.pdf

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Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O' Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O' Sullivan, O., Fitzgerald, G. F., Deane, J., O' Connor, M., Harnedy, N., O' Connor, K., O' Mahony, D., van Sinderen, D., Wallace, M., Brennan, L., ... O' Toole, P. W. (Accepted/In press). Gut microbiota composition correlates with diet and health in the elderly. Nature, 488. https://doi.org/10.1038/nature11319

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title = "Gut microbiota composition correlates with diet and health in the elderly",

abstract = "Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clusteringof subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty.Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.",

keywords = "Gut microbiota, Elderly",

author = "Claesson, {Marcus J} and Jeffery, {Ian B} and Susana Conde and Power, {Susan E} and {O' Connor}, {Eibhlis M} and Siobhan Cusack and Harris, {Hugh M B} and Mairead Coakley and Bhuvaneswari Lakshminarayanan and {O' Sullivan}, Orla and Fitzgerald, {Gerald F} and Jennifer Deane and {O' Connor}, Michael and Norma Harnedy and {O' Connor}, Kieran and {O' Mahony}, Denis and {van Sinderen}, Douwe and Martina Wallace and Lorraine Brennan and Catherine Stanton and Marchesi, {Julian R} and Fitzgerald, {Anthony P} and Fergus Shanahan and Colin Hill and Ross, {R Paul} and {O' Toole}, {Paul W}",

year = "2012",

month = aug,

day = "9",

doi = "10.1038/nature11319",

language = "English",

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Claesson, MJ, Jeffery, IB, Conde, S, Power, SE, O' Connor, EM, Cusack, S, Harris, HMB, Coakley, M, Lakshminarayanan, B, O' Sullivan, O, Fitzgerald, GF, Deane, J, O' Connor, M, Harnedy, N, O' Connor, K, O' Mahony, D, van Sinderen, D, Wallace, M, Brennan, L, Stanton, C, Marchesi, JR, Fitzgerald, AP, Shanahan, F, Hill, C, Ross, RP & O' Toole, PW 2012, 'Gut microbiota composition correlates with diet and health in the elderly', Nature, vol. 488. https://doi.org/10.1038/nature11319

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T1 - Gut microbiota composition correlates with diet and health in the elderly

AU - Claesson, Marcus J

AU - Jeffery, Ian B

AU - Conde, Susana

AU - Power, Susan E

AU - O' Connor, Eibhlis M

AU - Cusack, Siobhan

AU - Harris, Hugh M B

AU - Coakley, Mairead

AU - Lakshminarayanan, Bhuvaneswari

AU - O' Sullivan, Orla

AU - Fitzgerald, Gerald F

AU - Deane, Jennifer

AU - O' Connor, Michael

AU - Harnedy, Norma

AU - O' Connor, Kieran

AU - O' Mahony, Denis

AU - van Sinderen, Douwe

AU - Wallace, Martina

AU - Brennan, Lorraine

AU - Stanton, Catherine

AU - Marchesi, Julian R

AU - Fitzgerald, Anthony P

AU - Shanahan, Fergus

AU - Hill, Colin

AU - Ross, R Paul

AU - O' Toole, Paul W

PY - 2012/8/9

Y1 - 2012/8/9

N2 - Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clusteringof subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty.Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.

AB - Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clusteringof subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty.Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.

KW - Gut microbiota

KW - Elderly

U2 - 10.1038/nature11319

DO - 10.1038/nature11319

M3 - Article

SN - 1476-4687

VL - 488

JO - Nature

JF - Nature

ER -

Gut microbiota composition correlates with diet and health in the elderly

Abstract

Keywords

UN SDGs

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