Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging

Rebecca J. Hirst; Robert Whelan; Rory Boyle; Annalisa Setti; Silvin Knight; John O'Connor; Wilby Williamson; Jason McMorrow; Andrew J. Fagan; James F. Meaney; Rose Anne Kenny; Céline De Looze; Fiona N. Newell

doi:10.1016/j.neurobiolaging.2020.12.004

Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging

Rebecca J. Hirst, Robert Whelan, Rory Boyle, Annalisa Setti, Silvin Knight, John O'Connor, Wilby Williamson, Jason McMorrow, Andrew J. Fagan, James F. Meaney, Rose Anne Kenny, Céline De Looze, Fiona N. Newell

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Abstract

Multisensory perception might provide an important marker of brain function in aging. However, the cortical structures supporting multisensory perception in aging are poorly understood. In this study, we compared regional gray matter volume in a group of middle-aged (n = 101; 49–64 years) and older (n = 116; 71–87 years) adults from The Irish Longitudinal Study on Aging using voxel-based morphometry. Participants completed a measure of multisensory integration, the sound-induced flash illusion, and were grouped as per their illusion susceptibility. A significant interaction was observed in the right angular gyrus; in the middle-aged group, larger gray matter volume corresponded to stronger illusion perception while in older adults larger gray matter corresponded to less illusion susceptibility. This interaction remained significant even when controlling for a range of demographic, sensory, cognitive, and health variables. These findings show that multisensory integration is associated with specific structural differences in the aging brain and highlight the angular gyrus as a possible “cross-modal hub” associated with age-related change in multisensory perception.

Original language	English
Pages (from-to)	83-90
Number of pages	8
Journal	Neurobiology of Aging
Volume	100
Early online date	25 Dec 2020
DOIs	https://doi.org/10.1016/j.neurobiolaging.2020.12.004
Publication status	Published (in print/issue) - 1 Apr 2021

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

Data Access Statement

The data sets generated during and/or analyzed during the present study are not publicly available due to data protection regulations but are accessible at TILDA on reasonable request.

Keywords

Aging
Audio-visual
Gray matter volume
Multisensory
Sound-Induced Flash illusion
Voxel-based morphometry

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10.1016/j.neurobiolaging.2020.12.004

1-s2.0-S0197458020304139-mainFinal published version, 504 KBLicence: CC BY-NC-ND

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Hirst, R. J., Whelan, R., Boyle, R., Setti, A., Knight, S., O'Connor, J., Williamson, W., McMorrow, J., Fagan, A. J., Meaney, J. F., Kenny, R. A., De Looze, C., & Newell, F. N. (2021). Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging. Neurobiology of Aging, 100, 83-90. https://doi.org/10.1016/j.neurobiolaging.2020.12.004

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title = "Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging",

abstract = "Multisensory perception might provide an important marker of brain function in aging. However, the cortical structures supporting multisensory perception in aging are poorly understood. In this study, we compared regional gray matter volume in a group of middle-aged (n = 101; 49–64 years) and older (n = 116; 71–87 years) adults from The Irish Longitudinal Study on Aging using voxel-based morphometry. Participants completed a measure of multisensory integration, the sound-induced flash illusion, and were grouped as per their illusion susceptibility. A significant interaction was observed in the right angular gyrus; in the middle-aged group, larger gray matter volume corresponded to stronger illusion perception while in older adults larger gray matter corresponded to less illusion susceptibility. This interaction remained significant even when controlling for a range of demographic, sensory, cognitive, and health variables. These findings show that multisensory integration is associated with specific structural differences in the aging brain and highlight the angular gyrus as a possible “cross-modal hub” associated with age-related change in multisensory perception.",

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doi = "10.1016/j.neurobiolaging.2020.12.004",

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Hirst, RJ, Whelan, R, Boyle, R, Setti, A, Knight, S, O'Connor, J, Williamson, W, McMorrow, J, Fagan, AJ, Meaney, JF, Kenny, RA, De Looze, C & Newell, FN 2021, 'Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging', Neurobiology of Aging, vol. 100, pp. 83-90. https://doi.org/10.1016/j.neurobiolaging.2020.12.004

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AU - Whelan, Robert

AU - Boyle, Rory

AU - Setti, Annalisa

AU - Knight, Silvin

AU - O'Connor, John

AU - Williamson, Wilby

AU - McMorrow, Jason

AU - Fagan, Andrew J.

AU - Meaney, James F.

AU - Kenny, Rose Anne

AU - De Looze, Céline

AU - Newell, Fiona N.

PY - 2021/4/1

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N2 - Multisensory perception might provide an important marker of brain function in aging. However, the cortical structures supporting multisensory perception in aging are poorly understood. In this study, we compared regional gray matter volume in a group of middle-aged (n = 101; 49–64 years) and older (n = 116; 71–87 years) adults from The Irish Longitudinal Study on Aging using voxel-based morphometry. Participants completed a measure of multisensory integration, the sound-induced flash illusion, and were grouped as per their illusion susceptibility. A significant interaction was observed in the right angular gyrus; in the middle-aged group, larger gray matter volume corresponded to stronger illusion perception while in older adults larger gray matter corresponded to less illusion susceptibility. This interaction remained significant even when controlling for a range of demographic, sensory, cognitive, and health variables. These findings show that multisensory integration is associated with specific structural differences in the aging brain and highlight the angular gyrus as a possible “cross-modal hub” associated with age-related change in multisensory perception.

AB - Multisensory perception might provide an important marker of brain function in aging. However, the cortical structures supporting multisensory perception in aging are poorly understood. In this study, we compared regional gray matter volume in a group of middle-aged (n = 101; 49–64 years) and older (n = 116; 71–87 years) adults from The Irish Longitudinal Study on Aging using voxel-based morphometry. Participants completed a measure of multisensory integration, the sound-induced flash illusion, and were grouped as per their illusion susceptibility. A significant interaction was observed in the right angular gyrus; in the middle-aged group, larger gray matter volume corresponded to stronger illusion perception while in older adults larger gray matter corresponded to less illusion susceptibility. This interaction remained significant even when controlling for a range of demographic, sensory, cognitive, and health variables. These findings show that multisensory integration is associated with specific structural differences in the aging brain and highlight the angular gyrus as a possible “cross-modal hub” associated with age-related change in multisensory perception.

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KW - Audio-visual

KW - Gray matter volume

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KW - Sound-Induced Flash illusion

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ER -

Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging

Abstract

Bibliographical note

Data Access Statement

Keywords

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