Granisetron attenuates exercise-induced conditioned taste aversion in the rat

S Eccles; Eun-Mee Kim; E O'Hare

doi:10.1016/j.appet.2005.02.001

Granisetron attenuates exercise-induced conditioned taste aversion in the rat

S Eccles, Eun-Mee Kim, E O'Hare

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A conditioned taste aversion (CTA) paradigm was used in the present study to investigate whether CTA produced by exercise could be attenuated by the 5-HT3 receptor antagonist granisetron. Male Sprague-Dawley rats were randomly allocated to one of four groups (Ns = 6) and were exposed to salty (0.128 M sodium chloride) or sour (0.00138 M citric acid) solutions. Subjects were injected with either saline solution (1.0 ml, 0.9 %) or granisetron (0.5 mg/kg, IP) and were exposed to 30 min of forced wheel running exercise (70 revolutions/30 min) 10 min after injection. Exercise induced CTA to both the salty (3.7 ml intake) and sour-flaroured (3.1 ml intake) solutions as compared with no exercise (intake 14.0 and 13.7 ml), and administration of granisetron significantly attenuated the exercise-induced CTA to the salty- and sour-flavoured solutions. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	325-328
Journal	Appetite
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/j.appet.2005.02.001
Publication status	Published (in print/issue) - Jun 2005

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title = "Granisetron attenuates exercise-induced conditioned taste aversion in the rat",

abstract = "A conditioned taste aversion (CTA) paradigm was used in the present study to investigate whether CTA produced by exercise could be attenuated by the 5-HT3 receptor antagonist granisetron. Male Sprague-Dawley rats were randomly allocated to one of four groups (Ns = 6) and were exposed to salty (0.128 M sodium chloride) or sour (0.00138 M citric acid) solutions. Subjects were injected with either saline solution (1.0 ml, 0.9 %) or granisetron (0.5 mg/kg, IP) and were exposed to 30 min of forced wheel running exercise (70 revolutions/30 min) 10 min after injection. Exercise induced CTA to both the salty (3.7 ml intake) and sour-flaroured (3.1 ml intake) solutions as compared with no exercise (intake 14.0 and 13.7 ml), and administration of granisetron significantly attenuated the exercise-induced CTA to the salty- and sour-flavoured solutions. (c) 2005 Elsevier Ltd. All rights reserved.",

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T1 - Granisetron attenuates exercise-induced conditioned taste aversion in the rat

AU - Eccles, S

AU - Kim, Eun-Mee

AU - O'Hare, E

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N2 - A conditioned taste aversion (CTA) paradigm was used in the present study to investigate whether CTA produced by exercise could be attenuated by the 5-HT3 receptor antagonist granisetron. Male Sprague-Dawley rats were randomly allocated to one of four groups (Ns = 6) and were exposed to salty (0.128 M sodium chloride) or sour (0.00138 M citric acid) solutions. Subjects were injected with either saline solution (1.0 ml, 0.9 %) or granisetron (0.5 mg/kg, IP) and were exposed to 30 min of forced wheel running exercise (70 revolutions/30 min) 10 min after injection. Exercise induced CTA to both the salty (3.7 ml intake) and sour-flaroured (3.1 ml intake) solutions as compared with no exercise (intake 14.0 and 13.7 ml), and administration of granisetron significantly attenuated the exercise-induced CTA to the salty- and sour-flavoured solutions. (c) 2005 Elsevier Ltd. All rights reserved.

AB - A conditioned taste aversion (CTA) paradigm was used in the present study to investigate whether CTA produced by exercise could be attenuated by the 5-HT3 receptor antagonist granisetron. Male Sprague-Dawley rats were randomly allocated to one of four groups (Ns = 6) and were exposed to salty (0.128 M sodium chloride) or sour (0.00138 M citric acid) solutions. Subjects were injected with either saline solution (1.0 ml, 0.9 %) or granisetron (0.5 mg/kg, IP) and were exposed to 30 min of forced wheel running exercise (70 revolutions/30 min) 10 min after injection. Exercise induced CTA to both the salty (3.7 ml intake) and sour-flaroured (3.1 ml intake) solutions as compared with no exercise (intake 14.0 and 13.7 ml), and administration of granisetron significantly attenuated the exercise-induced CTA to the salty- and sour-flavoured solutions. (c) 2005 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.appet.2005.02.001

DO - 10.1016/j.appet.2005.02.001

M3 - Article

SN - 0195-6663

VL - 44

SP - 325

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JO - Appetite

JF - Appetite

IS - 3

ER -

Granisetron attenuates exercise-induced conditioned taste aversion in the rat

Abstract

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