Granisetron attenuates exercise-induced conditioned taste aversion in the rat

S Eccles, Eun-Mee Kim, E O'Hare

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A conditioned taste aversion (CTA) paradigm was used in the present study to investigate whether CTA produced by exercise could be attenuated by the 5-HT3 receptor antagonist granisetron. Male Sprague-Dawley rats were randomly allocated to one of four groups (Ns = 6) and were exposed to salty (0.128 M sodium chloride) or sour (0.00138 M citric acid) solutions. Subjects were injected with either saline solution (1.0 ml, 0.9 %) or granisetron (0.5 mg/kg, IP) and were exposed to 30 min of forced wheel running exercise (70 revolutions/30 min) 10 min after injection. Exercise induced CTA to both the salty (3.7 ml intake) and sour-flaroured (3.1 ml intake) solutions as compared with no exercise (intake 14.0 and 13.7 ml), and administration of granisetron significantly attenuated the exercise-induced CTA to the salty- and sour-flavoured solutions. (c) 2005 Elsevier Ltd. All rights reserved.
LanguageEnglish
Pages325-328
JournalAppetite
Volume44
Issue number3
DOIs
Publication statusPublished - Jun 2005

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Granisetron
Sodium Chloride
Serotonin 5-HT3 Receptor Antagonists
Receptors, Serotonin, 5-HT3
Citric Acid
Running
Sprague Dawley Rats
Injections

Cite this

Eccles, S ; Kim, Eun-Mee ; O'Hare, E. / Granisetron attenuates exercise-induced conditioned taste aversion in the rat. In: Appetite. 2005 ; Vol. 44, No. 3. pp. 325-328.
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Granisetron attenuates exercise-induced conditioned taste aversion in the rat. / Eccles, S; Kim, Eun-Mee; O'Hare, E.

In: Appetite, Vol. 44, No. 3, 06.2005, p. 325-328.

Research output: Contribution to journalArticle

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