GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study

Anne-Lise Jouen, Antonio Narzisi, Jean Xavier, Elodie Tilmont, Nicolas Bodeau, Valentina Bono, Nabila Ketem-Premel, Salvatore Anzalone, Koushik Maharatna, Mohamed Chetouani, Filippo Muratori, David Cohen, Silvio Bonfiglio, Fabio Apicella, Federico Sicca, Lucia Billeci, Giovani Pioggia, Federico Cruciani, Cristiano Paggetti, Angele GiulianoMaryrose Francisa, Saptarshi Das, Wasifa Jamal, Leo Galway, Mark Donnelly

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Abstract

BackgroundTo meet the required hours of intensive intervention for treating children with autism spectrum disorder (ASD), we developed an automated serious gaming platform (11 games) to deliver intervention at home (GOLIAH) by mapping the imitation and joint attention (JA) subset of age-adapted stimuli from the Early Start Denver Model (ESDM) intervention. Here, we report the results of a 6-month matched controlled exploratory study.MethodsFrom two specialized clinics, we included 14 children (age range 5–8 years) with ASD and 10 controls matched for gender, age, sites, and treatment as usual (TAU). Participants from the experimental group received in addition to TAU four 30-min sessions with GOLIAH per week at home and one at hospital for 6 months. Statistics were performed using Linear Mixed Models.ResultsChildren and parents participated in 40% of the planned sessions. They were able to use the 11 games, and participants trained with GOLIAH improved time to perform the task in most JA games and imitation scores in most imitation games. GOLIAH intervention did not affect Parental Stress Index scores. At end-point, we found in both groups a significant improvement for Autism Diagnostic Observation Schedule scores, Vineland socialization score, Parental Stress Index total score, and Child Behavior Checklist internalizing, externalizing and total problems. However, we found no significant change for by time × group interaction.ConclusionsDespite the lack of superiority of TAU + GOLIAH versus TAU, the results are interesting both in terms of changes by using the gaming platform and lack of parental stress increase. A large randomized controlled trial with younger participants (who are the core target of ESDM model) is now discussed. This should be facilitated by computing GOLIAH for a web platform.
Original languageEnglish
JournalChild and Adolescent Psychiatry and Mental Health
Volume11
Issue number1
DOIs
Publication statusPublished - 22 Mar 2017

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Autistic Disorder
Libraries
Socialization
Child Behavior
Therapeutics
Checklist
Linear Models
Appointments and Schedules
Randomized Controlled Trials
Parents
Observation

Keywords

  • Autism
  • Intervention
  • Computer gaming

Cite this

Jouen, Anne-Lise ; Narzisi, Antonio ; Xavier, Jean ; Tilmont, Elodie ; Bodeau, Nicolas ; Bono, Valentina ; Ketem-Premel, Nabila ; Anzalone, Salvatore ; Maharatna, Koushik ; Chetouani, Mohamed ; Muratori, Filippo ; Cohen, David ; Bonfiglio, Silvio ; Apicella, Fabio ; Sicca, Federico ; Billeci, Lucia ; Pioggia, Giovani ; Cruciani, Federico ; Paggetti, Cristiano ; Giuliano, Angele ; Francisa, Maryrose ; Das, Saptarshi ; Jamal, Wasifa ; Galway, Leo ; Donnelly, Mark. / GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study. In: Child and Adolescent Psychiatry and Mental Health. 2017 ; Vol. 11, No. 1.
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abstract = "BackgroundTo meet the required hours of intensive intervention for treating children with autism spectrum disorder (ASD), we developed an automated serious gaming platform (11 games) to deliver intervention at home (GOLIAH) by mapping the imitation and joint attention (JA) subset of age-adapted stimuli from the Early Start Denver Model (ESDM) intervention. Here, we report the results of a 6-month matched controlled exploratory study.MethodsFrom two specialized clinics, we included 14 children (age range 5–8 years) with ASD and 10 controls matched for gender, age, sites, and treatment as usual (TAU). Participants from the experimental group received in addition to TAU four 30-min sessions with GOLIAH per week at home and one at hospital for 6 months. Statistics were performed using Linear Mixed Models.ResultsChildren and parents participated in 40{\%} of the planned sessions. They were able to use the 11 games, and participants trained with GOLIAH improved time to perform the task in most JA games and imitation scores in most imitation games. GOLIAH intervention did not affect Parental Stress Index scores. At end-point, we found in both groups a significant improvement for Autism Diagnostic Observation Schedule scores, Vineland socialization score, Parental Stress Index total score, and Child Behavior Checklist internalizing, externalizing and total problems. However, we found no significant change for by time × group interaction.ConclusionsDespite the lack of superiority of TAU + GOLIAH versus TAU, the results are interesting both in terms of changes by using the gaming platform and lack of parental stress increase. A large randomized controlled trial with younger participants (who are the core target of ESDM model) is now discussed. This should be facilitated by computing GOLIAH for a web platform.",
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author = "Anne-Lise Jouen and Antonio Narzisi and Jean Xavier and Elodie Tilmont and Nicolas Bodeau and Valentina Bono and Nabila Ketem-Premel and Salvatore Anzalone and Koushik Maharatna and Mohamed Chetouani and Filippo Muratori and David Cohen and Silvio Bonfiglio and Fabio Apicella and Federico Sicca and Lucia Billeci and Giovani Pioggia and Federico Cruciani and Cristiano Paggetti and Angele Giuliano and Maryrose Francisa and Saptarshi Das and Wasifa Jamal and Leo Galway and Mark Donnelly",
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Jouen, A-L, Narzisi, A, Xavier, J, Tilmont, E, Bodeau, N, Bono, V, Ketem-Premel, N, Anzalone, S, Maharatna, K, Chetouani, M, Muratori, F, Cohen, D, Bonfiglio, S, Apicella, F, Sicca, F, Billeci, L, Pioggia, G, Cruciani, F, Paggetti, C, Giuliano, A, Francisa, M, Das, S, Jamal, W, Galway, L & Donnelly, M 2017, 'GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study', Child and Adolescent Psychiatry and Mental Health, vol. 11, no. 1. https://doi.org/10.1186/s13034-017-0154-7

GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study. / Jouen, Anne-Lise; Narzisi, Antonio; Xavier, Jean; Tilmont, Elodie; Bodeau, Nicolas; Bono, Valentina; Ketem-Premel, Nabila; Anzalone, Salvatore; Maharatna, Koushik; Chetouani, Mohamed; Muratori, Filippo; Cohen, David; Bonfiglio, Silvio; Apicella, Fabio; Sicca, Federico; Billeci, Lucia; Pioggia, Giovani; Cruciani, Federico; Paggetti, Cristiano; Giuliano, Angele; Francisa, Maryrose; Das, Saptarshi; Jamal, Wasifa; Galway, Leo; Donnelly, Mark.

In: Child and Adolescent Psychiatry and Mental Health, Vol. 11, No. 1, 22.03.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study

AU - Jouen, Anne-Lise

AU - Narzisi, Antonio

AU - Xavier, Jean

AU - Tilmont, Elodie

AU - Bodeau, Nicolas

AU - Bono, Valentina

AU - Ketem-Premel, Nabila

AU - Anzalone, Salvatore

AU - Maharatna, Koushik

AU - Chetouani, Mohamed

AU - Muratori, Filippo

AU - Cohen, David

AU - Bonfiglio, Silvio

AU - Apicella, Fabio

AU - Sicca, Federico

AU - Billeci, Lucia

AU - Pioggia, Giovani

AU - Cruciani, Federico

AU - Paggetti, Cristiano

AU - Giuliano, Angele

AU - Francisa, Maryrose

AU - Das, Saptarshi

AU - Jamal, Wasifa

AU - Galway, Leo

AU - Donnelly, Mark

PY - 2017/3/22

Y1 - 2017/3/22

N2 - BackgroundTo meet the required hours of intensive intervention for treating children with autism spectrum disorder (ASD), we developed an automated serious gaming platform (11 games) to deliver intervention at home (GOLIAH) by mapping the imitation and joint attention (JA) subset of age-adapted stimuli from the Early Start Denver Model (ESDM) intervention. Here, we report the results of a 6-month matched controlled exploratory study.MethodsFrom two specialized clinics, we included 14 children (age range 5–8 years) with ASD and 10 controls matched for gender, age, sites, and treatment as usual (TAU). Participants from the experimental group received in addition to TAU four 30-min sessions with GOLIAH per week at home and one at hospital for 6 months. Statistics were performed using Linear Mixed Models.ResultsChildren and parents participated in 40% of the planned sessions. They were able to use the 11 games, and participants trained with GOLIAH improved time to perform the task in most JA games and imitation scores in most imitation games. GOLIAH intervention did not affect Parental Stress Index scores. At end-point, we found in both groups a significant improvement for Autism Diagnostic Observation Schedule scores, Vineland socialization score, Parental Stress Index total score, and Child Behavior Checklist internalizing, externalizing and total problems. However, we found no significant change for by time × group interaction.ConclusionsDespite the lack of superiority of TAU + GOLIAH versus TAU, the results are interesting both in terms of changes by using the gaming platform and lack of parental stress increase. A large randomized controlled trial with younger participants (who are the core target of ESDM model) is now discussed. This should be facilitated by computing GOLIAH for a web platform.

AB - BackgroundTo meet the required hours of intensive intervention for treating children with autism spectrum disorder (ASD), we developed an automated serious gaming platform (11 games) to deliver intervention at home (GOLIAH) by mapping the imitation and joint attention (JA) subset of age-adapted stimuli from the Early Start Denver Model (ESDM) intervention. Here, we report the results of a 6-month matched controlled exploratory study.MethodsFrom two specialized clinics, we included 14 children (age range 5–8 years) with ASD and 10 controls matched for gender, age, sites, and treatment as usual (TAU). Participants from the experimental group received in addition to TAU four 30-min sessions with GOLIAH per week at home and one at hospital for 6 months. Statistics were performed using Linear Mixed Models.ResultsChildren and parents participated in 40% of the planned sessions. They were able to use the 11 games, and participants trained with GOLIAH improved time to perform the task in most JA games and imitation scores in most imitation games. GOLIAH intervention did not affect Parental Stress Index scores. At end-point, we found in both groups a significant improvement for Autism Diagnostic Observation Schedule scores, Vineland socialization score, Parental Stress Index total score, and Child Behavior Checklist internalizing, externalizing and total problems. However, we found no significant change for by time × group interaction.ConclusionsDespite the lack of superiority of TAU + GOLIAH versus TAU, the results are interesting both in terms of changes by using the gaming platform and lack of parental stress increase. A large randomized controlled trial with younger participants (who are the core target of ESDM model) is now discussed. This should be facilitated by computing GOLIAH for a web platform.

KW - Autism

KW - Intervention

KW - Computer gaming

U2 - 10.1186/s13034-017-0154-7

DO - 10.1186/s13034-017-0154-7

M3 - Article

C2 - 28344643

VL - 11

JO - Child and Adolescent Psychiatry and Mental Health

JF - Child and Adolescent Psychiatry and Mental Health

SN - 1753-2000

IS - 1

ER -