Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics

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Abstract

With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.
Original languageEnglish
Pages (from-to)1316-1326
JournalNANOMEDICINE
Volume10
Issue number8
DOIs
Publication statusAccepted/In press - 1 Apr 2015

Keywords

  • nanomedicine
  • gold nanoparticles

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