With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.
- gold nanoparticles
Dixon, D. (Accepted/In press). Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics. NANOMEDICINE, 10(8), 1316-1326. https://doi.org/10.2217/nnm.14.219