Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.
LanguageEnglish
Pages1316-1326
JournalNANOMEDICINE
Volume10
Issue number8
DOIs
Publication statusAccepted/In press - 1 Apr 2015

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Gold
Nanoparticles
Diagnostic Imaging
Antineoplastic Agents
Clinical Trials
Research
Pharmaceutical Preparations
Therapeutics

Keywords

  • nanomedicine
  • gold nanoparticles

Cite this

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abstract = "With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.",
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Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics. / Dixon, D.

In: NANOMEDICINE, Vol. 10, No. 8, 01.04.2015, p. 1316-1326.

Research output: Contribution to journalArticle

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