Going beyond antibiotics: Natural plant extracts as an emergent strategy to combat biofilm-associated infections

Janice Kou, Tan Yu Xin, Paul Mccarron, Gaurav Gupta, Harish Dureja, Saurabh Satija, Meenu Mehta, Hamid A. Bakshi, Murtaza M. Tambuwala, Trudi Collet, Kamal Dua, Dinesh Kumar Chellappan

Research output: Contribution to journalArticle

Abstract

Biofilms are a collective of multiple types of bacteria that develop on a variety of surfaces. Biofilm development results in heightened resistance to antibiotics. Quorum sensing plays an important role in biofilm development as it is one of the common communication mechanisms within cells, which balances and stabilizes the environment, when the amount of bacteria increases. Because of the important implications of the roles biofilms play in infectious diseases, it is crucial to investigate natural antibacterial agents that are able to regulate biofilm formation and development. Various studies have suggested that natural plant products have the potential to suppress bacterial growth and exhibit chemopre-ventive traits in the modulation of biofilm development. In this review, we discuss and collate potential antibiofilm drugs and biological molecules from natural sources, along with their underlying mechanisms of action. In addition, we also discuss the antibiofilm drugs that are currently under clinical trials and highlight their potential future uses.

Original languageEnglish
Pages (from-to)125-136
Number of pages12
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume39
Issue number2
Early online date25 Apr 2020
DOIs
Publication statusE-pub ahead of print - 25 Apr 2020

Keywords

  • Antibiofilm strategies
  • Bacterial infections
  • Drug resistance
  • Medicinal plants
  • Quorum sensing inhibitio

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