Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation

Finbarr O'Harte, MH Mooney, CMN Kelly, Peter Flatt

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Monoglycated cholecystokinin octapeptide (CCK-8) (glucitol-Asp(1) adduct) modified at the NH2-terminus was prepared under hyperglycemic conditions, purified by high-performance liquid chromatography, and characterized by mass spectrometry (M-r 1228.4 Da) and peptide sequencing. CCK-8 (100 nmol/kg, i.p.) significantly (P <0.001) reduced voluntary food intake of fasted mice for up to 30 min after its administration, compared with saline-administered controls. Glycated CCK-8 reduced food intake at 30-120 min (P
LanguageEnglish
Pages1619-1624
JournalDiabetes
Volume47
Issue number10
Publication statusPublished - Oct 1998

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Sincalide
Eating
Sorbitol
Mass Spectrometry
High Pressure Liquid Chromatography
Peptides
cholecystokinin 8

Cite this

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abstract = "Monoglycated cholecystokinin octapeptide (CCK-8) (glucitol-Asp(1) adduct) modified at the NH2-terminus was prepared under hyperglycemic conditions, purified by high-performance liquid chromatography, and characterized by mass spectrometry (M-r 1228.4 Da) and peptide sequencing. CCK-8 (100 nmol/kg, i.p.) significantly (P <0.001) reduced voluntary food intake of fasted mice for up to 30 min after its administration, compared with saline-administered controls. Glycated CCK-8 reduced food intake at 30-120 min (P",
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Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation. / O'Harte, Finbarr; Mooney, MH; Kelly, CMN; Flatt, Peter.

In: Diabetes, Vol. 47, No. 10, 10.1998, p. 1619-1624.

Research output: Contribution to journalArticle

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AU - O'Harte, Finbarr

AU - Mooney, MH

AU - Kelly, CMN

AU - Flatt, Peter

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AB - Monoglycated cholecystokinin octapeptide (CCK-8) (glucitol-Asp(1) adduct) modified at the NH2-terminus was prepared under hyperglycemic conditions, purified by high-performance liquid chromatography, and characterized by mass spectrometry (M-r 1228.4 Da) and peptide sequencing. CCK-8 (100 nmol/kg, i.p.) significantly (P <0.001) reduced voluntary food intake of fasted mice for up to 30 min after its administration, compared with saline-administered controls. Glycated CCK-8 reduced food intake at 30-120 min (P

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T2 - Diabetes

JF - Diabetes

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