Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation

Finbarr O'Harte; MH Mooney; CMN Kelly; Peter Flatt

Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation

Finbarr O'Harte, MH Mooney, CMN Kelly, Peter Flatt

Research output: Contribution to journal › Article › peer-review

Abstract

Monoglycated cholecystokinin octapeptide (CCK-8) (glucitol-Asp(1) adduct) modified at the NH2-terminus was prepared under hyperglycemic conditions, purified by high-performance liquid chromatography, and characterized by mass spectrometry (M-r 1228.4 Da) and peptide sequencing. CCK-8 (100 nmol/kg, i.p.) significantly (P <0.001) reduced voluntary food intake of fasted mice for up to 30 min after its administration, compared with saline-administered controls. Glycated CCK-8 reduced food intake at 30-120 min (P

Original language	English
Pages (from-to)	1619-1624
Journal	Diabetes
Volume	47
Issue number	10
Publication status	Published (in print/issue) - Oct 1998

Cite this

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title = "Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation",

abstract = "Monoglycated cholecystokinin octapeptide (CCK-8) (glucitol-Asp(1) adduct) modified at the NH2-terminus was prepared under hyperglycemic conditions, purified by high-performance liquid chromatography, and characterized by mass spectrometry (M-r 1228.4 Da) and peptide sequencing. CCK-8 (100 nmol/kg, i.p.) significantly (P <0.001) reduced voluntary food intake of fasted mice for up to 30 min after its administration, compared with saline-administered controls. Glycated CCK-8 reduced food intake at 30-120 min (P",

author = "Finbarr O'Harte and MH Mooney and CMN Kelly and Peter Flatt",

year = "1998",

month = oct,

language = "English",

volume = "47",

pages = "1619--1624",

journal = "Diabetes",

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publisher = "American Diabetes Association ",

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T1 - Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation

AU - O'Harte, Finbarr

AU - Mooney, MH

AU - Kelly, CMN

AU - Flatt, Peter

PY - 1998/10

Y1 - 1998/10

N2 - Monoglycated cholecystokinin octapeptide (CCK-8) (glucitol-Asp(1) adduct) modified at the NH2-terminus was prepared under hyperglycemic conditions, purified by high-performance liquid chromatography, and characterized by mass spectrometry (M-r 1228.4 Da) and peptide sequencing. CCK-8 (100 nmol/kg, i.p.) significantly (P <0.001) reduced voluntary food intake of fasted mice for up to 30 min after its administration, compared with saline-administered controls. Glycated CCK-8 reduced food intake at 30-120 min (P

AB - Monoglycated cholecystokinin octapeptide (CCK-8) (glucitol-Asp(1) adduct) modified at the NH2-terminus was prepared under hyperglycemic conditions, purified by high-performance liquid chromatography, and characterized by mass spectrometry (M-r 1228.4 Da) and peptide sequencing. CCK-8 (100 nmol/kg, i.p.) significantly (P <0.001) reduced voluntary food intake of fasted mice for up to 30 min after its administration, compared with saline-administered controls. Glycated CCK-8 reduced food intake at 30-120 min (P

M3 - Article

SN - 1939-327X

VL - 47

SP - 1619

EP - 1624

JO - Diabetes

JF - Diabetes

IS - 10

ER -

Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation

Abstract

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