Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation

Finbarr O'Harte, MH Mooney, CMN Kelly, Peter Flatt

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28 Citations (Scopus)

Abstract

Monoglycated cholecystokinin octapeptide (CCK-8) (glucitol-Asp(1) adduct) modified at the NH2-terminus was prepared under hyperglycemic conditions, purified by high-performance liquid chromatography, and characterized by mass spectrometry (M-r 1228.4 Da) and peptide sequencing. CCK-8 (100 nmol/kg, i.p.) significantly (P <0.001) reduced voluntary food intake of fasted mice for up to 30 min after its administration, compared with saline-administered controls. Glycated CCK-8 reduced food intake at 30-120 min (P
Original languageEnglish
Pages (from-to)1619-1624
JournalDiabetes
Volume47
Issue number10
Publication statusPublished - Oct 1998

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