Abstract
Understanding the control of self-assemblyand stereochemical properties of DNA higher orderACHTUNGTRENUNGarchitectural folds is of fundamental importance in biologyas well as biochemical technological applications.Guanine-rich DNA sequences can form tetrahelicalACHTUNGTRENUNGarchitectures termed quadruplexes. A formalism is presenteddescribing the interdependency of a set of structuraldescriptors as a geometric basis for folding of unimolecularquadruplex topologies. It represents a standardfor interpretation of structural characteristics ofquadruplexes, and is comprehensive in explicitly harmonizingthe results of published literature with a unifiedlanguage. The formalism is a fundamental step towardsprediction of unimolecular quadruplex folding topologiesfrom primary sequence.
Original language | English |
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Journal | Chem. Eur. J. |
Volume | 13 |
DOIs | |
Publication status | Published (in print/issue) - 30 Oct 2007 |