Geometric Formalism for DNA Quadruplex F olding

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Abstract

Understanding the control of self-assemblyand stereochemical properties of DNA higher orderACHTUNGTRENUNGarchitectural folds is of fundamental importance in biologyas well as biochemical technological applications.Guanine-rich DNA sequences can form tetrahelicalACHTUNGTRENUNGarchitectures termed quadruplexes. A formalism is presenteddescribing the interdependency of a set of structuraldescriptors as a geometric basis for folding of unimolecularquadruplex topologies. It represents a standardfor interpretation of structural characteristics ofquadruplexes, and is comprehensive in explicitly harmonizingthe results of published literature with a unifiedlanguage. The formalism is a fundamental step towardsprediction of unimolecular quadruplex folding topologiesfrom primary sequence.
LanguageEnglish
JournalChem. Eur. J.
Volume13
DOIs
Publication statusPublished - 30 Oct 2007

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folding
deoxyribonucleic acid
formalism
guanines
topology

Cite this

@article{27d8be6b4b714539ac64d79370442e6d,
title = "Geometric Formalism for DNA Quadruplex F olding",
abstract = "Understanding the control of self-assemblyand stereochemical properties of DNA higher orderACHTUNGTRENUNGarchitectural folds is of fundamental importance in biologyas well as biochemical technological applications.Guanine-rich DNA sequences can form tetrahelicalACHTUNGTRENUNGarchitectures termed quadruplexes. A formalism is presenteddescribing the interdependency of a set of structuraldescriptors as a geometric basis for folding of unimolecularquadruplex topologies. It represents a standardfor interpretation of structural characteristics ofquadruplexes, and is comprehensive in explicitly harmonizingthe results of published literature with a unifiedlanguage. The formalism is a fundamental step towardsprediction of unimolecular quadruplex folding topologiesfrom primary sequence.",
author = "{Webba da Silva}, Mateus",
year = "2007",
month = "10",
day = "30",
doi = "10.1002/chem.200701255",
language = "English",
volume = "13",
journal = "Chemistry - A European Journal",
issn = "0947-6539",

}

Geometric Formalism for DNA Quadruplex F olding. / Webba da Silva, Mateus.

In: Chem. Eur. J., Vol. 13, 30.10.2007.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Geometric Formalism for DNA Quadruplex F olding

AU - Webba da Silva, Mateus

PY - 2007/10/30

Y1 - 2007/10/30

N2 - Understanding the control of self-assemblyand stereochemical properties of DNA higher orderACHTUNGTRENUNGarchitectural folds is of fundamental importance in biologyas well as biochemical technological applications.Guanine-rich DNA sequences can form tetrahelicalACHTUNGTRENUNGarchitectures termed quadruplexes. A formalism is presenteddescribing the interdependency of a set of structuraldescriptors as a geometric basis for folding of unimolecularquadruplex topologies. It represents a standardfor interpretation of structural characteristics ofquadruplexes, and is comprehensive in explicitly harmonizingthe results of published literature with a unifiedlanguage. The formalism is a fundamental step towardsprediction of unimolecular quadruplex folding topologiesfrom primary sequence.

AB - Understanding the control of self-assemblyand stereochemical properties of DNA higher orderACHTUNGTRENUNGarchitectural folds is of fundamental importance in biologyas well as biochemical technological applications.Guanine-rich DNA sequences can form tetrahelicalACHTUNGTRENUNGarchitectures termed quadruplexes. A formalism is presenteddescribing the interdependency of a set of structuraldescriptors as a geometric basis for folding of unimolecularquadruplex topologies. It represents a standardfor interpretation of structural characteristics ofquadruplexes, and is comprehensive in explicitly harmonizingthe results of published literature with a unifiedlanguage. The formalism is a fundamental step towardsprediction of unimolecular quadruplex folding topologiesfrom primary sequence.

U2 - 10.1002/chem.200701255

DO - 10.1002/chem.200701255

M3 - Article

VL - 13

JO - Chemistry - A European Journal

T2 - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

ER -