Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

J. Deelen, M. Beekman, H.-W. Uh, L. Broer, K.L. Ayers, Q. Tan, Y. Kamatani, A.M. Bennet, R. Tamm, S. Trompet, D.F. Guobjartsson, F. Flachsbart, G. Rose, A. Viktorin, K. Fischer, M. Nygaard, H.J. Cordell, P. Crocco, E.B. Van Den Akker, S. BöhringerQ. Helmer, C.P. Nelson, G.I. Saunders, M. Alver, K. Andersen-Ranberg, M.E. Breen, R. van Der Breggen, A. Caliebe, M. Capri, E. Cevenini, J.C. Collerton, S. Dato, K. Davies, I. Ford, J. Gampe, P. Garagnani, E.J.C. de Geus, J. Harrow, D. Van Heemst, B.T. Heijmans, F.-A. Heinsen, J.-J. Hottenga, A. Hofman, B. Jeune, P.V. Jonsson, M. Lathrop, D. Lechner, C. Martin-Ruiz, S.E. Mcnerlan, E. Mihailov, A. Montesanto, S.P. Mooijaart, A. Murphy, E.A. Nohr, L. Paternoster, I. Postmus, F. Rivadeneira, O.A. Ross, S. Salvioli, N. Sattar, S. Schreiber, H. Stefánsson, D.J. Stott, H. Tiemeier, A.G. Uitterlinden, R.G.J. Westendorp, G. Willemsen, N.J. Samani, P. Galan, T.I.A. Sørensen, D.I. Boomsma, J. Wouter Jukema, I.M. Rea, G. Passarino, A.J.M. de Craen, K. Christensen, A. Nebel, K. Stefánsson, A. Metspalu, P. Magnusson, H. Blanché, L. Christiansen, T.B.L. Kirkwood, C.M. Van Duijn, C. Franceschi, J.J. Houwing-Duistermaat, P.E. Slagboom

    Research output: Contribution to journalArticle

    136 Citations (Scopus)
    Original languageEnglish
    Pages (from-to)4420-4432
    JournalHuman Molecular Genetics
    Volume23
    Issue number16
    DOIs
    Publication statusPublished - 31 Mar 2014

    Keywords

    • EMTREE medical terms: aged
    • allele
    • article
    • blood pressure
    • cardiovascular disease
    • cardiovascular risk
    • cerebrovascular accident
    • chromosome 19q
    • chromosome 5q
    • controlled study
    • coronary artery disease
    • disease predisposition
    • Europe
    • female
    • follow up
    • gene linkage disequilibrium
    • gene locus
    • gene mapping
    • gene replication
    • genetic association
    • heritability
    • human
    • hypotension
    • lifespan
    • longevity
    • major clinical study
    • male
    • phenotype
    • pleiotropy
    • priority journal
    • prospective study
    • single nucleotide polymorphism
    • survival
    • very elderly
    • aging
    • Article
    • cardiovascular mortality
    • European
    • genetic risk
    • genetic variability

    Cite this

    Deelen, J., Beekman, M., Uh, H-W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Guobjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., Van Den Akker, E. B., ... Slagboom, P. E. (2014). Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics, 23(16), 4420-4432. https://doi.org/10.1093/hmg/ddu139