Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

J. Deelen, M. Beekman, H.-W. Uh, L. Broer, K.L. Ayers, Q. Tan, Y. Kamatani, A.M. Bennet, R. Tamm, S. Trompet, D.F. Guobjartsson, F. Flachsbart, G. Rose, A. Viktorin, K. Fischer, M. Nygaard, H.J. Cordell, P. Crocco, E.B. Van Den Akker, S. Böhringer & 67 others Q. Helmer, C.P. Nelson, G.I. Saunders, M. Alver, K. Andersen-Ranberg, M.E. Breen, R. van Der Breggen, A. Caliebe, M. Capri, E. Cevenini, J.C. Collerton, S. Dato, K. Davies, I. Ford, J. Gampe, P. Garagnani, E.J.C. de Geus, J. Harrow, D. Van Heemst, B.T. Heijmans, F.-A. Heinsen, J.-J. Hottenga, A. Hofman, B. Jeune, P.V. Jonsson, M. Lathrop, D. Lechner, C. Martin-Ruiz, S.E. Mcnerlan, E. Mihailov, A. Montesanto, S.P. Mooijaart, A. Murphy, E.A. Nohr, L. Paternoster, I. Postmus, F. Rivadeneira, O.A. Ross, S. Salvioli, N. Sattar, S. Schreiber, H. Stefánsson, D.J. Stott, H. Tiemeier, A.G. Uitterlinden, R.G.J. Westendorp, G. Willemsen, N.J. Samani, P. Galan, T.I.A. Sørensen, D.I. Boomsma, J. Wouter Jukema, I.M. Rea, G. Passarino, A.J.M. de Craen, K. Christensen, A. Nebel, K. Stefánsson, A. Metspalu, P. Magnusson, H. Blanché, L. Christiansen, T.B.L. Kirkwood, C.M. Van Duijn, C. Franceschi, J.J. Houwing-Duistermaat, P.E. Slagboom

    Research output: Contribution to journalArticle

    122 Citations (Scopus)
    LanguageEnglish
    Pages4420-4432
    JournalHuman Molecular Genetics
    Volume23
    Issue number16
    DOIs
    Publication statusPublished - 31 Mar 2014

    Keywords

    • EMTREE medical terms: aged
    • allele
    • article
    • blood pressure
    • cardiovascular disease
    • cardiovascular risk
    • cerebrovascular accident
    • chromosome 19q
    • chromosome 5q
    • controlled study
    • coronary artery disease
    • disease predisposition
    • Europe
    • female
    • follow up
    • gene linkage disequilibrium
    • gene locus
    • gene mapping
    • gene replication
    • genetic association
    • heritability
    • human
    • hypotension
    • lifespan
    • longevity
    • major clinical study
    • male
    • phenotype
    • pleiotropy
    • priority journal
    • prospective study
    • single nucleotide polymorphism
    • survival
    • very elderly
    • aging
    • Article
    • cardiovascular mortality
    • European
    • genetic risk
    • genetic variability

    Cite this

    Deelen, J. ; Beekman, M. ; Uh, H.-W. ; Broer, L. ; Ayers, K.L. ; Tan, Q. ; Kamatani, Y. ; Bennet, A.M. ; Tamm, R. ; Trompet, S. ; Guobjartsson, D.F. ; Flachsbart, F. ; Rose, G. ; Viktorin, A. ; Fischer, K. ; Nygaard, M. ; Cordell, H.J. ; Crocco, P. ; Van Den Akker, E.B. ; Böhringer, S. ; Helmer, Q. ; Nelson, C.P. ; Saunders, G.I. ; Alver, M. ; Andersen-Ranberg, K. ; Breen, M.E. ; van Der Breggen, R. ; Caliebe, A. ; Capri, M. ; Cevenini, E. ; Collerton, J.C. ; Dato, S. ; Davies, K. ; Ford, I. ; Gampe, J. ; Garagnani, P. ; de Geus, E.J.C. ; Harrow, J. ; Van Heemst, D. ; Heijmans, B.T. ; Heinsen, F.-A. ; Hottenga, J.-J. ; Hofman, A. ; Jeune, B. ; Jonsson, P.V. ; Lathrop, M. ; Lechner, D. ; Martin-Ruiz, C. ; Mcnerlan, S.E. ; Mihailov, E. ; Montesanto, A. ; Mooijaart, S.P. ; Murphy, A. ; Nohr, E.A. ; Paternoster, L. ; Postmus, I. ; Rivadeneira, F. ; Ross, O.A. ; Salvioli, S. ; Sattar, N. ; Schreiber, S. ; Stefánsson, H. ; Stott, D.J. ; Tiemeier, H. ; Uitterlinden, A.G. ; Westendorp, R.G.J. ; Willemsen, G. ; Samani, N.J. ; Galan, P. ; Sørensen, T.I.A. ; Boomsma, D.I. ; Wouter Jukema, J. ; Rea, I.M. ; Passarino, G. ; de Craen, A.J.M. ; Christensen, K. ; Nebel, A. ; Stefánsson, K. ; Metspalu, A. ; Magnusson, P. ; Blanché, H. ; Christiansen, L. ; Kirkwood, T.B.L. ; Van Duijn, C.M. ; Franceschi, C. ; Houwing-Duistermaat, J.J. ; Slagboom, P.E. / Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. In: Human Molecular Genetics. 2014 ; Vol. 23, No. 16. pp. 4420-4432.
    @article{01156e0dba98481b80b89537113403ab,
    title = "Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age",
    keywords = "EMTREE medical terms: aged, allele, article, blood pressure, cardiovascular disease, cardiovascular risk, cerebrovascular accident, chromosome 19q, chromosome 5q, controlled study, coronary artery disease, disease predisposition, Europe, female, follow up, gene linkage disequilibrium, gene locus, gene mapping, gene replication, genetic association, heritability, human, hypotension, lifespan, longevity, major clinical study, male, phenotype, pleiotropy, priority journal, prospective study, single nucleotide polymorphism, survival, very elderly, aging, Article, cardiovascular mortality, European, genetic risk, genetic variability",
    author = "J. Deelen and M. Beekman and H.-W. Uh and L. Broer and K.L. Ayers and Q. Tan and Y. Kamatani and A.M. Bennet and R. Tamm and S. Trompet and D.F. Guobjartsson and F. Flachsbart and G. Rose and A. Viktorin and K. Fischer and M. Nygaard and H.J. Cordell and P. Crocco and {Van Den Akker}, E.B. and S. B{\"o}hringer and Q. Helmer and C.P. Nelson and G.I. Saunders and M. Alver and K. Andersen-Ranberg and M.E. Breen and {van Der Breggen}, R. and A. Caliebe and M. Capri and E. Cevenini and J.C. Collerton and S. Dato and K. Davies and I. Ford and J. Gampe and P. Garagnani and {de Geus}, E.J.C. and J. Harrow and {Van Heemst}, D. and B.T. Heijmans and F.-A. Heinsen and J.-J. Hottenga and A. Hofman and B. Jeune and P.V. Jonsson and M. Lathrop and D. Lechner and C. Martin-Ruiz and S.E. Mcnerlan and E. Mihailov and A. Montesanto and S.P. Mooijaart and A. Murphy and E.A. Nohr and L. Paternoster and I. Postmus and F. Rivadeneira and O.A. Ross and S. Salvioli and N. Sattar and S. Schreiber and H. Stef{\'a}nsson and D.J. Stott and H. Tiemeier and A.G. Uitterlinden and R.G.J. Westendorp and G. Willemsen and N.J. Samani and P. Galan and T.I.A. S{\o}rensen and D.I. Boomsma and {Wouter Jukema}, J. and I.M. Rea and G. Passarino and {de Craen}, A.J.M. and K. Christensen and A. Nebel and K. Stef{\'a}nsson and A. Metspalu and P. Magnusson and H. Blanch{\'e} and L. Christiansen and T.B.L. Kirkwood and {Van Duijn}, C.M. and C. Franceschi and J.J. Houwing-Duistermaat and P.E. Slagboom",
    note = "cited By 56",
    year = "2014",
    month = "3",
    day = "31",
    doi = "10.1093/hmg/ddu139",
    language = "English",
    volume = "23",
    pages = "4420--4432",
    journal = "Human Molecular Genetics",
    issn = "0964-6906",
    number = "16",

    }

    Deelen, J, Beekman, M, Uh, H-W, Broer, L, Ayers, KL, Tan, Q, Kamatani, Y, Bennet, AM, Tamm, R, Trompet, S, Guobjartsson, DF, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, HJ, Crocco, P, Van Den Akker, EB, Böhringer, S, Helmer, Q, Nelson, CP, Saunders, GI, Alver, M, Andersen-Ranberg, K, Breen, ME, van Der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, JC, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, EJC, Harrow, J, Van Heemst, D, Heijmans, BT, Heinsen, F-A, Hottenga, J-J, Hofman, A, Jeune, B, Jonsson, PV, Lathrop, M, Lechner, D, Martin-Ruiz, C, Mcnerlan, SE, Mihailov, E, Montesanto, A, Mooijaart, SP, Murphy, A, Nohr, EA, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, OA, Salvioli, S, Sattar, N, Schreiber, S, Stefánsson, H, Stott, DJ, Tiemeier, H, Uitterlinden, AG, Westendorp, RGJ, Willemsen, G, Samani, NJ, Galan, P, Sørensen, TIA, Boomsma, DI, Wouter Jukema, J, Rea, IM, Passarino, G, de Craen, AJM, Christensen, K, Nebel, A, Stefánsson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, TBL, Van Duijn, CM, Franceschi, C, Houwing-Duistermaat, JJ & Slagboom, PE 2014, 'Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age', Human Molecular Genetics, vol. 23, no. 16, pp. 4420-4432. https://doi.org/10.1093/hmg/ddu139

    Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. / Deelen, J.; Beekman, M.; Uh, H.-W.; Broer, L.; Ayers, K.L.; Tan, Q.; Kamatani, Y.; Bennet, A.M.; Tamm, R.; Trompet, S.; Guobjartsson, D.F.; Flachsbart, F.; Rose, G.; Viktorin, A.; Fischer, K.; Nygaard, M.; Cordell, H.J.; Crocco, P.; Van Den Akker, E.B.; Böhringer, S.; Helmer, Q.; Nelson, C.P.; Saunders, G.I.; Alver, M.; Andersen-Ranberg, K.; Breen, M.E.; van Der Breggen, R.; Caliebe, A.; Capri, M.; Cevenini, E.; Collerton, J.C.; Dato, S.; Davies, K.; Ford, I.; Gampe, J.; Garagnani, P.; de Geus, E.J.C.; Harrow, J.; Van Heemst, D.; Heijmans, B.T.; Heinsen, F.-A.; Hottenga, J.-J.; Hofman, A.; Jeune, B.; Jonsson, P.V.; Lathrop, M.; Lechner, D.; Martin-Ruiz, C.; Mcnerlan, S.E.; Mihailov, E.; Montesanto, A.; Mooijaart, S.P.; Murphy, A.; Nohr, E.A.; Paternoster, L.; Postmus, I.; Rivadeneira, F.; Ross, O.A.; Salvioli, S.; Sattar, N.; Schreiber, S.; Stefánsson, H.; Stott, D.J.; Tiemeier, H.; Uitterlinden, A.G.; Westendorp, R.G.J.; Willemsen, G.; Samani, N.J.; Galan, P.; Sørensen, T.I.A.; Boomsma, D.I.; Wouter Jukema, J.; Rea, I.M.; Passarino, G.; de Craen, A.J.M.; Christensen, K.; Nebel, A.; Stefánsson, K.; Metspalu, A.; Magnusson, P.; Blanché, H.; Christiansen, L.; Kirkwood, T.B.L.; Van Duijn, C.M.; Franceschi, C.; Houwing-Duistermaat, J.J.; Slagboom, P.E.

    In: Human Molecular Genetics, Vol. 23, No. 16, 31.03.2014, p. 4420-4432.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

    AU - Deelen, J.

    AU - Beekman, M.

    AU - Uh, H.-W.

    AU - Broer, L.

    AU - Ayers, K.L.

    AU - Tan, Q.

    AU - Kamatani, Y.

    AU - Bennet, A.M.

    AU - Tamm, R.

    AU - Trompet, S.

    AU - Guobjartsson, D.F.

    AU - Flachsbart, F.

    AU - Rose, G.

    AU - Viktorin, A.

    AU - Fischer, K.

    AU - Nygaard, M.

    AU - Cordell, H.J.

    AU - Crocco, P.

    AU - Van Den Akker, E.B.

    AU - Böhringer, S.

    AU - Helmer, Q.

    AU - Nelson, C.P.

    AU - Saunders, G.I.

    AU - Alver, M.

    AU - Andersen-Ranberg, K.

    AU - Breen, M.E.

    AU - van Der Breggen, R.

    AU - Caliebe, A.

    AU - Capri, M.

    AU - Cevenini, E.

    AU - Collerton, J.C.

    AU - Dato, S.

    AU - Davies, K.

    AU - Ford, I.

    AU - Gampe, J.

    AU - Garagnani, P.

    AU - de Geus, E.J.C.

    AU - Harrow, J.

    AU - Van Heemst, D.

    AU - Heijmans, B.T.

    AU - Heinsen, F.-A.

    AU - Hottenga, J.-J.

    AU - Hofman, A.

    AU - Jeune, B.

    AU - Jonsson, P.V.

    AU - Lathrop, M.

    AU - Lechner, D.

    AU - Martin-Ruiz, C.

    AU - Mcnerlan, S.E.

    AU - Mihailov, E.

    AU - Montesanto, A.

    AU - Mooijaart, S.P.

    AU - Murphy, A.

    AU - Nohr, E.A.

    AU - Paternoster, L.

    AU - Postmus, I.

    AU - Rivadeneira, F.

    AU - Ross, O.A.

    AU - Salvioli, S.

    AU - Sattar, N.

    AU - Schreiber, S.

    AU - Stefánsson, H.

    AU - Stott, D.J.

    AU - Tiemeier, H.

    AU - Uitterlinden, A.G.

    AU - Westendorp, R.G.J.

    AU - Willemsen, G.

    AU - Samani, N.J.

    AU - Galan, P.

    AU - Sørensen, T.I.A.

    AU - Boomsma, D.I.

    AU - Wouter Jukema, J.

    AU - Rea, I.M.

    AU - Passarino, G.

    AU - de Craen, A.J.M.

    AU - Christensen, K.

    AU - Nebel, A.

    AU - Stefánsson, K.

    AU - Metspalu, A.

    AU - Magnusson, P.

    AU - Blanché, H.

    AU - Christiansen, L.

    AU - Kirkwood, T.B.L.

    AU - Van Duijn, C.M.

    AU - Franceschi, C.

    AU - Houwing-Duistermaat, J.J.

    AU - Slagboom, P.E.

    N1 - cited By 56

    PY - 2014/3/31

    Y1 - 2014/3/31

    KW - EMTREE medical terms: aged

    KW - allele

    KW - article

    KW - blood pressure

    KW - cardiovascular disease

    KW - cardiovascular risk

    KW - cerebrovascular accident

    KW - chromosome 19q

    KW - chromosome 5q

    KW - controlled study

    KW - coronary artery disease

    KW - disease predisposition

    KW - Europe

    KW - female

    KW - follow up

    KW - gene linkage disequilibrium

    KW - gene locus

    KW - gene mapping

    KW - gene replication

    KW - genetic association

    KW - heritability

    KW - human

    KW - hypotension

    KW - lifespan

    KW - longevity

    KW - major clinical study

    KW - male

    KW - phenotype

    KW - pleiotropy

    KW - priority journal

    KW - prospective study

    KW - single nucleotide polymorphism

    KW - survival

    KW - very elderly

    KW - aging

    KW - Article

    KW - cardiovascular mortality

    KW - European

    KW - genetic risk

    KW - genetic variability

    U2 - 10.1093/hmg/ddu139

    DO - 10.1093/hmg/ddu139

    M3 - Article

    VL - 23

    SP - 4420

    EP - 4432

    JO - Human Molecular Genetics

    T2 - Human Molecular Genetics

    JF - Human Molecular Genetics

    SN - 0964-6906

    IS - 16

    ER -