Genetic Polymorphisms and Zinc Status: Implications for Supplementation in Metabolic Diseases

Fabio Virgili, Roberto Ambra, Jacqueline M. McCormack, Liz Simpson, Donatella Ciarapica, Lorenzo Barnaba, Elena Azzini, Angela Polito

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Zinc is an essential component for all living organisms, representing the second most abundant trace element, after iron. This element is widely distributed in the tissues of a human body where it is involved in normal growth, reproduction and several biological functions including immunity, energy metabolism and antioxidant processes. Because of its essential role, zinc levels in the human body must remain constant, independently of dietary intake fluctuations. The homeostasis of zinc is a well-regulated cellular process and has been reported to be chiefly mediated by the expression and activity of zinc-binding proteins such as metallothioneins and zinc transporters. Genes encoding for these proteins are subjected to genetic variants.
Methods: We performed a multi-database electronic search to provide an overview on the relationship between specific polymorphisms (SNP) of genes encoding for metallothioneins and zinc transporters and their relationship
with zinc status, immune function and some non-communicable diseases.
Results: A number of SNP are implicated in a range of metabolic disease. Some SNP may affect the impact of zinc supplementation on immune function, diabetes, and obesity.
Conclusion: New studies are needed to clarify the interaction between individual genetic profile and zinc status. Moreover, there is a need for a better interaction between the scientific bodies and health professionals to allow better dietary and behavioural recommendations to promote human health, with particular concern to elderly people.
LanguageEnglish
Pages1-13
Number of pages13
JournalCurrent Pharmaceutical Design
Volume24
Early online date30 Nov 2018
DOIs
Publication statusE-pub ahead of print - 30 Nov 2018

Fingerprint

Metabolic Diseases
Genetic Polymorphisms
Zinc
Single Nucleotide Polymorphism
Metallothionein
Human Body
Immune System Diseases
Health
Trace Elements
Energy Metabolism
Reproduction
Immunity
Homeostasis
Iron
Obesity
Antioxidants
Databases
Growth
Genes
zinc-binding protein

Keywords

  • Zinc
  • polymorphisms
  • Metallothionein
  • Zinc transporters
  • Immune function
  • Non- communicable disease

Cite this

Virgili, Fabio ; Ambra, Roberto ; McCormack, Jacqueline M. ; Simpson, Liz ; Ciarapica, Donatella ; Barnaba, Lorenzo ; Azzini, Elena ; Polito, Angela . / Genetic Polymorphisms and Zinc Status: Implications for Supplementation in Metabolic Diseases. In: Current Pharmaceutical Design. 2018 ; Vol. 24. pp. 1-13.
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Genetic Polymorphisms and Zinc Status: Implications for Supplementation in Metabolic Diseases. / Virgili, Fabio ; Ambra, Roberto ; McCormack, Jacqueline M.; Simpson, Liz; Ciarapica, Donatella ; Barnaba, Lorenzo ; Azzini, Elena ; Polito, Angela .

In: Current Pharmaceutical Design, Vol. 24, 30.11.2018, p. 1-13.

Research output: Contribution to journalArticle

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AU - Ambra, Roberto

AU - McCormack, Jacqueline M.

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AU - Barnaba, Lorenzo

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N2 - Background: Zinc is an essential component for all living organisms, representing the second most abundant trace element, after iron. This element is widely distributed in the tissues of a human body where it is involved in normal growth, reproduction and several biological functions including immunity, energy metabolism and antioxidant processes. Because of its essential role, zinc levels in the human body must remain constant, independently of dietary intake fluctuations. The homeostasis of zinc is a well-regulated cellular process and has been reported to be chiefly mediated by the expression and activity of zinc-binding proteins such as metallothioneins and zinc transporters. Genes encoding for these proteins are subjected to genetic variants.Methods: We performed a multi-database electronic search to provide an overview on the relationship between specific polymorphisms (SNP) of genes encoding for metallothioneins and zinc transporters and their relationshipwith zinc status, immune function and some non-communicable diseases.Results: A number of SNP are implicated in a range of metabolic disease. Some SNP may affect the impact of zinc supplementation on immune function, diabetes, and obesity.Conclusion: New studies are needed to clarify the interaction between individual genetic profile and zinc status. Moreover, there is a need for a better interaction between the scientific bodies and health professionals to allow better dietary and behavioural recommendations to promote human health, with particular concern to elderly people.

AB - Background: Zinc is an essential component for all living organisms, representing the second most abundant trace element, after iron. This element is widely distributed in the tissues of a human body where it is involved in normal growth, reproduction and several biological functions including immunity, energy metabolism and antioxidant processes. Because of its essential role, zinc levels in the human body must remain constant, independently of dietary intake fluctuations. The homeostasis of zinc is a well-regulated cellular process and has been reported to be chiefly mediated by the expression and activity of zinc-binding proteins such as metallothioneins and zinc transporters. Genes encoding for these proteins are subjected to genetic variants.Methods: We performed a multi-database electronic search to provide an overview on the relationship between specific polymorphisms (SNP) of genes encoding for metallothioneins and zinc transporters and their relationshipwith zinc status, immune function and some non-communicable diseases.Results: A number of SNP are implicated in a range of metabolic disease. Some SNP may affect the impact of zinc supplementation on immune function, diabetes, and obesity.Conclusion: New studies are needed to clarify the interaction between individual genetic profile and zinc status. Moreover, there is a need for a better interaction between the scientific bodies and health professionals to allow better dietary and behavioural recommendations to promote human health, with particular concern to elderly people.

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