Gene-directed enzyme prodrug therapy: A current assessment

SR McKeown, C Ward, T Robson

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)


    Gene-directed enzyme prodrug therapy involves tumor-specific delivery of a gene encoding a drug-metabolizing enzyme allowing metabolism of a non-toxic prodrug to a toxic species directly within tumor cells. This review covers the wide range of enzyme-prodrug combinations currently under preclinical and clinical investigation. Issues of tumor specificity and enhanced cytotoxicity through bystander effects will be discussed.
    Original languageEnglish
    Pages (from-to)421-435
    JournalCurrent Opinion in Molecular Therapeutics
    Issue number4
    Publication statusPublished (in print/issue) - Aug 2004


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