Gastrointestinal transit, post-prandial lipaemia and satiety following 3 days high-fat diet in men

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Abstract

BACKGROUND/OBJECTIVES: High-fat (HF) diets of 2 weeks have been shown to accelerate gastric emptying (GE). To date, no studies have shown any alteration in GE following shorter HF diets. The aim of this study was to assess if an HF, high-energy diet of 3 days can adapt gastrointestinal (GI) transit, blood lipids and satiety.SUBJECTS/METHODS: Eleven male volunteers participated in a study consisting of three, 3-day interventions each separated by a test day. During the first intervention, volunteers recorded their diet. In the second and third interventions, volunteers repeated their food diary plus either a low-fat yogurt or HF yogurt supplement in randomized order. Test days involved measurement of GE using the (13)C octanoic-acid breath-test, mouth-to-caecum transit time (MCTT) using the inulin H(2) breath test and satiety using visual analogue scales. Blood samples for measurement of lipaemia were taken using a venous cannula.RESULTS: MCTT was different between the three test days (P=0.038), with the shortest MCTT following the HF intervention. GE was shortest following the HF intervention. There were no differences in satiety between the interventions. The HF intervention reduced triglycerides, total cholesterol and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol.CONCLUSION: This study shows that changes in GI transit owing to an HF diet can occur in a time period as short as 3 days.
LanguageEnglish
Pages240-246
JournalEuropean Journal of Clinical Nutrition
Volume65
Issue number2
DOIs
Publication statusPublished - 2011

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Gastrointestinal Transit
High Fat Diet
Gastric Emptying
Meals
Fats
Mouth
Volunteers
Yogurt
Breath Tests
Diet Records
Inulin
Visual Analog Scale
LDL Cholesterol
HDL Cholesterol
Triglycerides
Cholesterol
Diet
Lipids

Keywords

  • gastric emptying
  • lipaemia
  • mouth-to-caecum transit time
  • satiety

Cite this

@article{b68fd738ad744d43bf3c3d4b043e5491,
title = "Gastrointestinal transit, post-prandial lipaemia and satiety following 3 days high-fat diet in men",
abstract = "BACKGROUND/OBJECTIVES: High-fat (HF) diets of 2 weeks have been shown to accelerate gastric emptying (GE). To date, no studies have shown any alteration in GE following shorter HF diets. The aim of this study was to assess if an HF, high-energy diet of 3 days can adapt gastrointestinal (GI) transit, blood lipids and satiety.SUBJECTS/METHODS: Eleven male volunteers participated in a study consisting of three, 3-day interventions each separated by a test day. During the first intervention, volunteers recorded their diet. In the second and third interventions, volunteers repeated their food diary plus either a low-fat yogurt or HF yogurt supplement in randomized order. Test days involved measurement of GE using the (13)C octanoic-acid breath-test, mouth-to-caecum transit time (MCTT) using the inulin H(2) breath test and satiety using visual analogue scales. Blood samples for measurement of lipaemia were taken using a venous cannula.RESULTS: MCTT was different between the three test days (P=0.038), with the shortest MCTT following the HF intervention. GE was shortest following the HF intervention. There were no differences in satiety between the interventions. The HF intervention reduced triglycerides, total cholesterol and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol.CONCLUSION: This study shows that changes in GI transit owing to an HF diet can occur in a time period as short as 3 days.",
keywords = "gastric emptying, lipaemia, mouth-to-caecum transit time, satiety",
author = "Conor McClean and Gareth Davison",
year = "2011",
doi = "10.1038/ejcn.2010.235",
language = "English",
volume = "65",
pages = "240--246",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
number = "2",

}

TY - JOUR

T1 - Gastrointestinal transit, post-prandial lipaemia and satiety following 3 days high-fat diet in men

AU - McClean, Conor

AU - Davison, Gareth

PY - 2011

Y1 - 2011

N2 - BACKGROUND/OBJECTIVES: High-fat (HF) diets of 2 weeks have been shown to accelerate gastric emptying (GE). To date, no studies have shown any alteration in GE following shorter HF diets. The aim of this study was to assess if an HF, high-energy diet of 3 days can adapt gastrointestinal (GI) transit, blood lipids and satiety.SUBJECTS/METHODS: Eleven male volunteers participated in a study consisting of three, 3-day interventions each separated by a test day. During the first intervention, volunteers recorded their diet. In the second and third interventions, volunteers repeated their food diary plus either a low-fat yogurt or HF yogurt supplement in randomized order. Test days involved measurement of GE using the (13)C octanoic-acid breath-test, mouth-to-caecum transit time (MCTT) using the inulin H(2) breath test and satiety using visual analogue scales. Blood samples for measurement of lipaemia were taken using a venous cannula.RESULTS: MCTT was different between the three test days (P=0.038), with the shortest MCTT following the HF intervention. GE was shortest following the HF intervention. There were no differences in satiety between the interventions. The HF intervention reduced triglycerides, total cholesterol and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol.CONCLUSION: This study shows that changes in GI transit owing to an HF diet can occur in a time period as short as 3 days.

AB - BACKGROUND/OBJECTIVES: High-fat (HF) diets of 2 weeks have been shown to accelerate gastric emptying (GE). To date, no studies have shown any alteration in GE following shorter HF diets. The aim of this study was to assess if an HF, high-energy diet of 3 days can adapt gastrointestinal (GI) transit, blood lipids and satiety.SUBJECTS/METHODS: Eleven male volunteers participated in a study consisting of three, 3-day interventions each separated by a test day. During the first intervention, volunteers recorded their diet. In the second and third interventions, volunteers repeated their food diary plus either a low-fat yogurt or HF yogurt supplement in randomized order. Test days involved measurement of GE using the (13)C octanoic-acid breath-test, mouth-to-caecum transit time (MCTT) using the inulin H(2) breath test and satiety using visual analogue scales. Blood samples for measurement of lipaemia were taken using a venous cannula.RESULTS: MCTT was different between the three test days (P=0.038), with the shortest MCTT following the HF intervention. GE was shortest following the HF intervention. There were no differences in satiety between the interventions. The HF intervention reduced triglycerides, total cholesterol and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol.CONCLUSION: This study shows that changes in GI transit owing to an HF diet can occur in a time period as short as 3 days.

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KW - lipaemia

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