Gastric ulcer healing by chebulinic acid solid dispersion-loaded gastroretentive raft systems: preclinical evidence

Poonam Negi, Surbhi Gautam, Aditi Sharma, Charul Rathore, Lalit Sharma, Navneet Upadhyay, Murtaza M Tambuwala, Dinesh Kumar Chellappan, Gaurav Gupta, Parteek Prasher, Kamal Dua, Shweta Agarwal, Uma Ranjan Lal

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Abstract

Background: Chebulinic acid (CA), a component in Terminalia chebula, exhibits antiulcer activity, but has poor aqueous solubility. Raft-forming systems incorporating solid dispersions (SDs) of CA, were developed to overcome its poor biopharmaceutical properties and to prolong the gastric residence time for maximum activity. Methods: SDs were formulated by a solvent evaporation method using Eudragit EPO. Raft formulations consisted of sodium alginate as a polymer. Results: Release of CA in the dissolution medium was 40%, whereas SDs showed 95.45% release. The CA raft system (20 mg/kg) showed curative efficacy in an alcohol-induced gastric ulcer model and increased protection when compared with omeprazole (10 mg/kg) and CA suspension (20 mg/kg). Conclusion: These studies demonstrated SD raft systems to be a promising approach for antiulcer therapy by CA.
Original languageEnglish
Pages (from-to)81-93
Number of pages13
JournalTherapeutic Delivery
Volume13
Issue number2
Early online date25 Jan 2022
DOIs
Publication statusPublished - 28 Feb 2022

Bibliographical note

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Keywords

  • Pharmaceutical formulations
  • raft system
  • solid dispersion
  • tablets
  • Eudragit EPO
  • Antiulcer
  • Terminalia chebula
  • chebulinic acid

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