GASTRIC-INHIBITORY POLYPEPTIDE AND INSULIN RESPONSES TO ORALLY-ADMINISTERED AMINO-ACIDS IN GENETICALLY-OBESE HYPERGLYCEMIC (OB/OB) MICE

Peter Flatt, P Kwasowski, RJ Howland, CJ Bailey

Research output: Contribution to journalArticle

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Abstract

The effects of oral administration of eight L-amino acids (alanine, arginine, cysteine, glycine, histidine, hydroxyproline, lysine and threonine) individually or as an amino acid mixture on plasma gastric inhibitory polypeptide (GIP), insulin and glucose concentrations were examined in 18-h fasted obese hyperglycemic (ob/ob) mice. At a dose of 5.4 mmol/kg body weight, arginine, cysteine, histidine and the amino acid mixture were equipotent in terms of increasing plasma GIP and insulin concentrations. Alanine, hydroxyproline and lysine also increased plasma GIP, but insulin concentrations were unchanged. In contrast, threonine failed to affect either GIP or insulin concentrations. There was no correlation between either the incremental or integrated GIP and insulin responses, and none of the amino acids administered affected circulating glucose concentrations. The results indicate that a range of essential and nonessential neutral and basic amino acids stimulate the release of GIP in ob/ob mice. However, GIP made only a modest contribution to the stimulation of insulin secretion following administration of amino acids in the presence of basal glycemia.
LanguageEnglish
Pages1123-1128
JournalJournal of Nutrition
Volume121
Issue number7
Publication statusPublished - Jul 1991

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Gastric Inhibitory Polypeptide
Insulin
Amino Acids
Hydroxyproline
Threonine
Histidine
Alanine
Lysine
Cysteine
Arginine
Neutral Amino Acids
Glucose
Basic Amino Acids
Glycine
Oral Administration
Body Weight

Cite this

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title = "GASTRIC-INHIBITORY POLYPEPTIDE AND INSULIN RESPONSES TO ORALLY-ADMINISTERED AMINO-ACIDS IN GENETICALLY-OBESE HYPERGLYCEMIC (OB/OB) MICE",
abstract = "The effects of oral administration of eight L-amino acids (alanine, arginine, cysteine, glycine, histidine, hydroxyproline, lysine and threonine) individually or as an amino acid mixture on plasma gastric inhibitory polypeptide (GIP), insulin and glucose concentrations were examined in 18-h fasted obese hyperglycemic (ob/ob) mice. At a dose of 5.4 mmol/kg body weight, arginine, cysteine, histidine and the amino acid mixture were equipotent in terms of increasing plasma GIP and insulin concentrations. Alanine, hydroxyproline and lysine also increased plasma GIP, but insulin concentrations were unchanged. In contrast, threonine failed to affect either GIP or insulin concentrations. There was no correlation between either the incremental or integrated GIP and insulin responses, and none of the amino acids administered affected circulating glucose concentrations. The results indicate that a range of essential and nonessential neutral and basic amino acids stimulate the release of GIP in ob/ob mice. However, GIP made only a modest contribution to the stimulation of insulin secretion following administration of amino acids in the presence of basal glycemia.",
author = "Peter Flatt and P Kwasowski and RJ Howland and CJ Bailey",
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journal = "Journal of Nutrition",
issn = "0022-3166",
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GASTRIC-INHIBITORY POLYPEPTIDE AND INSULIN RESPONSES TO ORALLY-ADMINISTERED AMINO-ACIDS IN GENETICALLY-OBESE HYPERGLYCEMIC (OB/OB) MICE. / Flatt, Peter; Kwasowski, P; Howland, RJ; Bailey, CJ.

In: Journal of Nutrition, Vol. 121, No. 7, 07.1991, p. 1123-1128.

Research output: Contribution to journalArticle

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AB - The effects of oral administration of eight L-amino acids (alanine, arginine, cysteine, glycine, histidine, hydroxyproline, lysine and threonine) individually or as an amino acid mixture on plasma gastric inhibitory polypeptide (GIP), insulin and glucose concentrations were examined in 18-h fasted obese hyperglycemic (ob/ob) mice. At a dose of 5.4 mmol/kg body weight, arginine, cysteine, histidine and the amino acid mixture were equipotent in terms of increasing plasma GIP and insulin concentrations. Alanine, hydroxyproline and lysine also increased plasma GIP, but insulin concentrations were unchanged. In contrast, threonine failed to affect either GIP or insulin concentrations. There was no correlation between either the incremental or integrated GIP and insulin responses, and none of the amino acids administered affected circulating glucose concentrations. The results indicate that a range of essential and nonessential neutral and basic amino acids stimulate the release of GIP in ob/ob mice. However, GIP made only a modest contribution to the stimulation of insulin secretion following administration of amino acids in the presence of basal glycemia.

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