TY - JOUR
T1 - Furanone quorum-sensing inhibitors with potential as novel therapeutics against Pseudomonas aeruginosa
AU - Proctor, Chris
AU - McCarron, P. A.
AU - Ternan, Nigel G
N1 - Funding Information:
C.R.P. was supported by a Department for the Economy (Northern Ireland) Ph.D. studentship (2017-2020). P.A.M. and N.G.T. were supported by strategic funding from the Biomedical Sciences Research Institute, University of Ulster, Coleraine.
Publisher Copyright:
© 2020 The Authors.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/1/23
Y1 - 2020/1/23
N2 - Micro-organisms use quorum sensing (QS), a cell density-dependent process, to communicate. This QS mode of interchange leads to the production of a variety of virulence factors, co-ordination of complex bacterial behaviours, such as swarming motility, degradation of host tissue and biofilm formation. QS is implicated in numerous human infections and consequently researchers have sought ways of effectively inhibiting the process in pathogenic bacteria. Two decades ago, furanones were the first class of chemical compounds identified as Pseudomonas aeruginosa QS inhibitors (QSIs). P. aeruginosa is a ubiquitous organism, capable of causing a wide range of infections in humans, including eye and ear infections, wound infections and potentially fatal bacteraemia and thus novel treatments against this organism are greatly needed. This review provides a brief background on QS and the use of furanones as QSIs. Based on the effectiveness of action, both in vivo and in vitro, we will explore the use of furanones as potential antimicrobial therapeutics and conclude with open questions.
AB - Micro-organisms use quorum sensing (QS), a cell density-dependent process, to communicate. This QS mode of interchange leads to the production of a variety of virulence factors, co-ordination of complex bacterial behaviours, such as swarming motility, degradation of host tissue and biofilm formation. QS is implicated in numerous human infections and consequently researchers have sought ways of effectively inhibiting the process in pathogenic bacteria. Two decades ago, furanones were the first class of chemical compounds identified as Pseudomonas aeruginosa QS inhibitors (QSIs). P. aeruginosa is a ubiquitous organism, capable of causing a wide range of infections in humans, including eye and ear infections, wound infections and potentially fatal bacteraemia and thus novel treatments against this organism are greatly needed. This review provides a brief background on QS and the use of furanones as QSIs. Based on the effectiveness of action, both in vivo and in vitro, we will explore the use of furanones as potential antimicrobial therapeutics and conclude with open questions.
KW - Pseudomonas and furanone
KW - quorum sensing
KW - biofilm
KW - therapeutic
UR - http://www.scopus.com/inward/record.url?scp=85080045771&partnerID=8YFLogxK
U2 - https://doi.org/10.1099/jmm.0.001144
DO - https://doi.org/10.1099/jmm.0.001144
M3 - Review article
VL - 69
SP - 195
EP - 206
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
SN - 0022-2615
IS - 2
ER -