Abstract
Skin secretions of several frog species contain host-defense peptides with multiple biological activities including in vitro and in vivo insulin-releasing actions. This study investigates the effects of tigerinin-1R from Hoplobatrachus rugulosus (Dicroglossidae) and magainin-AM1, magainin-AM2, caerulein precursor fragment (CPF-AM1) and peptide glycine leucine amide (PGLa-AM1) from Xenopus amieti (Pipidae) on GLP-1 secretion from GLUTag cells. Tigerinin-1R showed the highest potency producing a significant (P
| Original language | English |
|---|---|
| Pages (from-to) | 14-18 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 431 |
| DOIs | |
| Publication status | Published - 3 Jan 2013 |
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Ojo, OO., Conlon, JM., Flatt, P., & Abdel-Wahab, Y. (2013). Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells. Biochemical and Biophysical Research Communications, 431, 14-18. https://doi.org/10.1016/j.bbrc.2012.12.116