Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells.

OO Ojo, JM Conlon, Peter Flatt, Yasser Abdel-Wahab

Research output: Contribution to journal › Article

23 Citations (Scopus)

Abstract

Skin secretions of several frog species contain host-defense peptides with multiple biological activities including in vitro and in vivo insulin-releasing actions. This study investigates the effects of tigerinin-1R from Hoplobatrachus rugulosus (Dicroglossidae) and magainin-AM1, magainin-AM2, caerulein precursor fragment (CPF-AM1) and peptide glycine leucine amide (PGLa-AM1) from Xenopus amieti (Pipidae) on GLP-1 secretion from GLUTag cells. Tigerinin-1R showed the highest potency producing a significant (P
Original languageEnglish
Pages (from-to)14-18
JournalBiochemical and Biophysical Research Communications
Volume431
DOIs
Publication statusPublished - 3 Jan 2013

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Magainins
Glucagon-Like Peptide 1
Anura
Pipidae
Skin
Ceruletide
Peptides
Xenopus
Bioactivity
Amides
Leucine
Glycine
Insulin

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Ojo, OO ; Conlon, JM ; Flatt, Peter ; Abdel-Wahab, Yasser. / Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells. In: Biochemical and Biophysical Research Communications. 2013 ; Vol. 431. pp. 14-18.
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title = "Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells.",
abstract = "Skin secretions of several frog species contain host-defense peptides with multiple biological activities including in vitro and in vivo insulin-releasing actions. This study investigates the effects of tigerinin-1R from Hoplobatrachus rugulosus (Dicroglossidae) and magainin-AM1, magainin-AM2, caerulein precursor fragment (CPF-AM1) and peptide glycine leucine amide (PGLa-AM1) from Xenopus amieti (Pipidae) on GLP-1 secretion from GLUTag cells. Tigerinin-1R showed the highest potency producing a significant (P",
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Ojo, OO, Conlon, JM, Flatt, P & Abdel-Wahab, Y 2013, 'Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells.', Biochemical and Biophysical Research Communications, vol. 431, pp. 14-18. https://doi.org/10.1016/j.bbrc.2012.12.116

Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells. / Ojo, OO; Conlon, JM; Flatt, Peter; Abdel-Wahab, Yasser.

In: Biochemical and Biophysical Research Communications, Vol. 431, 03.01.2013, p. 14-18.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells.

AU - Ojo, OO

AU - Conlon, JM

AU - Flatt, Peter

AU - Abdel-Wahab, Yasser

PY - 2013/1/3

Y1 - 2013/1/3

N2 - Skin secretions of several frog species contain host-defense peptides with multiple biological activities including in vitro and in vivo insulin-releasing actions. This study investigates the effects of tigerinin-1R from Hoplobatrachus rugulosus (Dicroglossidae) and magainin-AM1, magainin-AM2, caerulein precursor fragment (CPF-AM1) and peptide glycine leucine amide (PGLa-AM1) from Xenopus amieti (Pipidae) on GLP-1 secretion from GLUTag cells. Tigerinin-1R showed the highest potency producing a significant (P

AB - Skin secretions of several frog species contain host-defense peptides with multiple biological activities including in vitro and in vivo insulin-releasing actions. This study investigates the effects of tigerinin-1R from Hoplobatrachus rugulosus (Dicroglossidae) and magainin-AM1, magainin-AM2, caerulein precursor fragment (CPF-AM1) and peptide glycine leucine amide (PGLa-AM1) from Xenopus amieti (Pipidae) on GLP-1 secretion from GLUTag cells. Tigerinin-1R showed the highest potency producing a significant (P

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DO - 10.1016/j.bbrc.2012.12.116

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

ER -

Ojo OO, Conlon JM, Flatt P, Abdel-Wahab Y. Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells. Biochemical and Biophysical Research Communications. 2013 Jan 3;431:14-18. https://doi.org/10.1016/j.bbrc.2012.12.116

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