Abstract
Skin secretions of several frog species contain host-defense peptides with multiple biological activities including in vitro and in vivo insulin-releasing actions. This study investigates the effects of tigerinin-1R from Hoplobatrachus rugulosus (Dicroglossidae) and magainin-AM1, magainin-AM2, caerulein precursor fragment (CPF-AM1) and peptide glycine leucine amide (PGLa-AM1) from Xenopus amieti (Pipidae) on GLP-1 secretion from GLUTag cells. Tigerinin-1R showed the highest potency producing a significant (P
Original language | English |
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Pages (from-to) | 14-18 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 431 |
DOIs | |
Publication status | Published (in print/issue) - 3 Jan 2013 |