Fragments of prosomatostatin isolated from a human pancreatic tumour

J. M. Conlon; D. M. McCarthy

doi:10.1016/0303-7207(84)90148-5

Fragments of prosomatostatin isolated from a human pancreatic tumour

J. M. Conlon, D. M. McCarthy

School of Biomedical Sciences

Department of Veterans Affairs

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Six peptides from an extract of a human pancreatic tumour were purified to homogeneity by HPLC. Amino acid composition and chemical properties indicated probable structures the same as somatostatin-14, somatostatin-28 (1-12), [Met(O)⁸]somatostatin-28 (1-12), [Met(O)⁸]somatostatin-28 (1-10), somatostatin-25 (1-9) and [Met(O)³]somatostatin-25 (1-9). The structure of somatostatin-14 was confirmed by sequence analysis. The isolation of these peptides provides insight into the processing of prosomatostatin in the tumour cells.

Original language	English
Pages (from-to)	81-86
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/0303-7207(84)90148-5
Publication status	Published (in print/issue) - Nov 1984

Keywords

HPLC
limited proteolysis
methionine oxidation

Access to Document

10.1016/0303-7207(84)90148-5

Cite this

@article{f267b305433849feb7e9957428019e6d,

title = "Fragments of prosomatostatin isolated from a human pancreatic tumour",

abstract = "Six peptides from an extract of a human pancreatic tumour were purified to homogeneity by HPLC. Amino acid composition and chemical properties indicated probable structures the same as somatostatin-14, somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-10), somatostatin-25 (1-9) and [Met(O)3]somatostatin-25 (1-9). The structure of somatostatin-14 was confirmed by sequence analysis. The isolation of these peptides provides insight into the processing of prosomatostatin in the tumour cells.",

keywords = "HPLC, limited proteolysis, methionine oxidation",

author = "Conlon, \{J. M.\} and McCarthy, \{D. M.\}",

year = "1984",

month = nov,

doi = "10.1016/0303-7207(84)90148-5",

language = "English",

volume = "38",

pages = "81--86",

journal = "Molecular and Cellular Endocrinology",

issn = "0303-7207",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Fragments of prosomatostatin isolated from a human pancreatic tumour

AU - Conlon, J. M.

AU - McCarthy, D. M.

PY - 1984/11

Y1 - 1984/11

N2 - Six peptides from an extract of a human pancreatic tumour were purified to homogeneity by HPLC. Amino acid composition and chemical properties indicated probable structures the same as somatostatin-14, somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-10), somatostatin-25 (1-9) and [Met(O)3]somatostatin-25 (1-9). The structure of somatostatin-14 was confirmed by sequence analysis. The isolation of these peptides provides insight into the processing of prosomatostatin in the tumour cells.

AB - Six peptides from an extract of a human pancreatic tumour were purified to homogeneity by HPLC. Amino acid composition and chemical properties indicated probable structures the same as somatostatin-14, somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-10), somatostatin-25 (1-9) and [Met(O)3]somatostatin-25 (1-9). The structure of somatostatin-14 was confirmed by sequence analysis. The isolation of these peptides provides insight into the processing of prosomatostatin in the tumour cells.

KW - HPLC

KW - limited proteolysis

KW - methionine oxidation

UR - https://www.scopus.com/pages/publications/0021673246

U2 - 10.1016/0303-7207(84)90148-5

DO - 10.1016/0303-7207(84)90148-5

M3 - Article

C2 - 6151529

AN - SCOPUS:0021673246

SN - 0303-7207

VL - 38

SP - 81

EP - 86

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

IS - 1

ER -

Fragments of prosomatostatin isolated from a human pancreatic tumour

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this