Abstract
Six peptides from an extract of a human pancreatic tumour were purified to homogeneity by HPLC. Amino acid composition and chemical properties indicated probable structures the same as somatostatin-14, somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-10), somatostatin-25 (1-9) and [Met(O)3]somatostatin-25 (1-9). The structure of somatostatin-14 was confirmed by sequence analysis. The isolation of these peptides provides insight into the processing of prosomatostatin in the tumour cells.
| Original language | English |
|---|---|
| Pages (from-to) | 81-86 |
| Number of pages | 6 |
| Journal | Molecular and Cellular Endocrinology |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published (in print/issue) - Nov 1984 |
Funding
The authors wish to thank the Stiftung Volkswagenwerk for financial support and Profes- sor Dr. N. Hilschmann, Max-Planck-Institut fur Experimentelle Medizin, for providing facilities for amino acid analysis.
| Funders |
|---|
| Max-Planck-Institut fur Experimentelle Medizin |
Keywords
- HPLC
- limited proteolysis
- methionine oxidation
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