Fragments of prosomatostatin isolated from a human pancreatic tumour

J. M. Conlon, D. M. McCarthy

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26 Citations (Scopus)


Six peptides from an extract of a human pancreatic tumour were purified to homogeneity by HPLC. Amino acid composition and chemical properties indicated probable structures the same as somatostatin-14, somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-10), somatostatin-25 (1-9) and [Met(O)3]somatostatin-25 (1-9). The structure of somatostatin-14 was confirmed by sequence analysis. The isolation of these peptides provides insight into the processing of prosomatostatin in the tumour cells.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalMolecular and Cellular Endocrinology
Issue number1
Publication statusPublished (in print/issue) - Nov 1984


  • HPLC
  • limited proteolysis
  • methionine oxidation


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