TY - JOUR
T1 - Fragments of prosomatostatin isolated from a human pancreatic tumour
AU - Conlon, J. M.
AU - McCarthy, D. M.
PY - 1984/11
Y1 - 1984/11
N2 - Six peptides from an extract of a human pancreatic tumour were purified to homogeneity by HPLC. Amino acid composition and chemical properties indicated probable structures the same as somatostatin-14, somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-10), somatostatin-25 (1-9) and [Met(O)3]somatostatin-25 (1-9). The structure of somatostatin-14 was confirmed by sequence analysis. The isolation of these peptides provides insight into the processing of prosomatostatin in the tumour cells.
AB - Six peptides from an extract of a human pancreatic tumour were purified to homogeneity by HPLC. Amino acid composition and chemical properties indicated probable structures the same as somatostatin-14, somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-10), somatostatin-25 (1-9) and [Met(O)3]somatostatin-25 (1-9). The structure of somatostatin-14 was confirmed by sequence analysis. The isolation of these peptides provides insight into the processing of prosomatostatin in the tumour cells.
KW - HPLC
KW - limited proteolysis
KW - methionine oxidation
UR - http://www.scopus.com/inward/record.url?scp=0021673246&partnerID=8YFLogxK
U2 - 10.1016/0303-7207(84)90148-5
DO - 10.1016/0303-7207(84)90148-5
M3 - Article
C2 - 6151529
AN - SCOPUS:0021673246
SN - 0303-7207
VL - 38
SP - 81
EP - 86
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1
ER -