Formulation Development and Evaluation of Pravastatin-Loaded Nanogel for Hyperlipidemia Management

Gaurav Kant Saraogi, Siddharth Tholiya, Yachana Mishra, Vijay Mishra, Aqel Albutti, Pallavi Nayak, Murtaza M. Tambuwala

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1 Citation (Scopus)
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Abstract

Hyperlipidemia is a crucial risk factor for the initiation and progression of atherosclerosis, ultimately leading to cardiovascular disease. The nanogel-based nanoplatform has emerged as an extremely promising drug delivery technology. Pravastatin Sodium (PS) is a cholesterol-lowering drug used to treat hyperlipidemia. This study aimed to fabricate Pravastatin-loaded nanogel for evaluation of its effect in hyperlipidemia treatment. Pravastatin-loaded chitosan nanoparticles (PS-CS-NPs) were prepared by the ionic gelation method; then, these prepared NPs were converted to nanogel by adding a specified amount of 5% poloxamer solution. Various parameters, including drug entrapment efficacy, in vitro drug release, and hemolytic activity of the developed and optimized formulation, were evaluated. The in vitro drug release of the nanogel formulation revealed the sustained release (59.63% in 24 h) of the drug. The drug excipients compatibility studies revealed no interaction between the drug and the screened excipients. Higher drug entrapment efficacy was observed. The hemolytic activity showed lesser toxicity in nanoformulation than the pure drug solution. These findings support the prospective use of orally administered pravastatin-loaded nanogel as an effective and safe nano delivery system in hyperlipidemia treatment.
Original languageEnglish
Article number81
Number of pages14
JournalGels
Volume8
Issue number2
DOIs
Publication statusPublished - 28 Jan 2022

Bibliographical note

Funding Information:
Funding: The researchers would like to thank the Deanship of Scientific Research (DSR), Qassim University for funding the publication of this project.

Funding Information:
Acknowledgments: The authors acknowledge DSR, Qassim University for financial support.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • nano-gel
  • hyperlipidemia
  • Polymers
  • gels
  • pravastatin
  • Nanogel
  • Hyperlipidemia
  • Polymer
  • Pravastatin

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