Folic acid supplementation in late gestation and the effects on DNA methylation in the offspring

Research output: Contribution to conferenceAbstract

Abstract

Increasingly accurate surveys of human health throughout the life course has led experts to propose that stresses on the child while still in the mother’s womb can affect the individual’s health much later in life. Such long-term effects on health are thought to be mediated by a semi-permanent trace on the genes of the affected person called an epigenetic mark. Epigenetic mechanisms, such as DNA methylation, are dynamic during pregnancy whereby epigenetic marks are seeded which persist throughout the lifetime of the developing child. It has been suggested that these patterns may be altered by the mother’s diet, particularly folate – a key component in the DNA methylation cycle. Currently, mothers are universally recommended to supplement their diet with 400μg folic acid/day as a preventative measure against neural tube defects in the offspring prior to and during the first trimester. However, there remains no clinical recommendation as to whether mothers should continue supplementation during the final two trimesters and the potentially heritable effects on DNA methylation. Observational studies have suggested that folate-rich maternal diets are associated with changes in DNA methylation of the child during this period of gestation. We present here the results of a randomised control trial (FASSTT study) examining the effects of folic acid supplementation in late gestation (week 12 onwards) on DNA methylation of several gene classes in offspring cord blood samples. We report small but significant sex-specific differences between the two intervention groups. These preliminary results indicate that folic acid supplementation throughout pregnancy may exert significant effects on cord blood DNA methylation.

Conference

Conference19th Meeting of the Irish Society of Human Genetics,
CountryUnited Kingdom
CityBelfast
Period9/09/169/09/16
Internet address

Fingerprint

DNA Methylation
Folic Acid
Pregnancy
Mothers
Epigenomics
Diet
Fetal Blood
Neural Tube Defects
Health
First Pregnancy Trimester
Health Surveys
Sex Characteristics
Genes
Observational Studies

Cite this

@conference{1086db173b604aad8047eb213b0c8257,
title = "Folic acid supplementation in late gestation and the effects on DNA methylation in the offspring",
abstract = "Increasingly accurate surveys of human health throughout the life course has led experts to propose that stresses on the child while still in the mother’s womb can affect the individual’s health much later in life. Such long-term effects on health are thought to be mediated by a semi-permanent trace on the genes of the affected person called an epigenetic mark. Epigenetic mechanisms, such as DNA methylation, are dynamic during pregnancy whereby epigenetic marks are seeded which persist throughout the lifetime of the developing child. It has been suggested that these patterns may be altered by the mother’s diet, particularly folate – a key component in the DNA methylation cycle. Currently, mothers are universally recommended to supplement their diet with 400μg folic acid/day as a preventative measure against neural tube defects in the offspring prior to and during the first trimester. However, there remains no clinical recommendation as to whether mothers should continue supplementation during the final two trimesters and the potentially heritable effects on DNA methylation. Observational studies have suggested that folate-rich maternal diets are associated with changes in DNA methylation of the child during this period of gestation. We present here the results of a randomised control trial (FASSTT study) examining the effects of folic acid supplementation in late gestation (week 12 onwards) on DNA methylation of several gene classes in offspring cord blood samples. We report small but significant sex-specific differences between the two intervention groups. These preliminary results indicate that folic acid supplementation throughout pregnancy may exert significant effects on cord blood DNA methylation.",
author = "Irwin, {Rachelle E} and Aoife Caffrey and K. Pentieva and H McNulty and CP Walsh",
year = "2017",
language = "English",
pages = "67",
note = "19th Meeting of the Irish Society of Human Genetics, ; Conference date: 09-09-2016 Through 09-09-2016",
url = "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324189/",

}

Irwin, RE, Caffrey, A, Pentieva, K, McNulty, H & Walsh, CP 2017, 'Folic acid supplementation in late gestation and the effects on DNA methylation in the offspring' 19th Meeting of the Irish Society of Human Genetics, Belfast, United Kingdom, 9/09/16 - 9/09/16, pp. 67.

Folic acid supplementation in late gestation and the effects on DNA methylation in the offspring. / Irwin, Rachelle E; Caffrey, Aoife; Pentieva, K.; McNulty, H; Walsh, CP.

2017. 67 Abstract from 19th Meeting of the Irish Society of Human Genetics, Belfast, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Folic acid supplementation in late gestation and the effects on DNA methylation in the offspring

AU - Irwin, Rachelle E

AU - Caffrey, Aoife

AU - Pentieva, K.

AU - McNulty, H

AU - Walsh, CP

PY - 2017

Y1 - 2017

N2 - Increasingly accurate surveys of human health throughout the life course has led experts to propose that stresses on the child while still in the mother’s womb can affect the individual’s health much later in life. Such long-term effects on health are thought to be mediated by a semi-permanent trace on the genes of the affected person called an epigenetic mark. Epigenetic mechanisms, such as DNA methylation, are dynamic during pregnancy whereby epigenetic marks are seeded which persist throughout the lifetime of the developing child. It has been suggested that these patterns may be altered by the mother’s diet, particularly folate – a key component in the DNA methylation cycle. Currently, mothers are universally recommended to supplement their diet with 400μg folic acid/day as a preventative measure against neural tube defects in the offspring prior to and during the first trimester. However, there remains no clinical recommendation as to whether mothers should continue supplementation during the final two trimesters and the potentially heritable effects on DNA methylation. Observational studies have suggested that folate-rich maternal diets are associated with changes in DNA methylation of the child during this period of gestation. We present here the results of a randomised control trial (FASSTT study) examining the effects of folic acid supplementation in late gestation (week 12 onwards) on DNA methylation of several gene classes in offspring cord blood samples. We report small but significant sex-specific differences between the two intervention groups. These preliminary results indicate that folic acid supplementation throughout pregnancy may exert significant effects on cord blood DNA methylation.

AB - Increasingly accurate surveys of human health throughout the life course has led experts to propose that stresses on the child while still in the mother’s womb can affect the individual’s health much later in life. Such long-term effects on health are thought to be mediated by a semi-permanent trace on the genes of the affected person called an epigenetic mark. Epigenetic mechanisms, such as DNA methylation, are dynamic during pregnancy whereby epigenetic marks are seeded which persist throughout the lifetime of the developing child. It has been suggested that these patterns may be altered by the mother’s diet, particularly folate – a key component in the DNA methylation cycle. Currently, mothers are universally recommended to supplement their diet with 400μg folic acid/day as a preventative measure against neural tube defects in the offspring prior to and during the first trimester. However, there remains no clinical recommendation as to whether mothers should continue supplementation during the final two trimesters and the potentially heritable effects on DNA methylation. Observational studies have suggested that folate-rich maternal diets are associated with changes in DNA methylation of the child during this period of gestation. We present here the results of a randomised control trial (FASSTT study) examining the effects of folic acid supplementation in late gestation (week 12 onwards) on DNA methylation of several gene classes in offspring cord blood samples. We report small but significant sex-specific differences between the two intervention groups. These preliminary results indicate that folic acid supplementation throughout pregnancy may exert significant effects on cord blood DNA methylation.

M3 - Abstract

SP - 67

ER -

Irwin RE, Caffrey A, Pentieva K, McNulty H, Walsh CP. Folic acid supplementation in late gestation and the effects on DNA methylation in the offspring. 2017. Abstract from 19th Meeting of the Irish Society of Human Genetics, Belfast, United Kingdom.