Fish oil supplementation with and without added vitamin E differentially modulates plasma antioxidant concentrations in healthy women

E Turley, Julie Wallace, WS Gilmore, JJ Strain

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13 Citations (Scopus)


The purpose of this study was to assess the effect of fish oil with or without vitamin E on plasma vitamin antioxidants. Thirty-three apparently healthy women aged 18-28 yr were recruited from the university environs, and 30 completed the double-blinded, parallel design supplementation trial. Blood samples were collected at baseline (week 0) and following 28 d of supplementation with three capsules/d (0.8 g x 3) of either fish oil (FO) or FO with vitamin E (3 IU/g) (FOE). An additional blood sample was taken at day 91 (washout). Plasma antioxidant vitamins, fatty acid composition, and lipid peroxides were measured. Plasma alpha-tocopherol concentrations were increased significantly in both groups postsupplementation FO (P = 0.018) and FOE (P = 0.003) compared with baseline and washout values. Plasma retinol concentration was significantly increased (P = 0.034) compared with baseline and washout values following supplementation with FOE but not FO, while plasma beta-carotene was significantly increased (P = 0.036), compared with baseline and washout values, following supplementation with FO but not FOE. There was a trend (P = 0.059) toward decreased plasma ascorbic acid following FO supplementation compared with baseline and washout. Plasma lipid peroxides did not change following either supplementation. Results suggest that low-dose FO feeding with and without vitamin E differentially modulates plasma antioxidant vitamins but has no significant effect on lipid peroxidation.
Original languageEnglish
Pages (from-to)1163-1167
Issue number12
Publication statusPublished - Dec 1998


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