First trimester medication use in pregnancy in Cameroon: a multi-hospital survey

Aminkeng Zawuo Leke, Helen Dolk, Maria Loane, K. Casson, Nkwati Michel Maboh, Susan Etta Maeya, Lerry Dibo Ndumbe, Pauline Bessem Nyenti, Obale Armstrong, Derick Etiendem

Research output: Contribution to journalArticle

Abstract

Background
There is a paucity of epidemiological data on medication use in pregnancy in Cameroon.

Methods
Between March and August 2015, 795 pregnant women attending 8 urban and 12 rural hospitals in Cameroon for antenatal (ANC) or other care were interviewed on first trimester medication use using structured questionnaires. Multivariate logistic regression was used to analyse the association of 18 sociodemographic factors with medication use.

Results
A total of 582 (73.2%) women took at least one orthodox (Western) medication during the first trimester, 543 (68.3%) women a non-pregnancy related orthodox medication, and 336 (42.3%)women a pregnancy related orthodox medication. 44% of the women took anti-infectives including antimalarials (33.6%) and antibiotics (20.8%).The other most common medications were analgesics (48.8%) and antianaemias (38.6%). Sulfadoxine/pyrimethamine, contraindicated in the first trimester of pregnancy, was the most commonly used antimalarial(13% of women).0.2% of women reported antiretroviral use. Almost 80% of all orthodox medications consumed by women were purchased from the hospital. 12.8% of the women self-prescribed. Health unit and early gestational age at ANC booking were consistent determinants of prescribing of non-pregnancy related, pregnancy related and anti-infective medications. Illness and opinion on the safety of orthodox medications were determinants of the use of non-pregnancy related medications and anti-infectives. Age and parity were associated only with non-pregnancy related medications.

Conclusion
This study has confirmed the observations of studies across Africa indicating the increasing use of medications during pregnancy. This is an indication that access to medicine is improving and more emphasis now must be placed on medication safety systems targeting pregnant women, especially during the first trimester when the risk of teratogenicity is highest.
LanguageEnglish
Article number450
Number of pages15
JournalBMC Pregnancy and Childbirth
Volume18
Issue number1
Early online date20 Nov 2018
DOIs
Publication statusPublished - Dec 2018

Fingerprint

Cameroon
First Pregnancy Trimester
Pregnancy
Antimalarials
Pregnant Women
Medication Systems
Safety
Rural Hospitals
Surveys and Questionnaires
Parity
Gestational Age
Analgesics
Logistic Models
Medicine
Anti-Bacterial Agents
Health

Keywords

  • Medication
  • pregnancy
  • drug safety
  • drug use
  • pharmacoepidemiology
  • determinants
  • pharmacovigilance
  • Cameroon

Cite this

Leke, Aminkeng Zawuo ; Dolk, Helen ; Loane, Maria ; Casson, K. ; Maboh, Nkwati Michel ; Maeya, Susan Etta ; Ndumbe, Lerry Dibo ; Nyenti, Pauline Bessem ; Armstrong, Obale ; Etiendem, Derick. / First trimester medication use in pregnancy in Cameroon: a multi-hospital survey. In: BMC Pregnancy and Childbirth. 2018 ; Vol. 18, No. 1.
@article{71cd5fa7ef3048778c208f9e8a119be1,
title = "First trimester medication use in pregnancy in Cameroon: a multi-hospital survey",
abstract = "BackgroundThere is a paucity of epidemiological data on medication use in pregnancy in Cameroon.MethodsBetween March and August 2015, 795 pregnant women attending 8 urban and 12 rural hospitals in Cameroon for antenatal (ANC) or other care were interviewed on first trimester medication use using structured questionnaires. Multivariate logistic regression was used to analyse the association of 18 sociodemographic factors with medication use.ResultsA total of 582 (73.2{\%}) women took at least one orthodox (Western) medication during the first trimester, 543 (68.3{\%}) women a non-pregnancy related orthodox medication, and 336 (42.3{\%})women a pregnancy related orthodox medication. 44{\%} of the women took anti-infectives including antimalarials (33.6{\%}) and antibiotics (20.8{\%}).The other most common medications were analgesics (48.8{\%}) and antianaemias (38.6{\%}). Sulfadoxine/pyrimethamine, contraindicated in the first trimester of pregnancy, was the most commonly used antimalarial(13{\%} of women).0.2{\%} of women reported antiretroviral use. Almost 80{\%} of all orthodox medications consumed by women were purchased from the hospital. 12.8{\%} of the women self-prescribed. Health unit and early gestational age at ANC booking were consistent determinants of prescribing of non-pregnancy related, pregnancy related and anti-infective medications. Illness and opinion on the safety of orthodox medications were determinants of the use of non-pregnancy related medications and anti-infectives. Age and parity were associated only with non-pregnancy related medications.ConclusionThis study has confirmed the observations of studies across Africa indicating the increasing use of medications during pregnancy. This is an indication that access to medicine is improving and more emphasis now must be placed on medication safety systems targeting pregnant women, especially during the first trimester when the risk of teratogenicity is highest.",
keywords = "Medication, pregnancy, drug safety, drug use, pharmacoepidemiology, determinants, pharmacovigilance, Cameroon",
author = "Leke, {Aminkeng Zawuo} and Helen Dolk and Maria Loane and K. Casson and Maboh, {Nkwati Michel} and Maeya, {Susan Etta} and Ndumbe, {Lerry Dibo} and Nyenti, {Pauline Bessem} and Obale Armstrong and Derick Etiendem",
year = "2018",
month = "12",
doi = "10.1186/s12884-018-2081-x",
language = "English",
volume = "18",
journal = "BMC Pregnancy and Childbirth",
issn = "1471-2393",
publisher = "BioMed Central",
number = "1",

}

First trimester medication use in pregnancy in Cameroon: a multi-hospital survey. / Leke, Aminkeng Zawuo; Dolk, Helen; Loane, Maria; Casson, K.; Maboh, Nkwati Michel; Maeya, Susan Etta ; Ndumbe, Lerry Dibo; Nyenti, Pauline Bessem; Armstrong, Obale; Etiendem, Derick.

In: BMC Pregnancy and Childbirth, Vol. 18, No. 1, 450, 12.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - First trimester medication use in pregnancy in Cameroon: a multi-hospital survey

AU - Leke, Aminkeng Zawuo

AU - Dolk, Helen

AU - Loane, Maria

AU - Casson, K.

AU - Maboh, Nkwati Michel

AU - Maeya, Susan Etta

AU - Ndumbe, Lerry Dibo

AU - Nyenti, Pauline Bessem

AU - Armstrong, Obale

AU - Etiendem, Derick

PY - 2018/12

Y1 - 2018/12

N2 - BackgroundThere is a paucity of epidemiological data on medication use in pregnancy in Cameroon.MethodsBetween March and August 2015, 795 pregnant women attending 8 urban and 12 rural hospitals in Cameroon for antenatal (ANC) or other care were interviewed on first trimester medication use using structured questionnaires. Multivariate logistic regression was used to analyse the association of 18 sociodemographic factors with medication use.ResultsA total of 582 (73.2%) women took at least one orthodox (Western) medication during the first trimester, 543 (68.3%) women a non-pregnancy related orthodox medication, and 336 (42.3%)women a pregnancy related orthodox medication. 44% of the women took anti-infectives including antimalarials (33.6%) and antibiotics (20.8%).The other most common medications were analgesics (48.8%) and antianaemias (38.6%). Sulfadoxine/pyrimethamine, contraindicated in the first trimester of pregnancy, was the most commonly used antimalarial(13% of women).0.2% of women reported antiretroviral use. Almost 80% of all orthodox medications consumed by women were purchased from the hospital. 12.8% of the women self-prescribed. Health unit and early gestational age at ANC booking were consistent determinants of prescribing of non-pregnancy related, pregnancy related and anti-infective medications. Illness and opinion on the safety of orthodox medications were determinants of the use of non-pregnancy related medications and anti-infectives. Age and parity were associated only with non-pregnancy related medications.ConclusionThis study has confirmed the observations of studies across Africa indicating the increasing use of medications during pregnancy. This is an indication that access to medicine is improving and more emphasis now must be placed on medication safety systems targeting pregnant women, especially during the first trimester when the risk of teratogenicity is highest.

AB - BackgroundThere is a paucity of epidemiological data on medication use in pregnancy in Cameroon.MethodsBetween March and August 2015, 795 pregnant women attending 8 urban and 12 rural hospitals in Cameroon for antenatal (ANC) or other care were interviewed on first trimester medication use using structured questionnaires. Multivariate logistic regression was used to analyse the association of 18 sociodemographic factors with medication use.ResultsA total of 582 (73.2%) women took at least one orthodox (Western) medication during the first trimester, 543 (68.3%) women a non-pregnancy related orthodox medication, and 336 (42.3%)women a pregnancy related orthodox medication. 44% of the women took anti-infectives including antimalarials (33.6%) and antibiotics (20.8%).The other most common medications were analgesics (48.8%) and antianaemias (38.6%). Sulfadoxine/pyrimethamine, contraindicated in the first trimester of pregnancy, was the most commonly used antimalarial(13% of women).0.2% of women reported antiretroviral use. Almost 80% of all orthodox medications consumed by women were purchased from the hospital. 12.8% of the women self-prescribed. Health unit and early gestational age at ANC booking were consistent determinants of prescribing of non-pregnancy related, pregnancy related and anti-infective medications. Illness and opinion on the safety of orthodox medications were determinants of the use of non-pregnancy related medications and anti-infectives. Age and parity were associated only with non-pregnancy related medications.ConclusionThis study has confirmed the observations of studies across Africa indicating the increasing use of medications during pregnancy. This is an indication that access to medicine is improving and more emphasis now must be placed on medication safety systems targeting pregnant women, especially during the first trimester when the risk of teratogenicity is highest.

KW - Medication

KW - pregnancy

KW - drug safety

KW - drug use

KW - pharmacoepidemiology

KW - determinants

KW - pharmacovigilance

KW - Cameroon

U2 - 10.1186/s12884-018-2081-x

DO - 10.1186/s12884-018-2081-x

M3 - Article

VL - 18

JO - BMC Pregnancy and Childbirth

T2 - BMC Pregnancy and Childbirth

JF - BMC Pregnancy and Childbirth

SN - 1471-2393

IS - 1

M1 - 450

ER -