Fabrication of flexible composite drug films via foldable linkages using electrohydrodynamic printing

Shuting Wu, Zeeshan Ahmad, Jing Song Li, Ming Wei Chang

    Research output: Contribution to journalArticle

    Abstract

    The simple method to manufacture a flexible multi-drug with hydrophilic and hydrophobic molecules-loaded composite membrane via three dimensional (3D) electrohydrodynamic (EHD) printing has been demonstrated in this study. The composite membrane consists of two different drug-loaded sections: cellulose acetate-ibuprofen (CA-IBU) and cellulose acetate-paracetamol (CA-Para), respectively, with an intermediate polycaprolactone (PCL) folding component. The composite membranes can be folded and housed in commercial capsules to aid swallowing. By changing the number of PCL layers in the intermediate layers, it is possible to control and modify the mechanical and unfolding properties of the composite membrane. IBU and Para are loaded into the CA polymeric matrix in their amorphous states, with the matrices exhibiting Higuchi and first order release kinetics, respectively. The combination of IBU and Para can potentially be used as analgesic for patients. Magnetic nanoparticles as a functional material can be incorporated into the PCL matrix for wide targeting and traceable applications. The composite membrane here possesses good biocompatibility and flexibility; enabling extensive application prospects in drug combination therapy and personalized medicine.

    LanguageEnglish
    Article number110393
    JournalMaterials Science and Engineering C
    Volume108
    Early online date5 Nov 2019
    DOIs
    Publication statusE-pub ahead of print - 5 Nov 2019

    Fingerprint

    Electrohydrodynamics
    electrohydrodynamics
    Composite membranes
    linkages
    printing
    Printing
    drugs
    Polycaprolactone
    membranes
    Fabrication
    fabrication
    composite materials
    Composite materials
    Pharmaceutical Preparations
    cellulose
    acetates
    Cellulose
    matrices
    Drug therapy
    Functional materials

    Keywords

    • 3D printing
    • Composite
    • Drug delivery
    • Folding

    Cite this

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    abstract = "The simple method to manufacture a flexible multi-drug with hydrophilic and hydrophobic molecules-loaded composite membrane via three dimensional (3D) electrohydrodynamic (EHD) printing has been demonstrated in this study. The composite membrane consists of two different drug-loaded sections: cellulose acetate-ibuprofen (CA-IBU) and cellulose acetate-paracetamol (CA-Para), respectively, with an intermediate polycaprolactone (PCL) folding component. The composite membranes can be folded and housed in commercial capsules to aid swallowing. By changing the number of PCL layers in the intermediate layers, it is possible to control and modify the mechanical and unfolding properties of the composite membrane. IBU and Para are loaded into the CA polymeric matrix in their amorphous states, with the matrices exhibiting Higuchi and first order release kinetics, respectively. The combination of IBU and Para can potentially be used as analgesic for patients. Magnetic nanoparticles as a functional material can be incorporated into the PCL matrix for wide targeting and traceable applications. The composite membrane here possesses good biocompatibility and flexibility; enabling extensive application prospects in drug combination therapy and personalized medicine.",
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    Fabrication of flexible composite drug films via foldable linkages using electrohydrodynamic printing. / Wu, Shuting; Ahmad, Zeeshan; Li, Jing Song; Chang, Ming Wei.

    In: Materials Science and Engineering C, Vol. 108, 110393, 01.03.2020.

    Research output: Contribution to journalArticle

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