FABRICATION OF BIOCOMPATIBLE NANO-CARBONATED HYDROXYAPATITE/POLYMER SPONGY SCAFFOLDS.

SA Siddiqi, U Azhar, F Manzoor, A Jamal, M Tariq, M Saleem, AA Chaudhry, IU Rehman

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
18 Downloads (Pure)

Abstract

Spongy scaffolds containing nano-carbonated hydroxyapatite (nCHA), with compositions Ca10(PO4)6-y(CO3)y(OH)2, with y=0,2,4, were prepared by the lyophilization method using different polymers such as natural gelatin (GE), chitosan (CS) and polyvinyl alcohol (PVA), alone or in their combinations. The samples were characterized by using XRD, SEM, and FTIR techniques. All the scaffolds were found to have porosities above 70% and their morphology changed significantly for one nCHA/polymer combination to the other. The nCHA containing scaffolds mediated cytotoxicity (MTT assay) and cell attachment studies were carried out on rat bone marrow derived mesenchymal stem cells
(rMSC). Evident cell attachment and no significant cytotoxicity was observed. The
preparation of spongy scaffolds and their biocompatibility augment their potential use in tissue engineering and biomedical applications.
Original languageEnglish
Pages (from-to)439-450
Number of pages12
JournalDigest Journal of Nanomaterials & Biostructures (DJNB)
Volume13
Issue number2
Early online dateJun 2018
Publication statusPublished online - Jun 2018

Keywords

  • Nano-carbonated hydroxyapatite
  • Spongy scaffolds
  • Mesenchymal stem cells
  • Hydroxyapatite/polymer scaffolds
  • MTT Assay
  • Biocompatability

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