Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers †

Claudio Curti; Michael N. Clifford; Colin D. Kay; Pedro Mena; Ana Rodriguez-Mateos; Daniele Del Rio; Gordon J. McDougall; Gary Williamson; Cristina Andres-Lacueva; Letizia Bresciani; Britt Burton Freeman; Aedin Cassidy; Yves Desjardin; Cesar G. Fraga; Chris. C. I. Gill; Paul A. Kroon; Nikolai Kuhnert; Iziar A. Ludwig; Claudine Manach; Dragan Milenkovic; Cláudia Nunes dos Santos; Patricia I. Oteiza; Gema Pereira-Caro; Francisco A. Tomás Barberán; David S. Wishart; Alan Crozier

doi:10.1039/d4fo06152g

Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers †

Claudio Curti
, Michael N. Clifford
, Colin D. Kay
, Pedro Mena
, Ana Rodriguez-Mateos
, Daniele Del Rio
, Gordon J. McDougall
, Gary Williamson
, Cristina Andres-Lacueva
, Letizia Bresciani
, Britt Burton Freeman
, Aedin Cassidy
, Yves Desjardin
, Cesar G. Fraga
, Chris. C. I. Gill
, Paul A. Kroon
, Nikolai Kuhnert
, Iziar A. Ludwig
, Claudine Manach
, Dragan Milenkovic

Cláudia Nunes dos Santos, Patricia I. Oteiza, Gema Pereira-Caro, Francisco A. Tomás Barberán, David S. Wishart, Alan Crozier

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

117 Downloads (Pure)

Abstract

There is an increasing body of evidence indicating that phenolic compounds derived from microbiota-mediated breakdown of dietary (poly)phenolics in the colon are at least partially responsible for the beneficial effects of a plant-based diet. Investigating the role of these catabolites and defining their particular biological effects is challenging due to the complex microbial pathways and the diversity of structures that are produced. When reviewing the data this is further exacerbated by the inconsistency and lack of standardization in naming the microbial phenolics. Here we update the nomenclature of colonic catabolites of dietary (poly)phenols, extending the proposals of Kay et al. (Am. J. Clin. Nutr., 2020, 112, 1051–1068, DOI: 10.1093/ajcn/nqaa204), by providing additional structures, and addressing the difficulties that can arise when investigating regioisomers and stereoisomers, where subtle differences in structure can have a substantial impact on bioactivity. The information provided will help to better harmonize the literature, facilitate data retrieval and provide a reference for researchers in several fields, especially nutrition and biochemistry.

Original language	English
Pages (from-to)	3963-4000
Number of pages	38
Journal	Food and Function
Volume	16
Issue number	10
Early online date	21 Apr 2025
DOIs	https://doi.org/10.1039/d4fo06152g
Publication status	Published (in print/issue) - 23 Apr 2025

Bibliographical note

Publisher Copyright:
© 2025 The Royal Society of Chemistry.

Data Availability Statement

Data files are available on requested from Alan Crozier at [email protected].

Funding

C. C. received financial support from the University of Parma. C. D. K. was funded by USDA-ARS project 6026-10700-001-000D. P. M. and D. D. R. were supported by the National Recovery and Resilience Plan of the Italian Ministry of University and Research funded by the European Union-NextGenerationEU; Award Number: PE00000003 \u201CON Foods \u2013 Research and innovation network on Food and Nutrition, Sustainability, Safety and Security \u2013 Working ON Foods\u201D. G. M. D. was supported by the Rural & Environment Science & Analytical Services Division of the Scottish Government\u201D A. C., G. P.-C. and C. I. R. G. were funded by the Distinguished Scientist Fellowship Program (DSFP) of King Saud University, Riyadh, Saudi Arabia.

Funders	Funder number
Scottish Government
King Saud University
6026-10700-001-000D
PE00000003
European Commission	PE00000003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gastrointestinal Microbiome
Humans
Terminology as Topic
Polyphenols/metabolism
Isomerism
Phenols/metabolism
Diet
Colon/microbiology
Bacteria/metabolism

Access to Document

10.1039/d4fo06152g

D4FO06152G.pdfFinal published version, 9.57 MBLicence: CC BY

Cite this

Curti, C., Clifford, M. N., Kay, C. D., Mena, P., Rodriguez-Mateos, A., Del Rio, D., McDougall, G. J., Williamson, G., Andres-Lacueva, C., Bresciani, L., Burton Freeman, B., Cassidy, A., Desjardin, Y., Fraga, C. G., Gill, C. C. I., Kroon, P. A., Kuhnert, N., Ludwig, I. A., Manach, C., ... Crozier, A. (2025). Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers †. Food and Function, 16(10), 3963-4000. https://doi.org/10.1039/d4fo06152g

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title = "Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers †",

abstract = "There is an increasing body of evidence indicating that phenolic compounds derived from microbiota-mediated breakdown of dietary (poly)phenolics in the colon are at least partially responsible for the beneficial effects of a plant-based diet. Investigating the role of these catabolites and defining their particular biological effects is challenging due to the complex microbial pathways and the diversity of structures that are produced. When reviewing the data this is further exacerbated by the inconsistency and lack of standardization in naming the microbial phenolics. Here we update the nomenclature of colonic catabolites of dietary (poly)phenols, extending the proposals of Kay et al. (Am. J. Clin. Nutr., 2020, 112, 1051–1068, DOI: 10.1093/ajcn/nqaa204), by providing additional structures, and addressing the difficulties that can arise when investigating regioisomers and stereoisomers, where subtle differences in structure can have a substantial impact on bioactivity. The information provided will help to better harmonize the literature, facilitate data retrieval and provide a reference for researchers in several fields, especially nutrition and biochemistry. ",

keywords = "Gastrointestinal Microbiome, Humans, Terminology as Topic, Polyphenols/metabolism, Isomerism, Phenols/metabolism, Diet, Colon/microbiology, Bacteria/metabolism",

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doi = "10.1039/d4fo06152g",

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volume = "16",

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Curti, C, Clifford, MN, Kay, CD, Mena, P, Rodriguez-Mateos, A, Del Rio, D, McDougall, GJ, Williamson, G, Andres-Lacueva, C, Bresciani, L, Burton Freeman, B, Cassidy, A, Desjardin, Y, Fraga, CG, Gill, CCI, Kroon, PA, Kuhnert, N, Ludwig, IA, Manach, C, Milenkovic, D, Nunes dos Santos, C, Oteiza, PI, Pereira-Caro, G, Tomás Barberán, FA, Wishart, DS & Crozier, A 2025, 'Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers †', Food and Function, vol. 16, no. 10, pp. 3963-4000. https://doi.org/10.1039/d4fo06152g

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AU - Curti, Claudio

AU - Clifford, Michael N.

AU - Kay, Colin D.

AU - Mena, Pedro

AU - Rodriguez-Mateos, Ana

AU - Del Rio, Daniele

AU - McDougall, Gordon J.

AU - Williamson, Gary

AU - Andres-Lacueva, Cristina

AU - Bresciani, Letizia

AU - Burton Freeman, Britt

AU - Cassidy, Aedin

AU - Desjardin, Yves

AU - Fraga, Cesar G.

AU - Gill, Chris. C. I.

AU - Kroon, Paul A.

AU - Kuhnert, Nikolai

AU - Ludwig, Iziar A.

AU - Manach, Claudine

AU - Milenkovic, Dragan

AU - Nunes dos Santos, Cláudia

AU - Oteiza, Patricia I.

AU - Pereira-Caro, Gema

AU - Tomás Barberán, Francisco A.

AU - Wishart, David S.

AU - Crozier, Alan

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N2 - There is an increasing body of evidence indicating that phenolic compounds derived from microbiota-mediated breakdown of dietary (poly)phenolics in the colon are at least partially responsible for the beneficial effects of a plant-based diet. Investigating the role of these catabolites and defining their particular biological effects is challenging due to the complex microbial pathways and the diversity of structures that are produced. When reviewing the data this is further exacerbated by the inconsistency and lack of standardization in naming the microbial phenolics. Here we update the nomenclature of colonic catabolites of dietary (poly)phenols, extending the proposals of Kay et al. (Am. J. Clin. Nutr., 2020, 112, 1051–1068, DOI: 10.1093/ajcn/nqaa204), by providing additional structures, and addressing the difficulties that can arise when investigating regioisomers and stereoisomers, where subtle differences in structure can have a substantial impact on bioactivity. The information provided will help to better harmonize the literature, facilitate data retrieval and provide a reference for researchers in several fields, especially nutrition and biochemistry.

AB - There is an increasing body of evidence indicating that phenolic compounds derived from microbiota-mediated breakdown of dietary (poly)phenolics in the colon are at least partially responsible for the beneficial effects of a plant-based diet. Investigating the role of these catabolites and defining their particular biological effects is challenging due to the complex microbial pathways and the diversity of structures that are produced. When reviewing the data this is further exacerbated by the inconsistency and lack of standardization in naming the microbial phenolics. Here we update the nomenclature of colonic catabolites of dietary (poly)phenols, extending the proposals of Kay et al. (Am. J. Clin. Nutr., 2020, 112, 1051–1068, DOI: 10.1093/ajcn/nqaa204), by providing additional structures, and addressing the difficulties that can arise when investigating regioisomers and stereoisomers, where subtle differences in structure can have a substantial impact on bioactivity. The information provided will help to better harmonize the literature, facilitate data retrieval and provide a reference for researchers in several fields, especially nutrition and biochemistry.

KW - Gastrointestinal Microbiome

KW - Humans

KW - Terminology as Topic

KW - Polyphenols/metabolism

KW - Isomerism

KW - Phenols/metabolism

KW - Diet

KW - Colon/microbiology

KW - Bacteria/metabolism

UR - https://pure.ulster.ac.uk/en/publications/dd16e6bf-2ff6-4884-bcf8-549810be9af1

UR - https://www.scopus.com/pages/publications/105003091940

U2 - 10.1039/d4fo06152g

DO - 10.1039/d4fo06152g

M3 - Article

C2 - 40264252

SN - 2042-6496

VL - 16

SP - 3963

EP - 4000

JO - Food and Function

JF - Food and Function

IS - 10

ER -

Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers †

Abstract

Bibliographical note

Data Availability Statement

Funding

UN SDGs

Keywords

Access to Document

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