Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon

Hamid A. Bakshi, Gerry A. Quinn, Alaa A. A. Aljabali, Faruck L. Hakkim, Rabia Farzand, Mohamed M. Nasef, Naji Abuglela, Prawej Ansari, Vijay Mishra, Ángel Serrano-Aroca, Murtaza M. Tambuwala

Research output: Contribution to journalReview articlepeer-review

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Abstract

The prevalence of colon-associated diseases has increased significantly over the past several decades, as evidenced by accumulated literature on conditions such as Crohn’s disease, irritable bowel syndrome, colorectal cancer, and ulcerative colitis. Developing therapeutics for these diseases is challenging due to physiological barriers of the colon, systemic side effects, and the intestinal environment. Therefore, in a search for novel methods to overcome some of these problems, researchers discovered that microbial metabolism by gut microbiotia offers a potential method for targeted drug delivery This overview highlights several drug delivery systems used to modulate the microbiota and improve colon-targeted drug delivery. This technology will be important in developing a new generation of therapies which harness the metabolism of the human gut microflora.
Original languageEnglish
Article number1211
Pages (from-to)1-14
Number of pages14
JournalPharmaceuticals
Volume14
Issue number12
Early online date23 Nov 2021
DOIs
Publication statusPublished - 31 Dec 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • colon
  • gut microflora
  • oral drug delivery
  • gastrointestinal technology
  • genetically modified bacteria
  • probiotics
  • gut metabolism
  • colon targeted delivery

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