Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2

Chithravel Vadivalagan, Anushka Shitut, Siva Kamalakannan, Ruei-ming Chen, Ángel Serrano-aroca, Vijay Mishra, Alaa A.a. Aljabali, Sachin Kumar Singh, Dinesh Kumar Chellappan, Gaurav Gupta, Kamal Dua, Mohamed El-Tanani, Murtaza M. Tambuwala, Anand Krishnan

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Abstract

Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic positions, and single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation. Several vaccines were developed and in treatment practice, but effective control has yet to reach in cent presence. It was initially a narrow immune-modulating protein target. Controlling these diverse viral strains may inhibit their transuding mechanisms primarily to target RNA genes responsible for COVID19 transcription. Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription. This review discussed targeted viral transcription by delivering the artificial miRNA (amiRNA) mediated exosomes in the infected cells and significant resources of exosome and their efficacy.
Original languageEnglish
Article number110334
Pages (from-to)1-11
Number of pages11
JournalCellular Signalling
Volume95
Early online date21 Apr 2022
DOIs
Publication statusE-pub ahead of print - 21 Apr 2022

Bibliographical note

Copyright © 2021. Published by Elsevier Inc.

Keywords

  • Artificial miRNA
  • Exosomes
  • Transcription
  • Inhibition
  • COVID19 mutant

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