TY - JOUR
T1 - Exosomal mediated signal transduction through artificial microRNA (amiRNA)
T2 - A potential target for inhibition of SARS-CoV-2
AU - Vadivalagan, Chithravel
AU - Shitut, Anushka
AU - Kamalakannan, Siva
AU - Chen, Ruei-ming
AU - Serrano-aroca, Ángel
AU - Mishra, Vijay
AU - Aljabali, Alaa A.a.
AU - Singh, Sachin Kumar
AU - Chellappan, Dinesh Kumar
AU - Gupta, Gaurav
AU - Dua, Kamal
AU - El-Tanani, Mohamed
AU - Tambuwala, Murtaza M.
AU - Krishnan, Anand
N1 - Copyright © 2021. Published by Elsevier Inc.
PY - 2022/7/22
Y1 - 2022/7/22
N2 - Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic positions, and single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation. Several vaccines were developed and in treatment practice, but effective control has yet to reach in cent presence. It was initially a narrow immune-modulating protein target. Controlling these diverse viral strains may inhibit their transuding mechanisms primarily to target RNA genes responsible for COVID19 transcription. Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription. This review discussed targeted viral transcription by delivering the artificial miRNA (amiRNA) mediated exosomes in the infected cells and significant resources of exosome and their efficacy.
AB - Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic positions, and single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation. Several vaccines were developed and in treatment practice, but effective control has yet to reach in cent presence. It was initially a narrow immune-modulating protein target. Controlling these diverse viral strains may inhibit their transuding mechanisms primarily to target RNA genes responsible for COVID19 transcription. Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription. This review discussed targeted viral transcription by delivering the artificial miRNA (amiRNA) mediated exosomes in the infected cells and significant resources of exosome and their efficacy.
KW - Artificial miRNA
KW - Exosomes
KW - Transcription
KW - Inhibition
KW - COVID19 mutant
UR - https://linkinghub.elsevier.com/retrieve/pii/S089865682200095X
UR - https://pubmed.ncbi.nlm.nih.gov/35461900/
UR - http://www.scopus.com/inward/record.url?scp=85129515922&partnerID=8YFLogxK
U2 - 10.1016/j.cellsig.2022.110334
DO - 10.1016/j.cellsig.2022.110334
M3 - Article
C2 - 35461900
SN - 0898-6568
VL - 95
SP - 1
EP - 11
JO - Cellular Signalling
JF - Cellular Signalling
M1 - 110334
ER -
