Exogenous leptin influences gastrointestinal growth and in vitro small intestinal motility in neonatal piglets - preliminary results

J Wolinski, Violetta Naughton (nee Lesniewska), M Biernat, M Babelewska, W Korczyniski, R Zabielski

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Eight newborn piglets were randomly assigned to two groups. All of the piglets were fed with a milk replacer using an ``artificial sow''. Three limes daily for six days they received physiological saline (0.9% NaCl) (control group, n=5) or leptin at 10 mug/kg body weight dissolved in physiological saline (experimental group, n=3) administered intragastrically. The piglets were then anaethesized, the entire gastrointestinal tract removed, and fragments of the duodenum and mid-jejunum were harvested and their in vitro motility was measured. Despite lack of differences in body weight, the piglets treated with leptin showed differences in the weight of the stomach and pancreas and length of the ileum in comparison with the controls. Administration of leptin also significantly affected intestinal motility in a manner characteristic of the particular segments (P <0.05; P <0.01; P <0.001, respectively). The spontaneous contractions of the duodenum and its response to acetylcholine and isoproterenol were higher in the group of piglets treated with leptin than in controls, whereas segments of the jejunum behaved in the opposite manner. The experiments will be continued in order to confirm these results on a larger number of animals.
LanguageEnglish
Pages249-254
JournalJournal of Animal and Feed Sciences
Volume10
Issue numberSuppl.
Publication statusPublished - 2001

Fingerprint

gastrointestinal motility
Gastrointestinal Motility
Leptin
leptin
piglets
Jejunum
Growth
Duodenum
Citrus aurantiifolia
jejunum
duodenum
Body Weight
Ileum
Isoproterenol
milk replacer
body weight
Acetylcholine
Gastrointestinal Tract
Pancreas
acetylcholine

Keywords

  • contractile activity
  • duodenum
  • acetylcholine
  • development
  • piglets

Cite this

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title = "Exogenous leptin influences gastrointestinal growth and in vitro small intestinal motility in neonatal piglets - preliminary results",
abstract = "Eight newborn piglets were randomly assigned to two groups. All of the piglets were fed with a milk replacer using an ``artificial sow''. Three limes daily for six days they received physiological saline (0.9{\%} NaCl) (control group, n=5) or leptin at 10 mug/kg body weight dissolved in physiological saline (experimental group, n=3) administered intragastrically. The piglets were then anaethesized, the entire gastrointestinal tract removed, and fragments of the duodenum and mid-jejunum were harvested and their in vitro motility was measured. Despite lack of differences in body weight, the piglets treated with leptin showed differences in the weight of the stomach and pancreas and length of the ileum in comparison with the controls. Administration of leptin also significantly affected intestinal motility in a manner characteristic of the particular segments (P <0.05; P <0.01; P <0.001, respectively). The spontaneous contractions of the duodenum and its response to acetylcholine and isoproterenol were higher in the group of piglets treated with leptin than in controls, whereas segments of the jejunum behaved in the opposite manner. The experiments will be continued in order to confirm these results on a larger number of animals.",
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Exogenous leptin influences gastrointestinal growth and in vitro small intestinal motility in neonatal piglets - preliminary results. / Wolinski, J; Naughton (nee Lesniewska), Violetta; Biernat, M; Babelewska, M; Korczyniski, W; Zabielski, R.

In: Journal of Animal and Feed Sciences, Vol. 10, No. Suppl., 2001, p. 249-254.

Research output: Contribution to journalArticle

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AU - Wolinski, J

AU - Naughton (nee Lesniewska), Violetta

AU - Biernat, M

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AU - Korczyniski, W

AU - Zabielski, R

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