Existence of the rs7041 Polymorphism in the Vitamin D Binding Protein Gene Among Bangladeshis with Low Serum Vitamin D: A Pilot Study

Ridwana Rahman; Kazi Lutfar Rahman; Imtiaz Pervez; Sudipta Sarker; Md Sayedur Rahman; Peter A C McPherson; Qazi Shamima Akhter

doi:10.1016/j.nexres.2025.100570

Existence of the rs7041 Polymorphism in the Vitamin D Binding Protein Gene Among Bangladeshis with Low Serum Vitamin D: A Pilot Study

Ridwana Rahman
, Kazi Lutfar Rahman
, Imtiaz Pervez
, Sudipta Sarker
, Md Sayedur Rahman
, Peter A C McPherson
, Qazi Shamima Akhter

Research output: Contribution to journal › Article › peer-review

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Abstract

Low serum vitamin D can be attributed to single nucleotide polymorphisms in the group specific component gene. This pilot study seeks to identify the frequency of the main variants of the rs7041 polymorphism in a sample of adult Bangladeshis with low vitamin D. This cross-sectional study was conducted at Dhaka Medical College among individuals exposed to abundant sunlight. Thirty-two individuals with low serum vitamin D were enlisted in the study. Ten individuals having normal serum vitamin D were taken as a control for comparison. Biochemical measurements and genotype analysis were performed for both groups. Among those with low serum vitamin D level, the frequency of the TT genotype was statistically lower than the TG and GG genotype (p < 0.05). Further comparison showed that the serum vitamin D level in TT individuals was statistically lower than those expressing the TG genotype (p < 0.05). Among controls, differences in the serum vitamin D level in three genotypes TT, TG, and GG were not statistically significant. Overall, this pilot study has shown that the TG and TT genotypes of rs7041 in the group specific component gene are significantly related to low serum vitamin D in Bangladeshi adults. Future studies with a larger sample size will be needed to establish the case for widespread vitamin D supplementation in Bangladeshi adults.

Original language	English
Article number	100570
Pages (from-to)	1-6
Number of pages	6
Journal	Next Research
Volume	2
Issue number	3
Early online date	10 Jul 2025
DOIs	https://doi.org/10.1016/j.nexres.2025.100570
Publication status	Published (in print/issue) - 30 Sept 2025

Data Access Statement

The data generated and/or analysed during the current study,
including gene analysis results, are not publicly available due to the
inclusion of sensitive and confidential patient information. However, the data (including Excel and SPSS files, as well as scanned copies of
written informed consent forms) can be made available upon reasonable request to the corresponding author, specifically for review purposes or for validation by authorized reviewers, in accordance with ethical guidelines.

Keywords

Genotyping
hypovitaminosis D
Rs7041
single nucleotide polymorphism
Vitamin D binding protein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nexres.2025.100570

1-s2.0-S3050475925004397-mainFinal published version, 1.35 MBLicence: CC BY

Cite this

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title = "Existence of the rs7041 Polymorphism in the Vitamin D Binding Protein Gene Among Bangladeshis with Low Serum Vitamin D: A Pilot Study",

abstract = "Low serum vitamin D can be attributed to single nucleotide polymorphisms in the group specific component gene. This pilot study seeks to identify the frequency of the main variants of the rs7041 polymorphism in a sample of adult Bangladeshis with low vitamin D. This cross-sectional study was conducted at Dhaka Medical College among individuals exposed to abundant sunlight. Thirty-two individuals with low serum vitamin D were enlisted in the study. Ten individuals having normal serum vitamin D were taken as a control for comparison. Biochemical measurements and genotype analysis were performed for both groups. Among those with low serum vitamin D level, the frequency of the TT genotype was statistically lower than the TG and GG genotype (p < 0.05). Further comparison showed that the serum vitamin D level in TT individuals was statistically lower than those expressing the TG genotype (p < 0.05). Among controls, differences in the serum vitamin D level in three genotypes TT, TG, and GG were not statistically significant. Overall, this pilot study has shown that the TG and TT genotypes of rs7041 in the group specific component gene are significantly related to low serum vitamin D in Bangladeshi adults. Future studies with a larger sample size will be needed to establish the case for widespread vitamin D supplementation in Bangladeshi adults.",

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AU - Sarker, Sudipta

AU - Rahman, Md Sayedur

AU - McPherson, Peter A C

AU - Akhter, Qazi Shamima

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N2 - Low serum vitamin D can be attributed to single nucleotide polymorphisms in the group specific component gene. This pilot study seeks to identify the frequency of the main variants of the rs7041 polymorphism in a sample of adult Bangladeshis with low vitamin D. This cross-sectional study was conducted at Dhaka Medical College among individuals exposed to abundant sunlight. Thirty-two individuals with low serum vitamin D were enlisted in the study. Ten individuals having normal serum vitamin D were taken as a control for comparison. Biochemical measurements and genotype analysis were performed for both groups. Among those with low serum vitamin D level, the frequency of the TT genotype was statistically lower than the TG and GG genotype (p < 0.05). Further comparison showed that the serum vitamin D level in TT individuals was statistically lower than those expressing the TG genotype (p < 0.05). Among controls, differences in the serum vitamin D level in three genotypes TT, TG, and GG were not statistically significant. Overall, this pilot study has shown that the TG and TT genotypes of rs7041 in the group specific component gene are significantly related to low serum vitamin D in Bangladeshi adults. Future studies with a larger sample size will be needed to establish the case for widespread vitamin D supplementation in Bangladeshi adults.

AB - Low serum vitamin D can be attributed to single nucleotide polymorphisms in the group specific component gene. This pilot study seeks to identify the frequency of the main variants of the rs7041 polymorphism in a sample of adult Bangladeshis with low vitamin D. This cross-sectional study was conducted at Dhaka Medical College among individuals exposed to abundant sunlight. Thirty-two individuals with low serum vitamin D were enlisted in the study. Ten individuals having normal serum vitamin D were taken as a control for comparison. Biochemical measurements and genotype analysis were performed for both groups. Among those with low serum vitamin D level, the frequency of the TT genotype was statistically lower than the TG and GG genotype (p < 0.05). Further comparison showed that the serum vitamin D level in TT individuals was statistically lower than those expressing the TG genotype (p < 0.05). Among controls, differences in the serum vitamin D level in three genotypes TT, TG, and GG were not statistically significant. Overall, this pilot study has shown that the TG and TT genotypes of rs7041 in the group specific component gene are significantly related to low serum vitamin D in Bangladeshi adults. Future studies with a larger sample size will be needed to establish the case for widespread vitamin D supplementation in Bangladeshi adults.

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Existence of the rs7041 Polymorphism in the Vitamin D Binding Protein Gene Among Bangladeshis with Low Serum Vitamin D: A Pilot Study

Abstract

Data Access Statement

Keywords

UN SDGs

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