Exercise training and impaired glucose tolerance in obese humans

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Individuals with impaired glucose tolerance (IGT) are at greater risk of developing diabetes than in normoglycaemia. Theaim of this study was to examine the effects of 12-weeks exercise training in obese humans with IGT. Eleven participants (6males and 5 females; 49+9 years; mean Body Mass Index (BMI) 32.4 kg m72), completed a 12-week brisk walkingintervention (30 min per day, five days a week (d wk71), at 65% of age-predicted maximal heart rate (HRmax).Anthropometric measurements, dietary intake, pulse wave velocity (PWV, to determine arterial stiffness) and blood pressure(BP) were examined at baseline and post intervention. Fasting blood glucose, glycosylated haemoglobin, insulin, bloodlipids, indices of oxidative stress and inflammation (lipid hydroperoxides; superoxide dismutase; multimeric adiponectinconcentration and high-sensitivity C-reactive protein) were also determined. Post intervention, PWV (9.08+1.27 m s71 vs.8.39+1.21 m s71), systolic BP (145.4+14.5 vs. 135.8+14.9 mmHg), triglycerides (1.52+0.53 mmol . L71 vs.1.31+0.54 mmol . L71), lipid hydroperoxides (1.20+0.47 mM L71 vs. 0.79+0.32 mM L71) and anthropometricmeasures decreased significantly (P50.05). Moderate intensity exercise training improves upper limb vascular function inobese humans with IGT, possibly by improving triglyceride metabolism, which may subsequently reduce oxidative stress.These changes were independent of multimeric adiponectin modification and alterations in other blood biomarkers.
LanguageEnglish
Pages725-732
JournalJournal of Sports Sciences
Volume30
Issue number8
DOIs
Publication statusPublished - 1 Apr 2012

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Glucose Intolerance
Lipid Peroxides
Exercise
Triglycerides
Oxidative Stress
Blood Pressure
Pulse Wave Analysis
Vascular Stiffness
Adiponectin
Glycosylated Hemoglobin A
Upper Extremity
C-Reactive Protein
Superoxide Dismutase
Blood Vessels
Blood Glucose
Fasting
Arterial Pressure
Body Mass Index
Biomarkers
Heart Rate

Keywords

  • exercise
  • arterial stiffness
  • cardiovascular risk
  • obesity

Cite this

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title = "Exercise training and impaired glucose tolerance in obese humans",
abstract = "Individuals with impaired glucose tolerance (IGT) are at greater risk of developing diabetes than in normoglycaemia. Theaim of this study was to examine the effects of 12-weeks exercise training in obese humans with IGT. Eleven participants (6males and 5 females; 49+9 years; mean Body Mass Index (BMI) 32.4 kg m72), completed a 12-week brisk walkingintervention (30 min per day, five days a week (d wk71), at 65{\%} of age-predicted maximal heart rate (HRmax).Anthropometric measurements, dietary intake, pulse wave velocity (PWV, to determine arterial stiffness) and blood pressure(BP) were examined at baseline and post intervention. Fasting blood glucose, glycosylated haemoglobin, insulin, bloodlipids, indices of oxidative stress and inflammation (lipid hydroperoxides; superoxide dismutase; multimeric adiponectinconcentration and high-sensitivity C-reactive protein) were also determined. Post intervention, PWV (9.08+1.27 m s71 vs.8.39+1.21 m s71), systolic BP (145.4+14.5 vs. 135.8+14.9 mmHg), triglycerides (1.52+0.53 mmol . L71 vs.1.31+0.54 mmol . L71), lipid hydroperoxides (1.20+0.47 mM L71 vs. 0.79+0.32 mM L71) and anthropometricmeasures decreased significantly (P50.05). Moderate intensity exercise training improves upper limb vascular function inobese humans with IGT, possibly by improving triglyceride metabolism, which may subsequently reduce oxidative stress.These changes were independent of multimeric adiponectin modification and alterations in other blood biomarkers.",
keywords = "exercise, arterial stiffness, cardiovascular risk, obesity",
author = "Andrea McNeilly and Conor McClean and Marie Murphy and Jane McEneny and Tom Trinick and George Burke and Ellie Duly and James McLaughlin and Gareth Davison",
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Exercise training and impaired glucose tolerance in obese humans. / McNeilly, Andrea; McClean, Conor; Murphy, Marie; McEneny, Jane; Trinick, Tom; Burke, George; Duly, Ellie; McLaughlin, James; Davison, Gareth.

In: Journal of Sports Sciences, Vol. 30, No. 8, 01.04.2012, p. 725-732.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Exercise training and impaired glucose tolerance in obese humans

AU - McNeilly, Andrea

AU - McClean, Conor

AU - Murphy, Marie

AU - McEneny, Jane

AU - Trinick, Tom

AU - Burke, George

AU - Duly, Ellie

AU - McLaughlin, James

AU - Davison, Gareth

PY - 2012/4/1

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N2 - Individuals with impaired glucose tolerance (IGT) are at greater risk of developing diabetes than in normoglycaemia. Theaim of this study was to examine the effects of 12-weeks exercise training in obese humans with IGT. Eleven participants (6males and 5 females; 49+9 years; mean Body Mass Index (BMI) 32.4 kg m72), completed a 12-week brisk walkingintervention (30 min per day, five days a week (d wk71), at 65% of age-predicted maximal heart rate (HRmax).Anthropometric measurements, dietary intake, pulse wave velocity (PWV, to determine arterial stiffness) and blood pressure(BP) were examined at baseline and post intervention. Fasting blood glucose, glycosylated haemoglobin, insulin, bloodlipids, indices of oxidative stress and inflammation (lipid hydroperoxides; superoxide dismutase; multimeric adiponectinconcentration and high-sensitivity C-reactive protein) were also determined. Post intervention, PWV (9.08+1.27 m s71 vs.8.39+1.21 m s71), systolic BP (145.4+14.5 vs. 135.8+14.9 mmHg), triglycerides (1.52+0.53 mmol . L71 vs.1.31+0.54 mmol . L71), lipid hydroperoxides (1.20+0.47 mM L71 vs. 0.79+0.32 mM L71) and anthropometricmeasures decreased significantly (P50.05). Moderate intensity exercise training improves upper limb vascular function inobese humans with IGT, possibly by improving triglyceride metabolism, which may subsequently reduce oxidative stress.These changes were independent of multimeric adiponectin modification and alterations in other blood biomarkers.

AB - Individuals with impaired glucose tolerance (IGT) are at greater risk of developing diabetes than in normoglycaemia. Theaim of this study was to examine the effects of 12-weeks exercise training in obese humans with IGT. Eleven participants (6males and 5 females; 49+9 years; mean Body Mass Index (BMI) 32.4 kg m72), completed a 12-week brisk walkingintervention (30 min per day, five days a week (d wk71), at 65% of age-predicted maximal heart rate (HRmax).Anthropometric measurements, dietary intake, pulse wave velocity (PWV, to determine arterial stiffness) and blood pressure(BP) were examined at baseline and post intervention. Fasting blood glucose, glycosylated haemoglobin, insulin, bloodlipids, indices of oxidative stress and inflammation (lipid hydroperoxides; superoxide dismutase; multimeric adiponectinconcentration and high-sensitivity C-reactive protein) were also determined. Post intervention, PWV (9.08+1.27 m s71 vs.8.39+1.21 m s71), systolic BP (145.4+14.5 vs. 135.8+14.9 mmHg), triglycerides (1.52+0.53 mmol . L71 vs.1.31+0.54 mmol . L71), lipid hydroperoxides (1.20+0.47 mM L71 vs. 0.79+0.32 mM L71) and anthropometricmeasures decreased significantly (P50.05). Moderate intensity exercise training improves upper limb vascular function inobese humans with IGT, possibly by improving triglyceride metabolism, which may subsequently reduce oxidative stress.These changes were independent of multimeric adiponectin modification and alterations in other blood biomarkers.

KW - exercise

KW - arterial stiffness

KW - cardiovascular risk

KW - obesity

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DO - 10.1080/02640414.2012.671952

M3 - Article

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SP - 725

EP - 732

JO - Journal of Sports Sciences

T2 - Journal of Sports Sciences

JF - Journal of Sports Sciences

SN - 0264-0414

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ER -