Exercise and nutrition interventions in advanced lung cancer: a systematic review

Catherine Payne, Philip J Larkin, Sonja J McIlfatrick, Lynn Dunwoody, Jackie H Gracey

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

ABSTRACTIn this systematic review, we sought to evaluate the effect of physical activity or nutrition interventions (or both) in adults with advanced non-small-cell lung cancer (NSCLC).MethodsA systematic search for relevant clinical trials was conducted in 6 electronic databases, by hand searching, and by contacting key investigators. No limits were placed on study language. Information about recruitment rates, protocol adherence, patient-reported and clinical outcome measures, and study conclusions was extracted. Methodologic quality and risk of bias in each study was assessed using validated tools.Main ResultsSix papers detailing five studies involving 203 participants met the inclusion criteria. Two of the studies were single-cohort physical activity studies (54 participants), and three were controlled nutrition studies (149 participants). All were conducted in an outpatient setting. None of the included studies combined physical activity with nutrition interventions.ConclusionsOur systematic review suggests that exercise and nutrition interventions are not harmful and may have beneficial effects on unintentional weight loss, physical strength, and functional performance in patients with advanced NSCLC. However, the observed improvements must be interpreted with caution, because findings were not consistent across the included studies. Moreover, the included studies were small and at significant risk of bias.More research is required to ascertain the optimal physical activity and nutrition interventions in advanced inoperable NSCLC. Specifically, the potential benefits of combining physical activity with nutrition counselling have yet to be adequately explored in this population.
LanguageEnglish
Pagese321-e337
JournalCurrent Oncology
Volume20
Issue number4
Publication statusPublished - Aug 2013

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Lung Neoplasms
Exercise
Non-Small Cell Lung Carcinoma
Counseling
Weight Loss
Outpatients
Language
Research Personnel
Outcome Assessment (Health Care)
Clinical Trials
Databases
Research
Population

Keywords

  • Palliation
  • rehabilitation
  • systematic review
  • lungs
  • exercise
  • nutrition

Cite this

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abstract = "ABSTRACTIn this systematic review, we sought to evaluate the effect of physical activity or nutrition interventions (or both) in adults with advanced non-small-cell lung cancer (NSCLC).MethodsA systematic search for relevant clinical trials was conducted in 6 electronic databases, by hand searching, and by contacting key investigators. No limits were placed on study language. Information about recruitment rates, protocol adherence, patient-reported and clinical outcome measures, and study conclusions was extracted. Methodologic quality and risk of bias in each study was assessed using validated tools.Main ResultsSix papers detailing five studies involving 203 participants met the inclusion criteria. Two of the studies were single-cohort physical activity studies (54 participants), and three were controlled nutrition studies (149 participants). All were conducted in an outpatient setting. None of the included studies combined physical activity with nutrition interventions.ConclusionsOur systematic review suggests that exercise and nutrition interventions are not harmful and may have beneficial effects on unintentional weight loss, physical strength, and functional performance in patients with advanced NSCLC. However, the observed improvements must be interpreted with caution, because findings were not consistent across the included studies. Moreover, the included studies were small and at significant risk of bias.More research is required to ascertain the optimal physical activity and nutrition interventions in advanced inoperable NSCLC. Specifically, the potential benefits of combining physical activity with nutrition counselling have yet to be adequately explored in this population.",
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Exercise and nutrition interventions in advanced lung cancer: a systematic review. / Payne, Catherine; Larkin, Philip J; McIlfatrick, Sonja J; Dunwoody, Lynn; Gracey, Jackie H.

Vol. 20, No. 4, 08.2013, p. e321-e337.

Research output: Contribution to journalArticle

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T1 - Exercise and nutrition interventions in advanced lung cancer: a systematic review

AU - Payne, Catherine

AU - Larkin, Philip J

AU - McIlfatrick, Sonja J

AU - Dunwoody, Lynn

AU - Gracey, Jackie H

PY - 2013/8

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N2 - ABSTRACTIn this systematic review, we sought to evaluate the effect of physical activity or nutrition interventions (or both) in adults with advanced non-small-cell lung cancer (NSCLC).MethodsA systematic search for relevant clinical trials was conducted in 6 electronic databases, by hand searching, and by contacting key investigators. No limits were placed on study language. Information about recruitment rates, protocol adherence, patient-reported and clinical outcome measures, and study conclusions was extracted. Methodologic quality and risk of bias in each study was assessed using validated tools.Main ResultsSix papers detailing five studies involving 203 participants met the inclusion criteria. Two of the studies were single-cohort physical activity studies (54 participants), and three were controlled nutrition studies (149 participants). All were conducted in an outpatient setting. None of the included studies combined physical activity with nutrition interventions.ConclusionsOur systematic review suggests that exercise and nutrition interventions are not harmful and may have beneficial effects on unintentional weight loss, physical strength, and functional performance in patients with advanced NSCLC. However, the observed improvements must be interpreted with caution, because findings were not consistent across the included studies. Moreover, the included studies were small and at significant risk of bias.More research is required to ascertain the optimal physical activity and nutrition interventions in advanced inoperable NSCLC. Specifically, the potential benefits of combining physical activity with nutrition counselling have yet to be adequately explored in this population.

AB - ABSTRACTIn this systematic review, we sought to evaluate the effect of physical activity or nutrition interventions (or both) in adults with advanced non-small-cell lung cancer (NSCLC).MethodsA systematic search for relevant clinical trials was conducted in 6 electronic databases, by hand searching, and by contacting key investigators. No limits were placed on study language. Information about recruitment rates, protocol adherence, patient-reported and clinical outcome measures, and study conclusions was extracted. Methodologic quality and risk of bias in each study was assessed using validated tools.Main ResultsSix papers detailing five studies involving 203 participants met the inclusion criteria. Two of the studies were single-cohort physical activity studies (54 participants), and three were controlled nutrition studies (149 participants). All were conducted in an outpatient setting. None of the included studies combined physical activity with nutrition interventions.ConclusionsOur systematic review suggests that exercise and nutrition interventions are not harmful and may have beneficial effects on unintentional weight loss, physical strength, and functional performance in patients with advanced NSCLC. However, the observed improvements must be interpreted with caution, because findings were not consistent across the included studies. Moreover, the included studies were small and at significant risk of bias.More research is required to ascertain the optimal physical activity and nutrition interventions in advanced inoperable NSCLC. Specifically, the potential benefits of combining physical activity with nutrition counselling have yet to be adequately explored in this population.

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