Exercise and Cardiovascular Health in the UAE

Gareth Davison, Sarah Dalibalta

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Exercise and physical activity are fundamental in the prevention and treatment of chronic diseases such as cardiovascular disease (CVD). The underlying mechanisms through which exercise in particular can mediate its effects have been well studied and include, but is not limited to, changes in the vascular nitric oxide pathway, leading to a reduction in pathological vasoconstriction and enhanced endothelial function. The harmful effects of many risk factors for CVD such as hypertension, dyslipidaemia, insulin resistance and obesity, can be mitigated by regular exercise. The majority of the UAE adult population currently are sedentary, and perhaps even more noteworthy is that only 16% of young adults achieve the recommended amounts of physical activity. This lack of physical activity contributes the growing increases in obesity, diabetes, as well as premature CVD in the UAE. Whilst there are few studies examining the impact of physical activity on health specifically within a UAE population, there is a rapid need for of studies focused on generating quantitative data sets. This, and also genetic and epigenetic based studies, would greatly contribute towards an enhanced and holistic understanding of CVD in the UAE population.
LanguageEnglish
Title of host publicationHealthcare in the Arab world
Publication statusAccepted/In press - 2 Jul 2019

Fingerprint

Exercise
Health
Cardiovascular Diseases
Obesity
Population
Dyslipidemias
Vasoconstriction
Epigenomics
Blood Vessels
Insulin Resistance
Young Adult
Nitric Oxide
Chronic Disease
Hypertension
Therapeutics

Keywords

  • Physical Activity
  • Sedentary Behavior
  • Exercise
  • United Arab Emirates
  • Cardiovascular disease
  • Diabetes
  • Obesity

Cite this

Davison, G., & Dalibalta, S. (Accepted/In press). Exercise and Cardiovascular Health in the UAE. In Healthcare in the Arab world
Davison, Gareth ; Dalibalta, Sarah. / Exercise and Cardiovascular Health in the UAE. Healthcare in the Arab world. 2019.
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title = "Exercise and Cardiovascular Health in the UAE",
abstract = "Exercise and physical activity are fundamental in the prevention and treatment of chronic diseases such as cardiovascular disease (CVD). The underlying mechanisms through which exercise in particular can mediate its effects have been well studied and include, but is not limited to, changes in the vascular nitric oxide pathway, leading to a reduction in pathological vasoconstriction and enhanced endothelial function. The harmful effects of many risk factors for CVD such as hypertension, dyslipidaemia, insulin resistance and obesity, can be mitigated by regular exercise. The majority of the UAE adult population currently are sedentary, and perhaps even more noteworthy is that only 16{\%} of young adults achieve the recommended amounts of physical activity. This lack of physical activity contributes the growing increases in obesity, diabetes, as well as premature CVD in the UAE. Whilst there are few studies examining the impact of physical activity on health specifically within a UAE population, there is a rapid need for of studies focused on generating quantitative data sets. This, and also genetic and epigenetic based studies, would greatly contribute towards an enhanced and holistic understanding of CVD in the UAE population.",
keywords = "Physical Activity, Sedentary Behavior, Exercise, United Arab Emirates, Cardiovascular disease, Diabetes, Obesity",
author = "Gareth Davison and Sarah Dalibalta",
note = "World Health Organization WHO (2010). Global Recommendations on Physical Activity for Health. http://www.who.int/dietphysicalactivity/factsheet_recommendations/en/. Accessed 24 June 2018. World Health Organization WHO (2017a). Noncommunicable diseases. http://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases. Accessed 15 July 2018. NCD Risk Factor Collaboration (2017) Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. The Lancet, 390 (10113): 2627 – 2642. World Health Organization WHO (2014). Global Status Report on NCDs. http://www.who.int/nmh/publications/ncd-status-report-2014/en/. Accessed 21 July 2018. World Health Organization WHO (2017b). Cardiovascular diseases. http://www.who.int/cardiovascular_diseases/en/. Accessed 21 July 2018. World Health Federation WHF (2017). Different heart diseases. https://www.world-heart-federation.org/resources/different-heart-diseases/. Accessed 24 June 2018. McGill H, Herderick E, McMahan C, Zieske A, Malcolm G, Tracy RE, et al. (2002) Atherosclerosis in youth. Minerva Pediatr. 54(5):437-47. Mahmood S, Levy D, Vasan R, Wang T. (2014). The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective. The Lancet. 383(9921):999-1008. doi: 10.1016/S0140-6736(13)61752-3. Jousilahti P, Vartiainen E, Tuomilehto J, Puska P (1999). Sex, Age, Cardiovascular Risk Factors, and Coronary Heart Disease, A Prospective Follow-Up Study of 14 786 Middle-Aged Men and Women in Finland. Circulation, 99:1165-1172. Chow C, Islam S, Bautista L, Rumboldt Z, Yusufali A, Xie C, et al. (2011). Parental history and myocardial infarction risk across the world: the INTERHEART Study. J Am Coll Cardiol. 57(5): 619–627. doi: 10.1016/j.jacc.2010.07.054. Leigh J, Alvarez M, Rodriguez C. (2016) Ethnic Minorities and Coronary Heart Disease: an Update and Future Directions. Current atherosclerosis reports. 18(2):9. doi:10.1007/s11883-016-0559-4. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The Lancet. 364(9438): 937–952. doi: 10.1016/S0140-6736(04)17018-9 Centers for Disease Control and Prevention CDC US (2014). 2014 Surgeon General's Report: The Health Consequences of Smoking—50 Years of Progress. https://www.cdc.gov/tobacco/data_statistics/sgr/50th-anniversary/index.htm . Accessed: 22 July 2018. Mensah G, Wei G, Sorlie P, Fine L, Rosenberg Y, Kaufmann P et al. (2017) Decline in Cardiovascular Mortality: Possible Causes and Implications. Circulation research. 120(2):366-380. doi:10.1161/CIRCRESAHA.116.309115. Barnoya J and Glantz S. (2005) Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation. 111(20): 2684–2698. doi: 10.1161/CIRCULATIONAHA.104.492215 Elsayed Y, Dalibalta S, El Kouche M. (2017) Chemical characterization and safety assessment of dokha: An emerging alternative tobacco product. Sci Total Environ. 615: 9–14. doi: 10.1016/j.scitotenv.2017.09.255 O'Donnell C and Elosua R. (2008) Cardiovascular risk factors. Insights from Framingham Heart Study. Rev Esp Cardiol. 61(3): 299–310. Steptoe A and Kivim{\"a}ki M. (2013) Stress and Cardiovascular Disease: An Update on Current Knowledge. Annual Review of Public Health 34:1, 337-354. Sattelmair J, Pertman J, Ding E, Kohl H, Haskell W, Lee I-M. (2011) Dose-Response Between Physical Activity and Risk of Coronary Heart Disease: A Meta-Analysis. Circulation. 124(7):789-795. doi:10.1161/CIRCULATIONAHA.110.010710. Nocon M, Hiemann T, M{\"u}ller-Riemenschneider F, Thalau F, Roll S, Willich S. (2008) Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. Eur J Cardiovasc Prev Rehabil. 15(3): 239–246. doi: 10.1097/HJR.0b013e3282f55e09. Kemi O, Haram P, Loennechen J, Osnes J, Skomedal T, Wisl{\o}ff U et al. (2005) Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovasc Res. 67(1): 161–172. doi: 10.1016/j.cardiores.2005.03.010. Schuler G, Adams V, Goto Y. (2013) Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives. Eur Heart J. 2013 Jun; 34(24): 1790–1799. doi: 10.1093/eurheartj/eht111. Fisslthaler B, Dimmeler S, Hermann C, Busse R, Fleming I. (2000) Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress. Acta Physiol Scand. 168:81–88. Hambrecht R, Adams V, Erbs S, Linke A, Kr{\"a}nkel N, Shu Y, et al. (2003) Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation. 107(25): 3152–3158. doi: 10.1161/01.CIR.0000074229.93804.5C. Dinenno F, Tanaka H, Monahan K, Clevenger C, Eskurza I, DeSouza C, et al. (2001). Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. The Journal of Physiology. 534(Pt 1):287-295. doi:10.1111/j.1469-7793.2001.00287.x. Kannel W, D'Agostino R, Silbershatz H, Belanger A, Wilson P, Levy D. (1999) Profile for estimating risk of heart failure. Arch Intern Med. 159(11): 1197–1204. Kachur S, Chongthammakun V, Lavie C, Schutter A, Arena R, Milani R, et al. (2017) Impact of Cardiac Rehabilitation and Exercise Training Programs in Coronary Heart Disease. Prog Cardiovasc Dis. 60(1):103-114. doi: 10.1016/j.pcad.2017.07.002. Heran B, Chen J, Ebrahim S, Moxham T, Oldridge N, Rees K, et al. (2011). Exercise-based cardiac rehabilitation for coronary heart disease. The Cochrane Database of Systematic Reviews, (7), CD001800. http://doi.org/10.1002/14651858.CD001800.pub2. Taylor R, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. (2004) Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 116(10): 682–692. doi: 10.1016/j.amjmed.2004.01.009. Hambrecht R, Niebauer J, Marburger C, Grunze M, K{\"a}lberer B, Hauer K, et al. (1993) Various intensities of leisure time physical activity in patients with coronary artery disease: effects on cardiorespiratory fitness and progression of coronary atherosclerotic lesions. J Am Coll Cardiol. 22(2): 468–477. Pi{\~n}a I, Apstein C, Balady G, Belardinelli R, Chaitman B, Duscha B, et al. (2003) Exercise and heart failure: A statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. 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year = "2019",
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Davison, G & Dalibalta, S 2019, Exercise and Cardiovascular Health in the UAE. in Healthcare in the Arab world.

Exercise and Cardiovascular Health in the UAE. / Davison, Gareth; Dalibalta, Sarah.

Healthcare in the Arab world. 2019.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Exercise and Cardiovascular Health in the UAE

AU - Davison, Gareth

AU - Dalibalta, Sarah

N1 - World Health Organization WHO (2010). Global Recommendations on Physical Activity for Health. http://www.who.int/dietphysicalactivity/factsheet_recommendations/en/. Accessed 24 June 2018. World Health Organization WHO (2017a). Noncommunicable diseases. http://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases. Accessed 15 July 2018. NCD Risk Factor Collaboration (2017) Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. The Lancet, 390 (10113): 2627 – 2642. World Health Organization WHO (2014). Global Status Report on NCDs. http://www.who.int/nmh/publications/ncd-status-report-2014/en/. Accessed 21 July 2018. World Health Organization WHO (2017b). Cardiovascular diseases. http://www.who.int/cardiovascular_diseases/en/. Accessed 21 July 2018. World Health Federation WHF (2017). Different heart diseases. https://www.world-heart-federation.org/resources/different-heart-diseases/. Accessed 24 June 2018. McGill H, Herderick E, McMahan C, Zieske A, Malcolm G, Tracy RE, et al. (2002) Atherosclerosis in youth. Minerva Pediatr. 54(5):437-47. Mahmood S, Levy D, Vasan R, Wang T. (2014). The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective. The Lancet. 383(9921):999-1008. doi: 10.1016/S0140-6736(13)61752-3. Jousilahti P, Vartiainen E, Tuomilehto J, Puska P (1999). Sex, Age, Cardiovascular Risk Factors, and Coronary Heart Disease, A Prospective Follow-Up Study of 14 786 Middle-Aged Men and Women in Finland. Circulation, 99:1165-1172. Chow C, Islam S, Bautista L, Rumboldt Z, Yusufali A, Xie C, et al. (2011). Parental history and myocardial infarction risk across the world: the INTERHEART Study. J Am Coll Cardiol. 57(5): 619–627. doi: 10.1016/j.jacc.2010.07.054. Leigh J, Alvarez M, Rodriguez C. (2016) Ethnic Minorities and Coronary Heart Disease: an Update and Future Directions. Current atherosclerosis reports. 18(2):9. doi:10.1007/s11883-016-0559-4. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The Lancet. 364(9438): 937–952. doi: 10.1016/S0140-6736(04)17018-9 Centers for Disease Control and Prevention CDC US (2014). 2014 Surgeon General's Report: The Health Consequences of Smoking—50 Years of Progress. https://www.cdc.gov/tobacco/data_statistics/sgr/50th-anniversary/index.htm . Accessed: 22 July 2018. Mensah G, Wei G, Sorlie P, Fine L, Rosenberg Y, Kaufmann P et al. (2017) Decline in Cardiovascular Mortality: Possible Causes and Implications. Circulation research. 120(2):366-380. doi:10.1161/CIRCRESAHA.116.309115. Barnoya J and Glantz S. (2005) Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation. 111(20): 2684–2698. doi: 10.1161/CIRCULATIONAHA.104.492215 Elsayed Y, Dalibalta S, El Kouche M. (2017) Chemical characterization and safety assessment of dokha: An emerging alternative tobacco product. Sci Total Environ. 615: 9–14. doi: 10.1016/j.scitotenv.2017.09.255 O'Donnell C and Elosua R. (2008) Cardiovascular risk factors. Insights from Framingham Heart Study. Rev Esp Cardiol. 61(3): 299–310. Steptoe A and Kivimäki M. (2013) Stress and Cardiovascular Disease: An Update on Current Knowledge. Annual Review of Public Health 34:1, 337-354. Sattelmair J, Pertman J, Ding E, Kohl H, Haskell W, Lee I-M. (2011) Dose-Response Between Physical Activity and Risk of Coronary Heart Disease: A Meta-Analysis. Circulation. 124(7):789-795. doi:10.1161/CIRCULATIONAHA.110.010710. Nocon M, Hiemann T, Müller-Riemenschneider F, Thalau F, Roll S, Willich S. (2008) Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. Eur J Cardiovasc Prev Rehabil. 15(3): 239–246. doi: 10.1097/HJR.0b013e3282f55e09. Kemi O, Haram P, Loennechen J, Osnes J, Skomedal T, Wisløff U et al. (2005) Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovasc Res. 67(1): 161–172. doi: 10.1016/j.cardiores.2005.03.010. Schuler G, Adams V, Goto Y. (2013) Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives. Eur Heart J. 2013 Jun; 34(24): 1790–1799. doi: 10.1093/eurheartj/eht111. Fisslthaler B, Dimmeler S, Hermann C, Busse R, Fleming I. (2000) Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress. Acta Physiol Scand. 168:81–88. Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, Shu Y, et al. (2003) Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation. 107(25): 3152–3158. doi: 10.1161/01.CIR.0000074229.93804.5C. Dinenno F, Tanaka H, Monahan K, Clevenger C, Eskurza I, DeSouza C, et al. (2001). Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. The Journal of Physiology. 534(Pt 1):287-295. doi:10.1111/j.1469-7793.2001.00287.x. Kannel W, D'Agostino R, Silbershatz H, Belanger A, Wilson P, Levy D. (1999) Profile for estimating risk of heart failure. Arch Intern Med. 159(11): 1197–1204. Kachur S, Chongthammakun V, Lavie C, Schutter A, Arena R, Milani R, et al. (2017) Impact of Cardiac Rehabilitation and Exercise Training Programs in Coronary Heart Disease. Prog Cardiovasc Dis. 60(1):103-114. doi: 10.1016/j.pcad.2017.07.002. Heran B, Chen J, Ebrahim S, Moxham T, Oldridge N, Rees K, et al. (2011). Exercise-based cardiac rehabilitation for coronary heart disease. The Cochrane Database of Systematic Reviews, (7), CD001800. http://doi.org/10.1002/14651858.CD001800.pub2. Taylor R, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. (2004) Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 116(10): 682–692. doi: 10.1016/j.amjmed.2004.01.009. Hambrecht R, Niebauer J, Marburger C, Grunze M, Kälberer B, Hauer K, et al. (1993) Various intensities of leisure time physical activity in patients with coronary artery disease: effects on cardiorespiratory fitness and progression of coronary atherosclerotic lesions. J Am Coll Cardiol. 22(2): 468–477. Piña I, Apstein C, Balady G, Belardinelli R, Chaitman B, Duscha B, et al. (2003) Exercise and heart failure: A statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. Circulation. 107(8): 1210–1225. Wisløff U, Støylen A, Loennechen J, Bruvold M, Rognmo O, Haram P, et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 115(24): 3086–3094. doi: 10.1161/CIRCULATIONAHA.106.675041. O'Connor G, Buring J, Yusuf S, Goldhaber S, Olmstead E, Paffenbarger R, et al. (1989) An overview of randomized trials of rehabilitation with exercise after myocardial infarction. Circulation. 80(2): 234–244. Lawler P, Filion K, Eisenberg M. (2011) Efficacy of exercise-based cardiac rehabilitation post-myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. Am Heart J. 162(4): 571–584.e2. doi: 10.1016/j.ahj.2011.07.017. Pressler A, Christle J, Lechner B, Grabs V, Haller B, Hettich I, et al. (2016) Exercise training improves exercise capacity and quality of life after transcatheter aortic valve implantation: A randomized pilot trial. 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PY - 2019/7/2

Y1 - 2019/7/2

N2 - Exercise and physical activity are fundamental in the prevention and treatment of chronic diseases such as cardiovascular disease (CVD). The underlying mechanisms through which exercise in particular can mediate its effects have been well studied and include, but is not limited to, changes in the vascular nitric oxide pathway, leading to a reduction in pathological vasoconstriction and enhanced endothelial function. The harmful effects of many risk factors for CVD such as hypertension, dyslipidaemia, insulin resistance and obesity, can be mitigated by regular exercise. The majority of the UAE adult population currently are sedentary, and perhaps even more noteworthy is that only 16% of young adults achieve the recommended amounts of physical activity. This lack of physical activity contributes the growing increases in obesity, diabetes, as well as premature CVD in the UAE. Whilst there are few studies examining the impact of physical activity on health specifically within a UAE population, there is a rapid need for of studies focused on generating quantitative data sets. This, and also genetic and epigenetic based studies, would greatly contribute towards an enhanced and holistic understanding of CVD in the UAE population.

AB - Exercise and physical activity are fundamental in the prevention and treatment of chronic diseases such as cardiovascular disease (CVD). The underlying mechanisms through which exercise in particular can mediate its effects have been well studied and include, but is not limited to, changes in the vascular nitric oxide pathway, leading to a reduction in pathological vasoconstriction and enhanced endothelial function. The harmful effects of many risk factors for CVD such as hypertension, dyslipidaemia, insulin resistance and obesity, can be mitigated by regular exercise. The majority of the UAE adult population currently are sedentary, and perhaps even more noteworthy is that only 16% of young adults achieve the recommended amounts of physical activity. This lack of physical activity contributes the growing increases in obesity, diabetes, as well as premature CVD in the UAE. Whilst there are few studies examining the impact of physical activity on health specifically within a UAE population, there is a rapid need for of studies focused on generating quantitative data sets. This, and also genetic and epigenetic based studies, would greatly contribute towards an enhanced and holistic understanding of CVD in the UAE population.

KW - Physical Activity

KW - Sedentary Behavior

KW - Exercise

KW - United Arab Emirates

KW - Cardiovascular disease

KW - Diabetes

KW - Obesity

M3 - Chapter

BT - Healthcare in the Arab world

ER -

Davison G, Dalibalta S. Exercise and Cardiovascular Health in the UAE. In Healthcare in the Arab world. 2019